TH-D-210A-04: Monte Carlo Calculations of Microscopic Dose Enhancement Factor for Gold Nanoparticle-Aided Radiation Therapy

2009 ◽  
Vol 36 (6Part28) ◽  
pp. 2819-2819
Author(s):  
B Jones ◽  
S Krishnan ◽  
S Cho
Keyword(s):  
Monte Carlo ◽  
Radiation Therapy ◽  
Gold Nanoparticle ◽  
Enhancement Factor ◽  
Dose Enhancement ◽  
Monte Carlo Calculations

Estimation of microscopic dose enhancement factor around gold nanoparticles by Monte Carlo calculations

2010 ◽  
Vol 37 (7Part1) ◽  
pp. 3809-3816 ◽  
Author(s):  
Bernard L. Jones ◽  
Sunil Krishnan ◽  
Sang Hyun Cho
Keyword(s):  
Gold Nanoparticles ◽  
Monte Carlo ◽  
Enhancement Factor ◽  
Dose Enhancement ◽  
Monte Carlo Calculations

A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale

2021 ◽  
Vol 171 ◽  
pp. 109638
Author(s):  
Tara Gray ◽  
Nema Bassiri ◽  
Shaquan David ◽  
Devanshi Yogeshkumar Patel ◽  
Sotirios Stathakis ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Gold Nanoparticle ◽  
Monte Carlo Analysis ◽  
External Beam ◽  
Macroscopic Scale ◽  
Dose Enhancement

scholarly journals Study of Radiation Dose Enhancement to Capillary Endothelial Cells Due to the Presence of Heavy Metal Nanoparticles in Two Cell and Tumor Scales by Monte Carlo Method

2020 ◽  
Author(s):  
Aghdas Sohayli-Jabbareh-Naseroo ◽  
Ladan Rezaee
Keyword(s):  
Heavy Metal ◽  
Monte Carlo ◽  
Monte Carlo Method ◽  
Energy Range ◽  
Metal Nanoparticles ◽  
Photon Energy ◽  
Enhancement Factor ◽  
Photon Energy Range ◽  
Dose Increase ◽  
Dose Enhancement

Introduction: Recently, the use of various sensitizers has been used to increase photon-induced doses in brachytherapy. One of these cases is the addition of heavy metal nanoparticles such as gold in the target area, which increases the production of ionizing electrons by increasing the possibility of photoelectric effects, and increases the efficacy of the treatment. In this study, the target of the irradiation was the endothelial cell in the wall of blood capillaries located inside the tumor, which, if destroyed, would result in abnormal blood cell counts and tumor cell death. Methods: The effect of using nanoparticles of gold, silver, bismuth and copper has been evaluated by calculating the dose increase ratio using Geant4 tool that was based on Monte Carlo method. These calculations were performed on two microscopic (cellular) and macroscopic (tumor dimensions) scale and the effects of different concentrations of these nanoparticles were compared. Also, the dose increase ratio has been evaluated to determine the most appropriate photon energy range. Results: As the concentration of nanoparticles increases, the dose enhancement factor increased in photon energy. In addition, for energies less than 70 keV, with increasing energy, dose enhancement factor increased and for energies above 80 keV, this quantity decreased with increasing energy. Conclusion: In terms of dose, gold is the best option, and in terms of the dose enhancement factor, silver and bismuth are better alternative among the four elements studied. Also, the most suitable photon energy range is 70 keV to 80 keV.

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