SU-FF-T-173: Dose Per Monitor Unit Determination for Proton Therapy Treatment Portals with and Without the Range Compensator

2006 ◽  
Vol 33 (6Part9) ◽  
pp. 2088-2089
Author(s):  
J Fontenot ◽  
W Newhauser
Keyword(s):  
Proton Therapy ◽  
Monitor Unit ◽  
Therapy Treatment

SU-FF-T-297: Monitor Unit Calculation in Eclipse Proton Therapy Treatment Planning

2007 ◽  
Vol 34 (6Part12) ◽  
pp. 2470-2470
Author(s):  
R Slopsema ◽  
D Yeung ◽  
S Flampouri ◽  
L Lin ◽  
Z Zhao ◽  
...  
Keyword(s):  
Treatment Planning ◽  
Proton Therapy ◽  
Monitor Unit ◽  
Therapy Treatment

scholarly journals Metallic Nanoparticles: A Useful Prompt Gamma Emitter for Range Monitoring in Proton Therapy?

Radiation ◽  
2021 ◽  
Vol 1 (4) ◽  
pp. 305-316
Author(s):  
Sébastien Penninckx ◽  
Félicien Hespeels ◽  
Julien Smeets ◽  
Julien L. Colaux ◽  
Stéphane Lucas ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Metallic Nanoparticles ◽  
Target Volume ◽  
Prompt Gamma ◽  
Dose Delivery ◽  
Non Invasive ◽  
Safety Margins ◽  
Medical Physicists ◽  
Invasive Techniques ◽  
Therapy Treatment

In clinical practice, dose delivery in proton therapy treatment is affected by uncertainties related to the range of the beam in the patient, which requires medical physicists to introduce safety margins on the penetration depth of the beam. Although this ensures an irradiation of the entire clinical target volume with the prescribed dose, these safety margins also lead to the exposure of nearby healthy tissues and a subsequent risk of side effects. Therefore, non-invasive techniques that allow for margin reduction through online monitoring of prompt gammas emitted along the proton tracks in the patient are currently under development. This study provides the proof-of-concept of metal-based nanoparticles, injected into the tumor, as a prompt gamma enhancer, helping in the beam range verification. It identifies the limitations of this application, suggesting a low feasibility in a realistic clinical scenario but opens some avenues for improvement.

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