Radiotherapy is one of the main cancer treatments available today, together with chemotherapy and surgery. Radiotherapy treatments have to be planned for each patient in an individualized manner. The knowledge acquired from one single treatment can be used to improve the treatment planning and outcome of several other patients. In the last years, attention has been drawn to the added value of using data analysis for radiotherapy treatment planning, prediction of treatment outcomes, survival analysis and quality assurance. In this article, existing literature is reviewed.