Stability of a mobile electron linear accelerator system for intraoperative radiation therapy

2005 ◽  
Vol 32 (10) ◽  
pp. 3128-3131 ◽  
Author(s):  
A. Sam Beddar
Keyword(s):  
Radiation Therapy ◽  
Linear Accelerator ◽  
Intraoperative Radiation Therapy ◽  
Electron Linear Accelerator ◽  
Intraoperative Radiation ◽  
Mobile Electron ◽  
Accelerator System

scholarly journals Radiation survey around a Liac mobile electron linear accelerator for intraoperative radiation therapy

2009 ◽  
Vol 10 (2) ◽  
pp. 131-138 ◽  
Author(s):  
Mario Ciocca ◽  
Guido Pedroli ◽  
Roberto Orecchia ◽  
Andrea Guido ◽  
Federica Cattani ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Linear Accelerator ◽  
Intraoperative Radiation Therapy ◽  
Electron Linear Accelerator ◽  
Intraoperative Radiation ◽  
Mobile Electron

Intraoperative Radiation Therapy in Early Breast Cancer Using a Linear Accelerator Outside of the Operative Suite: An “Image-Guided” Approach

2014 ◽  
Vol 89 (5) ◽  
pp. 1015-1023 ◽  
Author(s):  
Samir Abdallah Hanna ◽  
Alfredo Carlos Simões Dornellas de Barros ◽  
Felipe Eduardo Martins de Andrade ◽  
Jose Luiz Barbosa Bevilacqua ◽  
José Roberto Morales Piato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Early Breast Cancer ◽  
Linear Accelerator ◽  
Intraoperative Radiation Therapy ◽  
Intraoperative Radiation ◽  
Image Guided

scholarly journals Intraoperative radiation therapy using mobile electron linear accelerators: Report of AAPM Radiation Therapy Committee Task Group No. 72

2006 ◽  
Vol 33 (5) ◽  
pp. 1476-1489 ◽  
Author(s):  
A. Sam Beddar ◽  
Peter J. Biggs ◽  
Sha Chang ◽  
Gary A. Ezzell ◽  
Bruce A. Faddegon ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Task Group ◽  
Intraoperative Radiation Therapy ◽  
Linear Accelerators ◽  
Intraoperative Radiation ◽  
Mobile Electron

scholarly journals Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer

2020 ◽  
Vol 62 (1) ◽  
pp. 110-118
Author(s):  
Isabel Linares-Galiana ◽  
Miguel Angel Berenguer-Frances ◽  
Rut Cañas-Cortés ◽  
Monica Pujol-Canadell ◽  
Silvia Comas-Antón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Single Dose ◽  
Cancer Patients ◽  
Antitumor Immunity ◽  
Low Risk ◽  
Intraoperative Radiation Therapy ◽  
Breast Cancer Patients ◽  
Intraoperative Radiation ◽  
Risk Breast Cancer

Abstract A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30–0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients.

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