TH-C-T-6C-10: Simulation of Dosimetric Properties of Very-High Energy Laser-Accelerated Electron Beams

2005 ◽  
Vol 32 (6Part21) ◽  
pp. 2163-2164
Author(s):  
T Fuchs ◽  
H Szymanowski ◽  
Y Glinec ◽  
J Faure ◽  
V Malka ◽  
...  
Keyword(s):  
Electron Beams ◽  
High Energy ◽  
Very High Energy ◽  
Energy Laser ◽  
High Energy Laser ◽  
Very High

scholarly journals Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
L. Whitmore ◽  
R. I. Mackay ◽  
M. van Herk ◽  
J. K. Jones ◽  
R. M. Jones
Keyword(s):  
Electron Beams ◽  
Focal Point ◽  
External Beam Radiotherapy ◽  
High Energy ◽  
Energy Electron ◽  
High Energy Electron ◽  
Dose Delivery ◽  
Entrance Dose ◽  
Very High Energy ◽  
Very High

AbstractThis paper presents the first demonstration of deeply penetrating dose delivery using focused very high energy electron (VHEE) beams using quadrupole magnets in Monte Carlo simulations. We show that the focal point is readily modified by linearly changing the quadrupole magnet strength only. We also present a weighted sum of focused electron beams to form a spread-out electron peak (SOEP) over a target region. This has a significantly reduced entrance dose compared to a proton-based spread-out Bragg peak (SOBP). Very high energy electron (VHEE) beams are an exciting prospect in external beam radiotherapy. VHEEs are less sensitive to inhomogeneities than proton and photon beams, have a deep dose reach and could potentially be used to deliver FLASH radiotherapy. The dose distributions of unfocused VHEE produce high entrance and exit doses compared to other radiotherapy modalities unless focusing is employed, and in this case the entrance dose is considerably improved over existing radiations. We have investigated both symmetric and asymmetric focusing as well as focusing with a range of beam energies.

scholarly journals Very high energy electromagnetically-scanned electron beams are an attractive alternative to photon IMRT

2004 ◽  
Vol 31 (7) ◽  
pp. 1945-1948 ◽  
Author(s):  
Lech Papiez ◽  
Thomas Bortfeld ◽  
William R. Hendee
Keyword(s):  
Electron Beams ◽  
High Energy ◽  
Attractive Alternative ◽  
Very High Energy ◽  
Very High

Characteristics of very high‐energy electron beams for the irradiation of deep‐seated targets

2021 ◽  
Author(s):  
Till Tobias Böhlen ◽  
Jean‐François Germond ◽  
Erik Traneus ◽  
Jean Bourhis ◽  
Marie‐Catherine Vozenin ◽  
...  
Keyword(s):  
Electron Beams ◽  
High Energy ◽  
Energy Electron ◽  
High Energy Electron ◽  
Very High Energy ◽  
Very High

scholarly journals Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
K. Kokurewicz ◽  
E. Brunetti ◽  
G. H. Welsh ◽  
S. M. Wiggins ◽  
M. Boyd ◽  
...  
Keyword(s):  
Electron Beams ◽  
High Energy ◽  
Energy Electron ◽  
High Dose ◽  
High Energy Electron ◽  
Very High Energy ◽  
Very High

scholarly journals First theoretical determination of relative biological effectiveness of very high energy electrons

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rachel Delorme ◽  
Thongchai A. M. Masilela ◽  
Camille Etoh ◽  
François Smekens ◽  
Yolanda Prezado
Keyword(s):  
Electron Beams ◽  
Rapid Development ◽  
High Energy ◽  
High Dose ◽  
Clinical Implementation ◽  
Biological Efficacy ◽  
Lineal Energy ◽  
High Energy Electrons ◽  
Very High Energy ◽  
Very High

AbstractVery high energy electrons (VHEEs, E > 70 MeV) present promising clinical advantages over conventional beams due to their increased range, improved penumbra and relative insensitivity to tissue heterogeneities. They have recently garnered additional interest in their application to spatially fractionated radiotherapy or ultra-high dose rate (FLASH) therapy. However, the lack of radiobiological data limits their rapid development. This study aims to provide numerical biologically-relevant information by characterizing VHEE beams (100 and 300 MeV) against better-known beams (clinical energy electrons, photons, protons, carbon and neon ions). Their macro- and microdosimetric properties were compared, using the dose-averaged linear energy transfer ($$\overline{{L_{d} }}$$ L d ¯ ) as the macroscopic metric, and the dose-mean lineal energy $$\overline{{y_{d} }}$$ y d ¯ and the dose-weighted lineal energy distribution, yd(y), as microscopic metrics. Finally, the modified microdosimetric kinetic model was used to calculate the respective cell survival curves and the theoretical RBE. From the macrodosimetric point of view, VHEEs presented a potential improved biological efficacy over clinical photon/electron beams due to their increased $$\overline{{L_{d} }}$$ L d ¯ . The microdosimetric data, however, suggests no increased biological efficacy of VHEEs over clinical electron beams, resulting in RBE values of approximately 1, giving confidence to their clinical implementation. This study represents a first step to complement further radiobiological experiments.

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