Sci-Fri AM: Imaging - 06: Hyperpolarized 13 C Magnetic Resonance Imaging and Dynamic Spectroscopy for Detection of Radiation-Induced Lung Injury

2010 ◽  
Vol 37 (7Part3) ◽  
pp. 3903-3903
Author(s):  
K Thind ◽  
AV Ouriadov ◽  
L Friesen-Waldner ◽  
M Fox ◽  
E Wong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lung Injury ◽  
Resonance Imaging ◽  
Radiation Induced

Detection of longitudinal lung structural and functional changes after diagnosis of radiation-induced lung injury using hyperpolarized He3 magnetic resonance imaging

2009 ◽  
Vol 37 (1) ◽  
pp. 22-31 ◽  
Author(s):  
Lindsay Mathew ◽  
Stewart Gaede ◽  
Andrew Wheatley ◽  
Roya Etemad-Rezai ◽  
George B. Rodrigues ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lung Injury ◽  
Resonance Imaging ◽  
Functional Changes ◽  
Radiation Induced

Proton and hyperpolarized helium magnetic resonance imaging of radiation-induced lung injury in rats

2004 ◽  
Vol 58 (5) ◽  
pp. 1562-1569 ◽  
Author(s):  
Erika R Ward ◽  
Laurence W Hedlund ◽  
William C Kurylo ◽  
Charles T Wheeler ◽  
Gary P Cofer ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lung Injury ◽  
Resonance Imaging ◽  
Hyperpolarized Helium ◽  
Radiation Induced

scholarly journals Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury

2016 ◽  
Vol 311 (2) ◽  
pp. L208-L218 ◽  
Author(s):  
Dean O. Kuethe ◽  
Piotr T. Filipczak ◽  
Jeremy M. Hix ◽  
Andrew P. Gigliotti ◽  
Raúl San José Estépar ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lung Injury ◽  
Real Time ◽  
Critical Role ◽  
Lung Mechanics ◽  
Therapeutic Effects ◽  
Resonance Imaging ◽  
Ventilator Induced Lung Injury

Animal models play a critical role in the study of acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI). One limitation has been the lack of a suitable method for serial assessment of acute lung injury (ALI) in vivo. In this study, we demonstrate the sensitivity of magnetic resonance imaging (MRI) to assess ALI in real time in rat models of VILI. Sprague-Dawley rats were untreated or treated with intratracheal lipopolysaccharide or PBS. After 48 h, animals were mechanically ventilated for up to 15 h to induce VILI. Free induction decay (FID)-projection images were made hourly. Image data were collected continuously for 30 min and divided into 13 phases of the ventilatory cycle to make cinematic images. Interleaved measurements of respiratory mechanics were performed using a flexiVent ventilator. The degree of lung infiltration was quantified in serial images throughout the progression or resolution of VILI. MRI detected VILI significantly earlier (3.8 ± 1.6 h) than it was detected by altered lung mechanics (9.5 ± 3.9 h, P = 0.0156). Animals with VILI had a significant increase in the Index of Infiltration ( P = 0.0027), and early regional lung infiltrates detected by MRI correlated with edema and inflammatory lung injury on histopathology. We were also able to visualize and quantify regression of VILI in real time upon institution of protective mechanical ventilation. Magnetic resonance lung imaging can be utilized to investigate mechanisms underlying the development and propagation of ALI, and to test the therapeutic effects of new treatments and ventilator strategies on the resolution of ALI.

Multiple Spinal Cavernous Malformations with Atypical Phenotype after Prior Irradiation: Case Report

Neurosurgery ◽  
2004 ◽  
Vol 55 (6) ◽  
pp. E1435-E1439 ◽  
Author(s):  
Pascal Jabbour ◽  
Judith Gault ◽  
Steven E. Murk ◽  
Issam A. Awad
Keyword(s):  
Magnetic Resonance Imaging ◽  
Case Report ◽  
Magnetic Resonance ◽  
Wilms Tumor ◽  
Incidental Finding ◽  
Resonance Imaging ◽  
Cavernous Malformations ◽  
Drop Metastasis ◽  
History Of ◽  
Radiation Induced

Abstract OBJECTIVE AND IMPORTANCE: This is the first reported case of histologically proven multiple spinal cavernous malformations (CMs) associated with previous irradiation. There are only two cases reported in the literature of solitary spinal CM after irradiation. In addition, the lesions in our patient had an atypical magnetic resonance imaging appearance mimicking intraspinal drop metastasis. CLINICAL PRESENTATION: A 33-year-old man had an incidental finding of multiple enhancing intraspinal lesions as revealed by magnetic resonance imaging during staging tests for hepatocellular carcinoma. He had a history of Wilms' tumor at a young age with irradiation to the abdomen and pelvis. His family history included a paternal cousin with multiple cerebral CMs. The diagnosis of spinal drop metastasis was made, and further intervention was undertaken for confirmation. INTERVENTION: The patient underwent a lumbar laminectomy with durotomy and excision of two of the lesions. Macroscopic analysis revealed mulberry-like appearance with nerve root involvement, and pathological analysis confirmed the diagnosis of CM. Genetic testing of the patient and his affected cousin was negative for the CCM1 gene. CONCLUSION: The occurrence of multiple spinal lesions in the context of known neoplasia indicates a diagnosis of metastasis. Spinal CMs were not suspected preoperatively because of the atypical appearance revealed by magnetic resonance imaging scans, with uniform contrast enhancement and absence of hemosiderin rim. This case report is discussed relative to previous literature regarding radiation-induced CMs and other known causes of the disease.

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