Optical Determination Of The Thermodynamic Phase Diagram Of A Metamagnet

1977 ◽  
Author(s):  
William C. Egbert
Keyword(s):  
Phase Diagram ◽  
Optical Determination ◽  
Thermodynamic Phase Diagram ◽  
Thermodynamic Phase

scholarly journals Thermodynamic phase diagram of amyloid-β (16–22) peptide

2019 ◽  
Vol 116 (6) ◽  
pp. 2091-2096 ◽  
Author(s):  
Yiming Wang ◽  
Samuel J. Bunce ◽  
Sheena E. Radford ◽  
Andrew J. Wilson ◽  
Stefan Auer ◽  
...  
Keyword(s):  
Phase Diagram ◽  
In Silico ◽  
Amyloid Β ◽  
Solution Phase ◽  
Coarse Grained ◽  
Amyloid Β Protein ◽  
Aβ Peptide ◽  
Thermodynamic Phase Diagram ◽  
Thermodynamic Phase

The aggregation of monomeric amyloid β protein (Aβ) peptide into oligomers and amyloid fibrils in the mammalian brain is associated with Alzheimer’s disease. Insight into the thermodynamic stability of the Aβ peptide in different polymeric states is fundamental to defining and predicting the aggregation process. Experimental determination of Aβ thermodynamic behavior is challenging due to the transient nature of Aβ oligomers and the low peptide solubility. Furthermore, quantitative calculation of a thermodynamic phase diagram for a specific peptide requires extremely long computational times. Here, using a coarse-grained protein model, molecular dynamics (MD) simulations are performed to determine an equilibrium concentration and temperature phase diagram for the amyloidogenic peptide fragment Aβ16–22. Our results reveal that the only thermodynamically stable phases are the solution phase and the macroscopic fibrillar phase, and that there also exists a hierarchy of metastable phases. The boundary line between the solution phase and fibril phase is found by calculating the temperature-dependent solubility of a macroscopic Aβ16–22fibril consisting of an infinite number of β-sheet layers. This in silico determination of an equilibrium (solubility) phase diagram for a real amyloid-forming peptide, Aβ16–22, over the temperature range of 277–330 K agrees well with fibrillation experiments and transmission electron microscopy (TEM) measurements of the fibril morphologies formed. This in silico approach of predicting peptide solubility is also potentially useful for optimizing biopharmaceutical production and manufacturing nanofiber scaffolds for tissue engineering.

Thermodynamic phase diagram analysis of three binary systems shared by five neopentane derivatives

Calphad ◽  
1994 ◽  
Vol 18 (4) ◽  
pp. 387-396 ◽  
Author(s):  
D.O. López ◽  
J. Van Braak ◽  
J.L.L. Tamarit ◽  
H.A.J. Oonk
Keyword(s):  
Phase Diagram ◽  
Binary Systems ◽  
Thermodynamic Phase Diagram ◽  
Thermodynamic Phase ◽  
Diagram Analysis

Thermodynamic Phase Diagram, Half-Metallic and Optical Properties of the Zr2TiSi [111] Films Based on DFT

Silicon ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2165-2178
Author(s):  
Nosrat-Ali Vahabzadeh ◽  
Arash Boochani ◽  
Seyed Mohammad Elahi ◽  
Hossein Akbari
Keyword(s):  
Phase Diagram ◽  
Optical Properties ◽  
Half Metallic ◽  
Thermodynamic Phase Diagram ◽  
Thermodynamic Phase

Thermodynamic Phase Diagram Calculations and Cryoscopic Measurements in the NaCl-CaCl2-MgCl2-CaF2 System

2001 ◽  
Vol 40 (1) ◽  
pp. 33-45 ◽  
Author(s):  
H. Mediaas ◽  
P. Chartrand ◽  
O. Tkatcheva ◽  
A.D. Pelton ◽  
T. Østvold
Keyword(s):  
Phase Diagram ◽  
Thermodynamic Phase Diagram ◽  
Thermodynamic Phase

Optical determination of the magnetic phase diagram and critical exponents of DyPO4

Physica B+C ◽  
1977 ◽  
Vol 86-88 ◽  
pp. 599-601 ◽  
Author(s):  
M. Regis ◽  
J. Ferre ◽  
Y. Farge ◽  
I.R. Jahn
Keyword(s):  
Phase Diagram ◽  
Critical Exponents ◽  
Magnetic Phase ◽  
Magnetic Phase Diagram ◽  
Optical Determination

scholarly journals Invariants in the Yukawa system's thermodynamic phase diagram

2015 ◽  
Vol 22 (7) ◽  
pp. 073705 ◽  
Author(s):  
Arno A. Veldhorst ◽  
Thomas B. Schrøder ◽  
Jeppe C. Dyre
Keyword(s):  
Phase Diagram ◽  
Thermodynamic Phase Diagram ◽  
Thermodynamic Phase
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