SU-FF-T-495: Risk Estimation of Radiation Induced Second Cancers in Prostate Cancer Patient Treated by Intensity Modulated Radiotherapy (IMRT) and Three Dimensional Conformal Radiotherapy (3D-CRT)

2009 ◽  
Vol 36 (6Part16) ◽  
pp. 2637-2637
Author(s):  
S Sakulsingharoj ◽  
V Boonkitticharoen ◽  
C Tannanonta ◽  
C Kakanaporn ◽  
P Iampongpaiboon
Keyword(s):  
Prostate Cancer ◽  
Prostate Cancer Patient ◽  
Risk Estimation ◽  
Three Dimensional ◽  
Intensity Modulated Radiotherapy ◽  
Conformal Radiotherapy ◽  
Intensity Modulated ◽  
Radiation Induced ◽  
Three Dimensional Conformal Radiotherapy ◽  
3D Crt

scholarly journals Comparison between Intensity-Modulated Radiotherapy and Three-Dimensional Conformal Radiotherapy for Their Effectiveness in Esophageal Cancer Treatment: A Retrospective Single Institution Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Xing-hua Bai ◽  
Jun Dang ◽  
Zhi-qin Chen ◽  
Zheng He ◽  
Guang Li
Keyword(s):  
Esophageal Cancer ◽  
Radiation Therapy ◽  
Locally Advanced ◽  
Three Dimensional ◽  
Intensity Modulated Radiotherapy ◽  
Conformal Radiotherapy ◽  
Intensity Modulated ◽  
Three Dimensional Conformal Radiotherapy ◽  
3D Crt

Although a large number of influential studies that have been conducted worldwide on locally advanced esophageal cancer (EC) have employed the treatment modality of three-dimensional conformal radiotherapy (3D-CRT), an advanced as well as highly conformal technology known as intensity-modulated radiotherapy (IMRT) has attracted increasing attention from the radiotherapy research community. This is because of the clear advantages of IMRT, including decrease in radiation dose that reaches critical cardiopulmonary organs. These two treatment modalities need to be investigated with regard to their effect on local control rate and patient survival. In addition, related clinical factors also need to be explored. Data from a total of 431 patients with locally advanced EC, who underwent radiation therapy between January 1, 2010 and December 31, 2013, were included in the present study. Two hundred and ninety-three patients received 3D-CRT, while 138 patients received IMRT. We constructed propensity score matches to make the two groups be comparable (136 patients in 3D-CRT group and 138 patients in IMRT group. Kaplan–Meier analysis was conducted to evaluate the endpoint of overall survival (OS). A Cox proportional hazards model was employed to analyze the relationship between the associated factors and the outcomes via univariate and multivariate approaches. The mean follow-up period was 36.2 months, and the median follow-up period was 23 months. For the IMRT group, the median OS was 31 months, and the 1-, 3-, and 5-year OS rates were 70.3%, 50.0%, and 42.8%, respectively, while for the 3D-CRT group, the median OS was 22 months, and the 1-, 3-, and 5-year OS rates were 63.2%, 41.0%, and 35.4%, respectively (p<0.05). The univariate analysis revealed that quit drinking, chemotherapy, and concurrent chemotherapy were significant risk factors for the prognosis of EC (p<0.05), as well as the radiation therapy technique used (p=0.052). The multivariate analysis indicated that chemotherapy and quit drinking were independent predictive factors for OS. OS is found to be significantly better in the IMRT group, compared with that of the 3D-CRT group. Even though these outcomes need further validation, IMRT should be considered preferentially as a therapeutic option for EC, in combination with chemotherapy and persuading patients to quit drinking.

scholarly journals Dosimetric Comparison of Intensity-Modulated Radiotherapy, Volumetric Modulated Arc Therapy and Hybrid Three-Dimensional Conformal Radiotherapy/Intensity-Modulated Radiotherapy Techniques for Right Breast Cancer

2020 ◽  
Vol 9 (12) ◽  
pp. 3884
Author(s):  
Yi-Chi Liu ◽  
Hung-Ming Chang ◽  
Hsin-Hon Lin ◽  
Chia-Chun Lu ◽  
Lu-Han Lai
Keyword(s):  
Volumetric Modulated Arc Therapy ◽  
Three Dimensional ◽  
Intensity Modulated Radiotherapy ◽  
Conformal Radiotherapy ◽  
Whole Body ◽  
Intensity Modulated ◽  
Arc Therapy ◽  
Effective Doses ◽  
Three Dimensional Conformal Radiotherapy ◽  
3D Crt

This study aimed to compare different types of right breast cancer radiotherapy planning techniques and to estimate the whole-body effective doses and the critical organ absorbed doses. The three planning techniques are intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT; two methods) and hybrid 3D-CRT/IMRT (three-dimensional conformal radiotherapy/intensity-modulated radiotherapy). The VMAT technique includes two methods to deliver a dose: non-continuous partial arc and continuous partial arc. A thermoluminescent dosimeter (TLD) is placed in the RANDO phantom to estimate the organ absorbed dose. Each planning technique applies 50.4 Gy prescription dose and treats critical organs, including the lung and heart. Dose-volume histogram was used to show the planning target volume (V95%), homogeneity index (HI), conformity index (CI), and other optimized indices. The estimation of whole-body effective dose was based on the International Commission on Radiation Protection (ICRP) Publication 60 and 103. The results were as follows: Continuous partial arc and non-continuous partial arc showed the best CI and HI. The heart absorbed doses in the continuous partial arc and hybrid 3D-CRT/IMRT were 0.07 ± 0.01% and 0% (V5% and V10%, respectively). The mean dose of the heart was lowest in hybrid 3D-CRT/IMRT (1.47 Gy ± 0.02). The dose in the left contralateral lung (V5%) was lowest in continuous partial arc (0%). The right ipsilateral lung average dose and V20% are lowest in continuous partial arc. Hybrid 3D-CRT/IMRT has the lowest mean dose to contralateral breast (organs at risk). The whole-body effective doses for ICRP-60 and ICRP-103 were highest in continuous partial arc (2.01 Sv ± 0.23 and 2.89 Sv ± 0.15, respectively). In conclusion, the use of VMAT with continuous arc has a lower risk of radiation pneumonia, while hybrid 3D-CRT/IMRT attain lower secondary malignancy risk and cardiovascular complications.

Sign in / Sign up

Export Citation Format

Share Document