GafChromic EBT film dosimetry with flatbed CCD scanner: A novel background correction method and full dose uncertainty analysis

2008 ◽  
Vol 35 (7Part1) ◽  
pp. 3094-3101 ◽  
Author(s):  
Sigrun Saur ◽  
Jomar Frengen
1983 ◽  
Vol 37 (5) ◽  
pp. 419-424 ◽  
Author(s):  
S. B. Smith ◽  
G. M. Hieftje

A new method is described and tested for background correction in atomic absorption spectrometry. Applicable to flame or furnace atomizers, the method is capable of correcting backgrounds caused by molecular absorption, particulate scattering, and atomic-line overlap, even up to an absorbance value of 3. Like the Zeeman approach, the new method applies its correction very near the atomic line of interest, can employ single-beam optics, and requires no auxiliary source. However, no ancillary magnet or other costly peripherals are required and working curves are single-valued. The new technique is based on the broadening which occurs in a hollow-cathode spectral line when the lamp is operated at high currents. Under such conditions, the absorbance measured for a narrow (atomic) line is low, whereas the apparent absorbance caused by a broad-band background contributor remains as high as when the lamp is operated at conventional current levels. Background correction can therefore be effected by taking the difference in absorbances measured with the lamp operated at high and low currents. The new technique is evaluated in its ability to correct several different kinds of background interference and is critically compared with competitive methods.


2013 ◽  
Vol 44 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Cynthia K. Rigsby ◽  
Nicholas Hilpipre ◽  
Gary R. McNeal ◽  
Gang Zhang ◽  
Emma E. Boylan ◽  
...  

2020 ◽  
Author(s):  
Domenico Finocchiaro ◽  
Jonathan I Gear ◽  
Federica Fioroni ◽  
Glenn D Flux ◽  
Iain Murray ◽  
...  

Abstract Background Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly ignored in clinical routine. However, it is essential for adequate interpretation of the results. Recently, the EANM published a practical guidance on uncertainty analysis for molecular radiotherapy based on the application of the law of propagation of uncertainty. In this study, we investigated the overall uncertainty on a large sample of patient following the EANM guidelines. The aim of this study was to provide an indication of the typical uncertainties that may be expected from performing dosimetry, to determine parameters that have the greatest effect on the accuracy of calculations and to consider the potential improvements that could be made if these effects were reduced. Results Absorbed doses and the relative uncertainties were calculated for a sample of 49 patients and a total of 154 tumours. A wide range of relative dose uncertainty values was observed (14 - 102%). Uncertainties associated to each quantity along the dose calculation chain (i.e. Volume, Recovery Coefficient, Calibration Factor, Activity, Time-Activity Curve Fitting, Cumulated Activity and Absorbed Dose) were estimated. An equation was derived to describe relationship between the uncertainty in the absorbed dose and the volume. The largest source of error was the VOI delineation. By postulating different values of FHWM, the impact of the imaging system spatial resolution on the uncertainties was investigated. Discussion To the best of our knowledge, this is the first analysis of uncertainty in MRT based on a large sample of clinical cases. Wide inter-lesion variability of dose uncertainty was observed. Hence, a proper assessment of the uncertainties associated with the calculations should be considered as a basic scientific standard. A model for a quick estimate of uncertainty without implementing the entire error propagation schema, which may be useful in clinical practice, was presented. Ameliorating spatial resolution may be in future the key factor for accurate absorbed dose assessment.


2011 ◽  
Vol 31 (8) ◽  
pp. 0812008
Author(s):  
段亚轩 Duan Yaxuan ◽  
陈永权 Chen Yongquan ◽  
赵建科 Zhao Jianke ◽  
李坤 Li Kun ◽  
龙江波 Long Jiangbo

2012 ◽  
Vol 84 (15) ◽  
pp. 6747-6752 ◽  
Author(s):  
Marcelo R. Filgueira ◽  
Cecilia B. Castells ◽  
Peter W. Carr

2018 ◽  
Vol 47 ◽  
pp. 23-33 ◽  
Author(s):  
Juan Antonio Vera-Sánchez ◽  
Carmen Ruiz-Morales ◽  
Antonio González-López

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