SU-GG-T-229: Intensity Modulated Arc Therapy for Pediatric Brain Tumors

2010 ◽  
Vol 37 (6Part19) ◽  
pp. 3237-3238
Author(s):  
J Gray ◽  
C Beltran
Keyword(s):  
Brain Tumors ◽  
Pediatric Brain Tumors ◽  
Intensity Modulated ◽  
Arc Therapy ◽  
Pediatric Brain

Modeling of intensity-modulated focused ultrasound in pediatric brain tumors using acoustic holograms

2021 ◽  
Author(s):  
Sergio Jimenez-Gambin ◽  
Antonios N. Pouliopoulos ◽  
Zachary K. Englander ◽  
Noe Jimenez ◽  
Francisco Camarena ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Focused Ultrasound ◽  
Pediatric Brain Tumors ◽  
Intensity Modulated ◽  
Pediatric Brain

scholarly journals Modern Radiotherapy for Pediatric Brain Tumors

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1533
Author(s):  
Nicholas J. DeNunzio ◽  
Torunn I. Yock
Keyword(s):  
At Risk ◽  
Brain Tumors ◽  
Late Effects ◽  
Planning Process ◽  
Pediatric Brain Tumors ◽  
Target Volume ◽  
Radiation Beam ◽  
Term Survival ◽  
Intensity Modulated ◽  
Pediatric Brain

Cancer is a leading cause of death in children with tumors of the central nervous system, the most commonly encountered solid malignancies in this population. Radiotherapy (RT) is an integral part of managing brain tumors, with excellent long-term survival overall. The tumor histology will dictate the volume of tissue requiring treatment and the dose. However, radiation in developing children can yield functional deficits and/or cosmetic defects and carries a risk of second tumors. In particular, children receiving RT are at risk for neurocognitive effects, neuroendocrine dysfunction, hearing loss, vascular anomalies and events, and psychosocial dysfunction. The risk of these late effects is directly correlated with the volume of tissue irradiated and dose delivered and is inversely correlated with age. To limit the risk of developing these late effects, improved conformity of radiation to the target volume has come from adopting a volumetric planning process. Radiation beam characteristics have also evolved to achieve this end, as exemplified through development of intensity modulated photons and the use of protons. Understanding dose limits of critical at-risk structures for different RT modalities is evolving. In this review, we discuss the physical basis of the most common RT modalities used to treat pediatric brain tumors (intensity modulated radiation therapy and proton therapy), the RT planning process, survival outcomes for several common pediatric malignant brain tumor histologies, RT-associated toxicities, and steps taken to mitigate the risk of acute and late effects from treatment.

scholarly journals A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yiqun Zhang ◽  
Fengju Chen ◽  
Lawrence A. Donehower ◽  
Michael E. Scheurer ◽  
Chad J. Creighton
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Tyrosine Kinases ◽  
Pediatric Brain Tumor ◽  
Pediatric Brain Tumors ◽  
Altered Expression ◽  
Critical Pathways ◽  
Cis Regulation ◽  
Or Gene ◽  
Pediatric Brain

AbstractThe global impact of somatic structural variants (SSVs) on gene expression in pediatric brain tumors has not been thoroughly characterised. Here, using whole-genome and RNA sequencing from 854 tumors of more than 30 different types from the Children’s Brain Tumor Tissue Consortium, we report the altered expression of hundreds of genes in association with the presence of nearby SSV breakpoints. SSV-mediated expression changes involve gene fusions, altered cis-regulation, or gene disruption. SSVs considerably extend the numbers of patients with tumors somatically altered for critical pathways, including receptor tyrosine kinases (KRAS, MET, EGFR, NF1), Rb pathway (CDK4), TERT, MYC family (MYC, MYCN, MYB), and HIPPO (NF2). Compared to initial tumors, progressive or recurrent tumors involve a distinct set of SSV-gene associations. High overall SSV burden associates with TP53 mutations, histone H3.3 gene H3F3C mutations, and the transcription of DNA damage response genes. Compared to adult cancers, pediatric brain tumors would involve a different set of genes with SSV-altered cis-regulation. Our comprehensive and pan-histology genomic analyses reveal SSVs to play a major role in shaping the transcriptome of pediatric brain tumors.

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