Therapeutic treatment plan optimization with probability density-based dose prescription

2003 ◽  
Vol 30 (4) ◽  
pp. 655-666 ◽  
Author(s):  
Jun Lian ◽  
Cristian Cotrutz ◽  
Lei Xing
Keyword(s):  
Probability Density ◽  
Treatment Plan ◽  
Therapeutic Treatment ◽  
Plan Optimization ◽  
Treatment Plan Optimization

scholarly journals A comparison of two methodologies for radiotherapy treatment plan optimization and QA for clinical trials

2021 ◽  
Vol 22 (10) ◽  
pp. 329-337
Author(s):  
Huaizhi Geng ◽  
Tawfik Giaddui ◽  
Chingyun Cheng ◽  
Haoyu Zhong ◽  
Samuel Ryu ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Treatment Plan ◽  
Plan Optimization ◽  
Treatment Plan Optimization ◽  
Radiotherapy Treatment

OC-0106: Stepwise model-based treatment plan optimization to prevent dypshagia.in head and neck cancer.

2020 ◽  
Vol 152 ◽  
pp. S51-S52
Author(s):  
H. Langendijk ◽  
L. Van den Bosch ◽  
A. Van den Hoek ◽  
E. Oldehinkel ◽  
T. Meijer ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Treatment Plan ◽  
Model Based ◽  
Plan Optimization ◽  
Treatment Plan Optimization

scholarly journals Nanodosimetry-Based Plan Optimization for Particle Therapy

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Margherita Casiraghi ◽  
Reinhard W. Schulte
Keyword(s):  
Treatment Plan ◽  
Target Volume ◽  
Particle Therapy ◽  
Optimization Strategy ◽  
Plan Optimization ◽  
Treatment Plan Optimization ◽  
Treatment Plans ◽  
Mixed Field ◽  
Single Field ◽  
Mixed Radiation Field

Treatment planning for particle therapy is currently an active field of research due uncertainty in how to modify physical dose in order to create a uniform biological dose response in the target. A novel treatment plan optimization strategy based on measurable nanodosimetric quantities rather than biophysical models is proposed in this work. Simplified proton and carbon treatment plans were simulated in a water phantom to investigate the optimization feasibility. Track structures of the mixed radiation field produced at different depths in the target volume were simulated with Geant4-DNA and nanodosimetric descriptors were calculated. The fluences of the treatment field pencil beams were optimized in order to create a mixed field with equal nanodosimetric descriptors at each of the multiple positions in spread-out particle Bragg peaks. For both proton and carbon ion plans, a uniform spatial distribution of nanodosimetric descriptors could be obtained by optimizing opposing-field but not single-field plans. The results obtained indicate that uniform nanodosimetrically weighted plans, which may also be radiobiologically uniform, can be obtained with this approach. Future investigations need to demonstrate that this approach is also feasible for more complicated beam arrangements and that it leads to biologically uniform response in tumor cells and tissues.

scholarly journals A new column-generation-based algorithm for VMAT treatment plan optimization

2012 ◽  
Vol 57 (14) ◽  
pp. 4569-4588 ◽  
Author(s):  
Fei Peng ◽  
Xun Jia ◽  
Xuejun Gu ◽  
Marina A Epelman ◽  
H Edwin Romeijn ◽  
...  
Keyword(s):  
Column Generation ◽  
Treatment Plan ◽  
Plan Optimization ◽  
Treatment Plan Optimization
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