SU-E-I-180: Simulation of Arterial First Pass and Recirculation Input Functions Using a Series of Related Gamma Variate Function

2011 ◽  
Vol 38 (6Part6) ◽  
pp. 3438-3438
Author(s):  
S Yee ◽  
K Ogden
Keyword(s):  
Gamma Variate ◽  
First Pass

Embedding Procedure for Water Swollen Samples

1970 ◽  
Vol 28 ◽  
pp. 504-505
Author(s):  
Ann M. Thomas ◽  
Virginia Shemeley
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Ion Exchange ◽  
Structural Changes ◽  
Cross Linking ◽  
Ion Exchange Resins ◽  
Transmission Electron ◽  
First Pass ◽  
Exchange Resins

Those samples which swell rapidly when exposed to water are, at best, difficult to section for transmission electron microscopy. Some materials literally burst out of the embedding block with the first pass by the knife, and even the most rapid cutting cycle produces sections of limited value. Many ion exchange resins swell in water; some undergo irreversible structural changes when dried. We developed our embedding procedure to handle this type of sample, but it should be applicable to many materials that present similar sectioning difficulties.The purpose of our embedding procedure is to build up a cross-linking network throughout the sample, while it is in a water swollen state. Our procedure was suggested to us by the work of Rosenberg, where he mentioned the formation of a tridimensional structure by the polymerization of the GMA biproduct, triglycol dimethacrylate.

Evidence for Early closure Attachment on First pass Reading Times in French

1997 ◽  
Vol 50 (2) ◽  
pp. 421-438 ◽  
Author(s):  
Daniel Zagar ◽  
Joel Pynte ◽  
Sylvie Rativeau
Keyword(s):  
First Pass ◽  
Early Closure

Therapie mit Opioiden bei Patienten mit Leberzirrhose

2020 ◽  
Vol 77 (1) ◽  
pp. 14-19
Author(s):  
Stephan Krähenbühl
Keyword(s):  
First Pass

Zusammenfassung. Für die Dosisangleichung bei Patienten mit Leberzirrhose gibt es keinen verlässlichen endogenen Parameter, der die metabolische Aktivität und das Ausmass der portacavalen Shunts repräsentiert. Die Angleichung muss deshalb unter Beachtung der pharmakokinetischen Eigenschaften der verabreichten Arzneistoffe erfolgen. Bei Arzneistoffen mit einem starken Abbau während der ersten Passage durch die Leber (first-pass Effekt) muss nach oraler Verabreichung mit einer Zunahme der Bioverfügbarkeit und verminderter Clearance gerechnet werden. Nach topischer, buccaler oder parenteraler Applikation spielt nur der Effekt auf die Clearance eine Rolle. Für Arzneistoffe mit einer hohen Bioverfügbarkeit (> 70 %) ist ebenfalls nur die hepatische Clearance entscheidend. In der Folge werden die in der Schweiz gebräuchlichen Opioide bezüglich pharmakokinetischer Eigenschaften und Konsequenzen bezüglich Dosisangleichung bei Patienten mit Leberzirrhose besprochen. Buprenorphin, Fentanyl, Hydromorphon, Morphin, Naloxon und Tapentadol sind Arzneistoffe mit einem hohen first-pass Effekt, währenddem Methadon, Oxycodon und Tramadol eine Bioverfügbarkeit von > 70 % aufweisen.

Einfluss der Gadofosveset-Injektionsgeschwindigkeit auf die Bildqualität der First-Pass MRA

2009 ◽  
Vol 181 (S 01) ◽  
Author(s):  
HJ Michaely ◽  
UI Attenberger ◽  
C Fink ◽  
O Dietrich ◽  
SO Schoenberg
Keyword(s):  
First Pass

Demonstration and Quantitation of Pharmacological Inhibition of Pulmonary Uptake of N-lsopropyl-123l-p-lodoamphetamine by Propranolol

1989 ◽  
Vol 28 (03) ◽  
pp. 100-104 ◽  
Author(s):  
S. F. Akber
Keyword(s):  
Binding Sites ◽  
Bolus Injection ◽  
Cell Function ◽  
Lung Pathology ◽  
Lung Uptake ◽  
Pharmacological Inhibition ◽  
Sensitive Index ◽  
Pulmonary Uptake ◽  
First Pass

The first-pass pulmonary extraction values of N-lsopropyl-123l-p-lodoamphetamine (123I-IMP) in pretreated dogs decreases from 90 to 62% as the amount of propranolol increases from 0 to 20 mg. The first-pass pulmonary extraction values of 123I-IMP in dogs with a simultaneous bolus injection of propranolol decreases from 90 to 62% as the amount of propranolol increases from 0 to 10 mg. The pulmonary extraction of 123I-IMP with a simultaneous bolus injection of ketamine and 123I-IMP decreases from 90 to 64% as the ketamine dose increases from 0 to 100 mg. These results suggest that the pulmonary uptake of 123I-IMP may be at least partially mediated by receptors. They also indicate that endothelial metabolic cell function may be a useful index of early lung pathology. Furthermore, studies of the degree of lung uptake may be a sensitive index of pathologic states in which alterations of amine binding sites have occurred.

Identification of a Cranberry Juice Product Capable of Inhibiting Enteric CYP3A-Mediated First-Pass Metabolism in Humans

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
N Ngo ◽  
Z Yan ◽  
TN Graf ◽  
DR Carrizosa ◽  
EC Dees ◽  
...  
Keyword(s):  
Cranberry Juice ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism

Enhanced Artificial Intelligent Method for Representing the Photonic Crystal Fiber Profile Index

2018 ◽  
Vol 1 (1) ◽  
pp. 2-19
Author(s):  
Mahmood Sh. Majeed ◽  
Raid W. Daoud
Keyword(s):  
Genetic Algorithms ◽  
Photonic Crystal ◽  
Photonic Crystal Fiber ◽  
New Method ◽  
Proper Solution ◽  
Artificial Intelligent ◽  
Crystal Fiber ◽  
Fitness Value ◽  
First Pass ◽  
Crossover And Mutation

A new method proposed in this paper to compute the fitness in Genetic Algorithms (GAs). In this new method the number of regions, which assigned for the population, divides the time. The fitness computation here differ from the previous methods, by compute it for each portion of the population as first pass, then the second pass begin to compute the fitness for population that lye in the portion which have bigger fitness value. The crossover and mutation and other GAs operator will do its work only for biggest fitness portion of the population. In this method, we can get a suitable and accurate group of proper solution for indexed profile of the photonic crystal fiber (PCF).

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