scholarly journals The multi-module, multi-resolution system (M3R): A novel small-animal SPECT system

2007 ◽  
Vol 34 (3) ◽  
pp. 987-993 ◽  
Author(s):  
Jacob Y. Hesterman ◽  
Matthew A. Kupinski ◽  
Lars R. Furenlid ◽  
Donald W. Wilson ◽  
Harrison H. Barrett
Keyword(s):  
Small Animal ◽  
Resolution System ◽  
Spect System

scholarly journals Application of Blind Deblurring Reconstruction Technique to SPECT Imaging

2007 ◽  
Vol 2007 ◽  
pp. 1-9 ◽  
Author(s):  
Heng Li ◽  
Yibin Zheng
Keyword(s):  
Experimental Studies ◽  
Small Animal ◽  
Ground Truth ◽  
Reconstruction Algorithm ◽  
Reconstruction Technique ◽  
Spect Image ◽  
Blind Deblurring ◽  
Image Blurring ◽  
Reconstruction Efficiency ◽  
Spect System

An SPECT image can be approximated as the convolution of the ground truth spatial radioactivity with the system point spread function (PSF). The PSF of an SPECT system is determined by the combined effect of several factors, including the gamma camera PSF, scattering, attenuation, and collimator response. It is hard to determine the SPECT system PSF analytically, although it may be measured experimentally. We formulated a blind deblurring reconstruction algorithm to estimate both the spatial radioactivity distribution and the system PSF from the set of blurred projection images. The algorithm imposes certain spatial-frequency domain constraints on the reconstruction volume and the PSF and does not otherwise assume knowledge of the PSF. The algorithm alternates between two iterative update sequences that correspond to the PSF and radioactivity estimations, respectively. In simulations and a small-animal study, the algorithm reduced image blurring and preserved the edges without introducing extra artifacts. The localized measurement shows that the reconstruction efficiency of SPECT images improved more than 50% compared to conventional expectation maximization (EM) reconstruction. In experimental studies, the contrast and quality of reconstruction was substantially improved with the blind deblurring reconstruction algorithm.

scholarly journals rSPECT: A compact gamma camera based SPECT system for small-animal imaging

2009 ◽  
Author(s):  
Eduardo Lage ◽  
Jose L. Villena ◽  
Gustavo Tapias ◽  
I. Vidal-Migallon ◽  
Monica Abella ◽  
...  
Keyword(s):  
Gamma Camera ◽  
Small Animal Imaging ◽  
Small Animal ◽  
Animal Imaging ◽  
Spect System

scholarly journals Capabilities of multi-pinhole SPECT with two stationary detectors for in vivo rat imaging

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jan P. Janssen ◽  
Jan V. Hoffmann ◽  
Takayuki Kanno ◽  
Naoko Nose ◽  
Jan-Peter Grunz ◽  
...  
Keyword(s):  
Image Quality ◽  
Point Source ◽  
Single Photon ◽  
Photon Emission ◽  
Small Animal ◽  
Acquisition Time ◽  
Emission Computed Tomography ◽  
Scan Time ◽  
Spect System

Abstract We aimed to investigate the image quality of the U-SPECT5/CT E-Class a micro single-photon emission computed tomography (SPECT) system with two large stationary detectors for visualization of rat hearts and bones using clinically available 99mTc-labelled tracers. Sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR) of the small-animal SPECT scanner were investigated in phantom studies using an ultra-high-resolution rat and mouse multi-pinhole collimator (UHR-RM). Point source, hot-rod, and uniform phantoms with 99mTc-solution were scanned for high-count performance assessment and count levels equal to animal scans, respectively. Reconstruction was performed using the similarity-regulated ordered-subsets expectation maximization (SROSEM) algorithm with Gaussian smoothing. Rats were injected with ~ 100 MBq [99mTc]Tc-MIBI or ~ 150 MBq [99mTc]Tc-HMDP and received multi-frame micro-SPECT imaging after tracer distribution. Animal scans were reconstructed for three different acquisition times and post-processed with different sized Gaussian filters. Following reconstruction, CNR was calculated and image quality evaluated by three independent readers on a five-point scale from 1 = “very poor” to 5 = “very good”. Point source sensitivity was 567 cps/MBq and radioactive rods as small as 1.2 mm were resolved with the UHR-RM collimator. Collimator-dependent uniformity was 55.5%. Phantom CNR improved with increasing rod size, filter size and activity concentration. Left ventricle and bone structures were successfully visualized in rat experiments. Image quality was strongly affected by the extent of post-filtering, whereas scan time did not have substantial influence on visual assessment. Good image quality was achieved for resolution range greater than 1.8 mm in bone and 2.8 mm in heart. The recently introduced small animal SPECT system with two stationary detectors and UHR-RM collimator is capable to provide excellent image quality in heart and bone scans in a rat using standardized reconstruction parameters and appropriate post-filtering. However, there are still challenges in achieving maximum system resolution in the sub-millimeter range with in vivo settings under limited injection dose and acquisition time.

Performance Evaluation of Stationary and Semi-Stationary Acquisition with a Non-Stationary Small Animal Multi-Pinhole SPECT System

2013 ◽  
Vol 16 (3) ◽  
pp. 311-316 ◽  
Author(s):  
Catharina Lange ◽  
Ivayla Apostolova ◽  
Mathias Lukas ◽  
Kai P. Huang ◽  
Frank Hofheinz ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Small Animal ◽  
Pinhole Spect ◽  
Spect System
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