SU-E-T-352: Comparison of Dose Distributions Between Two Arrangements of a Range Compensator and of An Aperture Collimator in a Passive Scattering Method for Proton Therapy

2011 ◽  
Vol 38 (6Part16) ◽  
pp. 3568-3568
Author(s):  
K Hotta ◽  
R Kohno ◽  
Y Takada ◽  
Y Hara ◽  
R Tansho
Keyword(s):  
Proton Therapy ◽  
Scattering Method ◽  
Dose Distributions ◽  
Passive Scattering

Physics of Proton Therapy Treatment Planning

2019 ◽  
pp. 23-32
Author(s):  
В. Климанов ◽  
V. Klimanov ◽  
А. Самойлов ◽  
A. Samoylov ◽  
А. Гаджинов ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proton Therapy ◽  
Physical Planning ◽  
High Dose ◽  
Scattering Method ◽  
Proton Radiation ◽  
Dose Distributions ◽  
Scanning Method ◽  
Proton Radiation Therapy ◽  
Path Lengths

The most important stage of radiation therapy of oncological diseases is the planning of radiation treatment. In this work, this complex process in relation to proton therapy is proposed to be divided into medical and physical planning. In conventional therapy with photons and electrons, the latter is usually called dosimetric planning, however, when applied to proton radiation therapy, this stage involves a significantly wider range of tasks related to the modification and scanning of the proton beam, spreading and compensation of ranges, taking into account when planning for uncertainties and finiteness of proton ranges, a decrease in the contribution to the dose of secondary neutrons, the creation of error-tolerant optimization algorithms for dosimetric plans, and, finally, a precision calculation of dose distributions. The paper discusses the main stages and problems of physical planning of proton radiation therapy. Particular attention is paid to the formation of an extended high-dose region (extended Bragg peak) using the beam scattering method and scanning method, and to the algorithms for calculating the dose distributions created by protons in the scattering and beam scanning systems. The most detailed consideration is given to different versions of the proton pencil beam method, which allows to increase the dose calculation accuracy and take into account the transverse scattering and fluctuations in proton energy losses, especially at the end of the path (halo effect), analytical and numerical methods. Scanning are divided into three main technologies: homogeneous scanning, single field uniform dose (SFUD), multi-field uniform dose (MFUD), often called intensity modulated proton therapy (IMPT). Actual accounting problems are considered when planning the irradiation of the movement of organs, and uncertainties in determining path lengths and optimization of irradiation plans. In particular features, problems and modern approaches to the optimization of dosimetry plans of proton radiation therapy are discussed. It is noted that one of the most promising practical solutions for the uncertainty management in determining the path lengths of protons in optimization is to include possible errors in the objective function of the optimization algorithm. This technique ensures that an optimized irradiation plan will more reliably protect normal tissues and critical organs adjacent to the irradiation target from overexposure.

Depth Dose Measurement using a Scintillating Fiber Optic Dosimeter for Proton Therapy Beam of the Passive-Scattering Mode Having Range Modulator Wheel

2018 ◽  
Vol 72 (9) ◽  
pp. 1025-1032 ◽  
Author(s):  
Ui-Jung Hwang ◽  
Dongho Shin ◽  
Se Byeong Lee ◽  
Young Kyung Lim ◽  
Jong Hwi Jeong ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Fiber Optic ◽  
Dose Measurement ◽  
Depth Dose ◽  
Scintillating Fiber ◽  
Passive Scattering

scholarly journals Proton therapy for non-squamous cell carcinoma of the head and neck: planning comparison and toxicity

2019 ◽  
Vol 60 (5) ◽  
pp. 612-621 ◽  
Author(s):  
Hiromitsu Iwata ◽  
Toshiyuki Toshito ◽  
Kensuke Hayashi ◽  
Maho Yamada ◽  
Chihiro Omachi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Proton Therapy ◽  
Patient Specific ◽  
Dose Distributions

Abstract To investigate optimal treatment planning using proton beams for non-squamous cell carcinoma of the head and neck (NSCHN), the dose distributions of plans involving pencil beam scanning (PBS) with or without a patient-specific aperture system (PSAS), passive-scattering proton therapy (PSPT) and X-ray intensity-modulated radiotherapy (IMRT) were compared. As clinical results, toxicities of PBS with PSAS, including changes in quality of life, were reported. Between April 2014 and August 2016, a total of 30 patients were treated using PBS with PSAS. In 20 patients selected at random, the dose distributions of PBS with or without the PSAS, PSPT and IMRT plans were compared. Neutron exposure by proton therapy was calculated using a Monte Carlo simulation. Toxicities were scored according to CTCAE ver. 4.0. Patients completed EORTC quality of life survey forms (QLQ-C30 and QLQ-HN35) before and 0–12 months after proton therapy. The 95% conformity number of PBS with the PSAS plan was the best, and significant differences were detected among the four plans (P < 0.05, Bonferroni tests). Neutron generation by PSAS was ~1.1-fold higher, but was within an acceptable level. No grade 3 or higher acute dermatitis was observed. Pain, appetite loss and increased weight loss were more likely at the end of treatment, but recovered by the 3 month follow-up and returned to the pretreatment level at the 12 month follow-up. PBS with PSAS reduced the penumbra and improved dose conformity in the planning target volume. PBS with PSAS was tolerated well for NSCHN.

scholarly journals Inter-comparison of Dose Distributions Calculated by FLUKA, GEANT4, MCNP, and PHITS for Proton Therapy

2017 ◽  
Vol 153 ◽  
pp. 04011 ◽  
Author(s):  
Zi-Yi Yang ◽  
Pi-En Tsai ◽  
Shao-Chun Lee ◽  
Yen-Chiang Liu ◽  
Chin-Cheng Chen ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Dose Distributions
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