Toward clinical application of prompt gamma spectroscopy forin vivomonitoring of boron uptake in boron neutron capture therapy

2001 ◽  
Vol 28 (5) ◽  
pp. 787-795 ◽  
Author(s):  
P. M. Munck af Rosenschöld ◽  
W. F. A. R. Verbakel ◽  
C. P. Ceberg ◽  
F. Stecher-Rasmussen ◽  
B. R. R. Persson
Keyword(s):  
Clinical Application ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Gamma Spectroscopy ◽  
Prompt Gamma ◽  
Neutron Capture Therapy ◽  
Boron Uptake ◽  
Boron Neutron Capture

scholarly journals P13.09 * ADVANCES IN CLINICAL APPLICATION OF BORON NEUTRON CAPTURE THERAPY (BNCT) IN GLIOBLASTOMA

2014 ◽  
Vol 16 (suppl 2) ◽  
pp. ii67-ii67
Author(s):  
A. Detta ◽  
G. C. Cruickshank ◽  
S. Green ◽  
N. P. Lockyer ◽  
D. Ngoga ◽  
...  
Keyword(s):  
Clinical Application ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

TU-FG-BRB-07: GPU-Based Prompt Gamma Ray Imaging From Boron Neutron Capture Therapy

2016 ◽  
Vol 43 (6Part35) ◽  
pp. 3757-3757
Author(s):  
S Kim ◽  
T Suh ◽  
D Yoon ◽  
J Jung ◽  
H Shin ◽  
...  
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Gamma Ray ◽  
Prompt Gamma ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Gamma Ray Imaging

Boron uptake measurements in a rat model for Boron Neutron Capture Therapy of lung tumours

2011 ◽  
Vol 69 (2) ◽  
pp. 394-398 ◽  
Author(s):  
S. Bortolussi ◽  
J.G. Bakeine ◽  
F. Ballarini ◽  
P. Bruschi ◽  
M.A. Gadan ◽  
...  
Keyword(s):  
Rat Model ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Uptake ◽  
Lung Tumours ◽  
Boron Neutron Capture

scholarly journals YC-1 sensitizes the antitumor effects of boron neutron capture therapy in hypoxic tumor cells

2020 ◽  
Vol 61 (4) ◽  
pp. 524-534
Author(s):  
Takaomi Harada ◽  
Katsumi Hirose ◽  
Yuki Wada ◽  
Mariko Sato ◽  
Koji Ichise ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Uptake ◽  
Antitumor Effects ◽  
Hypoxic Conditions ◽  
Boron Neutron Capture ◽  
Hypoxic Tumor ◽  
In Cells

Abstract The uptake of boron into tumor cells is a key factor in the biological effects of boron neutron capture therapy (BNCT). The uptake of boron agents is suppressed in hypoxic conditions, but the mechanism of hypoxia-induced modulation of suppression of boron uptake is not clear. Therefore, we evaluated whether hypoxia-inducible factor 1α (HIF-1α) contributes to attenuation of the antitumor effects of BNCT in hypoxic tumor cells. We also tested whether YC-1, a HIF-1α-targeting inhibitor, has therapeutic potential with BNCT. To elucidate the mechanism of attenuation of the effects of BNCT caused by hypoxia, deferoxamine (DFO) was used in experiments. Cells were incubated in normal oxygen, hypoxic conditions (1% O2) or 5 μM DFO for 24 h. Then, cells were treated with 10B-boronophenylalanine (BPA) for 2 h and boron accumulation in cells was evaluated. To clarify the relationship between HIF-1α and L-type amino acid transporter 1 (LAT1), gene expression was evaluated by a using HIF-1α gene knockdown technique. Finally, to improve attenuation of the effects of BNCT in hypoxic cells, BNCT was combined with YC-1. Boron uptake was continuously suppressed up to 2 h after administration of BPA by 5 μM DFO treatment. In cells treated with 5 μM DFO, LAT1 expression was restored in HIF-1α-knocked down samples in all cell lines, revealing that HIF-1α suppresses LAT1 expression in hypoxic cells. From the results of the surviving fraction after BNCT combined with YC-1, treatment with YC-1 sensitized the antitumor effects of BNCT in cells cultured in hypoxia.

scholarly journals GPU-based prompt gamma ray imaging from boron neutron capture therapy

2014 ◽  
Vol 42 (1) ◽  
pp. 165-169 ◽  
Author(s):  
Do-Kun Yoon ◽  
Joo-Young Jung ◽  
Key Jo Hong ◽  
Keum Sil Lee ◽  
Tae Suk Suh
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Gamma Ray ◽  
Prompt Gamma ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Gamma Ray Imaging

Toward a clinical application of ex situ boron neutron capture therapy for lung tumors at the RA-3 reactor in Argentina

2015 ◽  
Vol 42 (7) ◽  
pp. 4161-4173 ◽  
Author(s):  
R. O. Farías ◽  
M. A. Garabalino ◽  
S. Ferraris ◽  
J. Santa María ◽  
O. Rovati ◽  
...  
Keyword(s):  
Clinical Application ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Lung Tumors ◽  
Ex Situ ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture
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