TH-E-M100J-03: Early Tumor Response Assessment of Advanced Head and Neck Cancer Using DCE MRI

2007 ◽  
Vol 34 (6Part24) ◽  
pp. 2649-2649 ◽  
Author(s):  
Y Cao ◽  
S Mukherji ◽  
C Tsien ◽  
T L Chenevert ◽  
A Eisbruch
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tumor Response ◽  
Response Assessment ◽  
Advanced Head ◽  
Dce Mri ◽  
Early Tumor Response ◽  
Early Tumor

Radiation Concurrent With Gemcitabine for Locally Advanced Head and Neck Cancer: A Phase I Trial and Intracellular Drug Incorporation Study

2001 ◽  
Vol 19 (3) ◽  
pp. 792-799 ◽  
Author(s):  
Avraham Eisbruch ◽  
Donna S. Shewach ◽  
Carol R. Bradford ◽  
James F. Littles ◽  
Theodore N. Teknos ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Low Dose ◽  
Tumor Response ◽  
Locally Advanced ◽  
High Rate ◽  
Advanced Head ◽  
Dose Levels ◽  
Complete Tumor

PURPOSE: To examine the feasibility and dose-limiting toxicity (DLT) of once-weekly gemcitabine at doses predicted in preclinical studies to produce radiosensitization, concurrent with a standard course of radiation for locally advanced head and neck cancer. Tumor incorporation of gemcitabine triphosphate (dFdCTP) was measured to assess whether adequate concentrations were achieved at each dose level. PATIENTS AND METHODS: Twenty-nine patients with unresectable head and neck cancer received a course of radiation (70 Gy over 7 weeks, 5 days weekly) concurrent with weekly infusions of low-dose gemcitabine. Tumor biopsies were performed after the first gemcitabine infusion (before radiation started), and the intracellular concentrations of dFdCTP were measured. RESULTS: Severe acute and late mucosal and pharyngeal-related DLT required de-escalation of gemcitabine dose in successive patient cohorts receiving dose levels of 300 mg/m2/wk, 150 mg/m2/wk, and 50 mg/m2/wk. No DLT was observed at 10 mg/m2/wk. The rate of endoscopy- and biopsy-assessed complete tumor response was 66% to 87% in the various cohorts. Tumor dFdCTP levels were similar in patients receiving 50 to 300 mg/m2 (on average, 1.55 pmol/mg, SD 1.15) but were barely or not detectable at 10 mg/m2. CONCLUSION: A high rate of acute and late mucosa-related DLT and a high rate of complete tumor response were observed in this regimen at the dose levels of 50 to 300 mg/m2, which also resulted in similar, subcytotoxic intracellular dFdCTP concentrations. These results demonstrate significant tumor and normal tissue radiosensitization by low-dose gemcitabine. Different regimens of combined radiation and gemcitabine should be evaluated, based on newer preclinical data promising an improved therapeutic ratio.

The prognostic utility of 18F-FDG-PET metabolic tumor response after chemoradiotherapy for locally advanced head and neck cancer

2014 ◽  
Vol 54 (7) ◽  
pp. 1066-1067 ◽  
Author(s):  
Federico Ampil ◽  
Gloria Caldito ◽  
Carolyn Reiser ◽  
Srinivas Devarakonda ◽  
Amol Takalkar ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Fdg Pet ◽  
Tumor Response ◽  
Locally Advanced ◽  
Advanced Head ◽  
Prognostic Utility ◽  
18F Fdg

Preoperative cisplatin and accelerated hyperfractionated radiation induces high tumor response and control rates in patients with advanced head and neck cancer

1995 ◽  
Vol 170 (5) ◽  
pp. 512-516 ◽  
Author(s):  
Harold J. Wanebo ◽  
Arvin S. Glicksman ◽  
Christine Landman ◽  
Gus Slotman ◽  
Charles Doolittle ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tumor Response ◽  
Advanced Head ◽  
And Control
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