Ultrafast Nonlinear Laser Spectroscopy: The Role Of Inertia In The Femtosecond Dynamics Of The Optical Kerr Effect In Molecular Liquids

1987 ◽  
Author(s):  
Geraldine A. Kenney-Wallace ◽  
Dale McMorrow ◽  
William T. Lotshaw ◽  
Constantinos Kalpouzos ◽  
Robert Kitchenham
Keyword(s):  
Laser Spectroscopy ◽  
Kerr Effect ◽  
Optical Kerr Effect ◽  
Molecular Liquids ◽  
Femtosecond Dynamics ◽  
Nonlinear Laser Spectroscopy

Assessing the Role of Moment of Inertia in Optical Kerr Effect Spectroscopy

2010 ◽  
Vol 114 (37) ◽  
pp. 12096-12103 ◽  
Author(s):  
Katherine Manfred ◽  
XiaoXiao He ◽  
John T. Fourkas
Keyword(s):  
Kerr Effect ◽  
Moment Of Inertia ◽  
Optical Kerr Effect

scholarly journals Low-frequency vibrational modes in G-quadruplexes reveal the mechanical properties of nucleic acids

2020 ◽  
Author(s):  
M. González-Jiménez ◽  
G. Ramakrishnan ◽  
K. Wynne
Keyword(s):  
Protein Interactions ◽  
Kerr Effect ◽  
Biological Function ◽  
Low Frequency ◽  
Theoretical Models ◽  
Protein Recognition ◽  
Optical Kerr Effect ◽  
Vibrational Modes ◽  
New Perspective

AbstractLow-frequency vibrations play an essential role in biomolecular processes involving DNA such as gene expression, charge transfer, drug intercalation, and DNA–protein recognition. However, understanding of the vibrational basis of these mechanisms relies on theoretical models due to the lack of experimental evidence. Here we present the low-frequency vibrational spectra of G-quadruplexes (structures formed by four strands of DNA) and B-DNA characterized using femtosecond optical Kerr-effect spectroscopy. Contrary to expectation, we found that G-quadruplexes show several strongly underdamped delocalized phonon-like modes that have the potential to contribute to the biology of the DNA at the atomic level. In addition, G-quadruplexes present modes at a higher frequency than B-DNA demonstrating that changes in the stiffness of the molecule alter its gigahertz to terahertz vibrational profile. These results demonstrate that current theoretical models fail to predict basic properties of the vibrational modes of DNA.Statement of significanceA number of recent studies have identified thermally excited low-frequency vibrational modes as a key deciding factor in the biological function of DNA. However, the nature of these vibrational modes has never been established. Here, vibrational spectroscopy with unrivalled signal-to-noise in the gigahertz to terahertz range is used to determine the low-frequency Raman spectra of nucleotides and oligomeric DNAs carefully chosen to form G-quadruplexes, structures formed by four strands of DNA common in the genome. These G-quadruplexes exhibit an unusual group of highly-underdamped delocalized vibrational modes—not reproduced by any of the theoretical models in use—which are expected to be the thermally excited. This provides a new perspective on the role of low-frequency vibrational modes in protein interactions and allostery.

scholarly journals The Role of Intermolecular Interactions in the Electro-Optical Kerr Effect in Liquid Alkanes

2005 ◽  
Vol 108 (3) ◽  
pp. 429-447 ◽  
Author(s):  
O.V. Prezhdo ◽  
L. Switek ◽  
V.V. Zubkova ◽  
V.V. Prezhdo
Keyword(s):  
Intermolecular Interactions ◽  
Kerr Effect ◽  
Optical Kerr Effect ◽  
Liquid Alkanes

Femtosecond dynamics of the optical kerr effect in liquid nitrobenzene and chlorobenzene

1987 ◽  
Vol 136 (3-4) ◽  
pp. 323-328 ◽  
Author(s):  
William T. Lotshaw ◽  
Dale McMorrow ◽  
Constantinos Kalpouzos ◽  
Geraldine A. Kenney-Wallace
Keyword(s):  
Kerr Effect ◽  
Optical Kerr Effect ◽  
Femtosecond Dynamics
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