SU-E-T-388: Dosimetric Study of a New-Generation Iodine-125 Source in Polymer: Dosimetric Impact of Fluorescence X-Rays

2011 ◽  
Vol 38 (6Part16) ◽  
pp. 3577-3577
Author(s):  
F Abboud ◽  
M Hollows ◽  
P Scalliet ◽  
S Vynckier
2009 ◽  
Vol 92 ◽  
pp. S77
Author(s):  
S. Vynckier ◽  
F. Abboud ◽  
M. Hollows ◽  
P. Scalliet

2004 ◽  
Vol 194 ◽  
pp. 75-76
Author(s):  
N. A. Webb ◽  
B. Gendre ◽  
D. Barret

AbstractGlobular clusters (GCs) harbour a large number of close binaries which are hard to identify optically due to high stellar densities. Observing these GCs in X-rays, in which the compact binaries are bright, diminishes the over-crowding problem. Using the new generation of X-ray observatories, it is possible to identify populations of neutron star low mass X-ray binaries, cataclysmic variables and millisecond pulsars as well as other types of binaries. We present the spectra of a variety of binaries that we have identified in four GCs observed by XMM-Newton. We show that through population studies we can begin to understand the formation of individual classes of binaries in GCs and hence start to unfold the complex evolutionary paths of these systems.


2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 232-232
Author(s):  
Konstantin Kovtun ◽  
Luciant D. Wolfsberger ◽  
Thomas Niedermayr ◽  
Emily Neubauer ◽  
Yonina R. Murciano-Goroff ◽  
...  

232 Background: Prostate brachytherapy is often avoided in men with small prostate volumes (PV) due to concerns about suboptimal dosimetry. We characterized prostate swelling and dosimetry in patients with small PVs compared with large PVs. Methods: We studied twenty-five patients with PV <25 cc (range 15.1-24.8) and sixty-five patients with PV >=25 cc (range 25.0-66.2) who underwent brachytherapy. Gland size was based on the contoured volume on a 3D transrectal ultrasound before the procedure. Ultrasound-guided brachytherapy was performed under intra-operative planning with loose Iodine-125 seeds to a prescription dose of 145 Gy. Patients underwent CT and MRI scans on post-implant Days 1 and 30 for dosimetric study. MRI was used to contour the prostate and then fused with the CT for dosimetry. Results: Small PVs had greater Day 1 post-implant swelling than patients with large PVs (32.5% increase in volume vs. 23.7%, p=0.04) but Day 30 swelling was minimal and not significantly different (4.4% increase in volume vs. 1.6%, p=0.44) for small and large PVs respectively. Small PVs had greater seed and needle density at implant (p<0.001). Small PV patients had larger Day 1 hot spots in the prostate at (V150 = 59.6% vs. 53.0, p=0 .022) which resolved by Day 30 (V150 = 70.9% vs. 67.1, p=0.20). Rectal and urethral doses were nearly identical by Day 30 (Small PV RV100 = 0.32 cc, Large PV RV100 = 0.33 cc, p=0.99; small PV UV150 = 0.20, large PV UV150 = 0.20, p=0.91). Day 1 swelling created cold areas (rate D90>140 Gy = 88.0% and 90.6% for the small and large PV groups respectively, p=0.71), but day 30 dosimetry was excellent (rate D90>140 Gy = 100% for both groups). Conclusions: While smaller prostates have more immediate post-operative swelling, good Day 30 dosimetry can be achieved in small prostates, which makes them excellent candidates for treatment with I-125 seeds (t½ = 60 days). Due to the increased short-term swelling, small prostates may be suboptimal candidates for implants done with shorter half-life sources such as cesium-131 (t½ = 9.7 days), where the majority of the dose may be delivered to an edematous gland.


Photonics ◽  
2021 ◽  
Vol 8 (12) ◽  
pp. 579
Author(s):  
Marek Raclavský ◽  
Krishna P. Khakurel ◽  
Uddhab Chaulagain ◽  
Marcel Lamač ◽  
Jaroslav Nejdl

A new generation of small-scale ultrafast X-ray sources is rapidly emerging. Laser-driven betatron radiation represents an important class of such ultrafast X-ray sources. With the sources driving towards maturity, many important applications in material and biological sciences are expected to be carried out. While the last decade mainly focused on the optimization of the source properties, the development of such sources into user-oriented beamlines in order to explore the potential applications has recently taken off and is expected to grow rapidly. An important aspect in the realization of such beamlines will be the implementation of proper X-ray optics. Here, we present the design of a multi-lane X-ray mirror as a versatile focusing device covering a wide spectral range of betatron X-rays. The expected photon flux in the focal plane of such optics was also estimated through geometrical simulations.


Author(s):  
J. P. Marangos

In this theme issue, leading researchers discuss recent work on the measurement of ultrafast electronic and structural dynamics in matter using a new generation of short duration X-ray photon sources. These photon sources, based upon high harmonic generation from lasers and X-ray free-electron lasers, look set to have a high impact on ultrafast science. This article is part of the theme issue ‘Measurement of ultrafast electronic and structural dynamics with X-rays’.


2015 ◽  
Vol 42 (6Part11) ◽  
pp. 3333-3333
Author(s):  
X Liu ◽  
J Rahimian ◽  
B Goy ◽  
H Cosmatos ◽  
Y Qian
Keyword(s):  

2010 ◽  
Vol 37 (5) ◽  
pp. 2054-2062 ◽  
Author(s):  
F. Abboud ◽  
M. Hollows ◽  
P. Scalliet ◽  
S. Vynckier
Keyword(s):  
X Rays ◽  

2022 ◽  
Author(s):  
Lu Lu ◽  
Mingzi Sun ◽  
Tong Wu ◽  
Qiuyang Lu ◽  
Baian Chen ◽  
...  

With super strong penetrability, high-energy X-rays can be applied to probe the inner structure of target objects under nondestructive situations. Scintillation materials can down-convert X-rays into visible light, enabling the...


Diagnostics ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 47
Author(s):  
Stan Benjamens ◽  
Cyril Moers ◽  
Riemer H.J.A. Slart ◽  
Robert A. Pol

The first steps for modern organ transplantation were taken by Emerich Ullmann (Vienne, Austria) in 1902, with a dog-to-dog kidney transplant, and ultimate success was achieved by Joseph Murray in 1954, with the Boston twin brothers. In the same time period, the ground-breaking work of Wilhelm C. Röntgen (1895) and Maria Sklodowska-Curie (1903), on X-rays and radioactivity, enabled the introduction of diagnostic imaging. In the years thereafter, kidney transplantation and diagnostic imaging followed a synergistic path for their development, with key discoveries in transplant rejection pathways, immunosuppressive therapies, and the integration of diagnostic imaging in transplant programs. The first image of a transplanted kidney, a urogram with intravenous contrast, was shown to the public in 1956, and the first recommendations for transplantation diagnostic imaging were published in 1958. Transplant surgeons were eager to use innovative diagnostic modalities, with renal scintigraphy in the 1960s, as well as ultrasound and computed tomography in the 1970s. The use of innovative diagnostic modalities has had a great impact on the reduction of post-operative complications in kidney transplantation, making it one of the key factors for successful transplantation. For the new generation of transplant surgeons, the historical alignment between transplant surgery and diagnostic imaging can be a motivator for future innovations.


2018 ◽  
Vol 18 (3) ◽  
pp. 77-84
Author(s):  
E V Murzina ◽  
G A Sofronov ◽  
A S Simbirtsev ◽  
N V Aksenova ◽  
O M Veselova ◽  
...  

Research objective. To evaluate the radioprotective effectiveness of recombinant flagellin when used alone or in combination with interleukin-1 beta for prophylactic or therapeutic effect on animals. Materials and methods. The effect of hybrid flagellin FliC Salmonella typhimurium and human interleukin-1β (Institute of Highly Pure Biopreparations, Saint Petersburg, Russia) on the 30-day survival of male mice exposed to lethal doses of X-ray radiation was studied. Survival of irradiated animals was analyzed by Kaplan-Meier method. Results. The preventive use of flagellin had a protective effect on the 30-day survival of mice irradiated with lethal doses of X-rays. Compared with the irradiated control, the administration of flagellin (1 mg/kg or 2 mg/kg) prior to X-ray exposure (7.5 Gy, 8.0 Gy or 8.5 Gy) increased the animal survival rate to 67-87%. Complex preventive administration of flagellin (1 mg/kg) and interleukin-1 beta (50 μg/kg) provided a 100% survival rate of the irradiated mice. Separate use of drugs was also effective; 92.8% of mice survived when flagellin was administered prior to irradiation and interleukin after. Conclusion. Recombinant flagellin is a promising candidate product for designing new generation of domestic radiation countermeasures, including combinations with interleukin-1 beta.


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