Portable guided-mode resonance biosensor platform for point-of-care testing

2012 ◽  
Author(s):  
Gun Yong Sung ◽  
Wan-Joong Kim ◽  
Hyunsung Ko ◽  
Bong K. Kim ◽  
Kyung-Hyun Kim ◽  
...  
Keyword(s):  
Point Of Care ◽  
Point Of Care Testing ◽  
Guided Mode ◽  
Guided Mode Resonance

scholarly journals Toward spectrometerless instant Raman identification with tailored metasurfaces-powered guided-mode resonances (GMR) filters

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mohamed A. Mousa ◽  
Nadia H. Rafat ◽  
Amr A. E. Saleh
Keyword(s):  
Point Of Care ◽  
Cost Effective ◽  
Transmission Efficiency ◽  
Guided Mode ◽  
Point Of Care Diagnostics ◽  
Identification Approach ◽  
Pharmaceutical Industries ◽  
Guided Mode Resonance ◽  
New Generation

Abstract Raman identification is an instrumental tool with a broad range of applications, yet current spectroscopy approaches fall short in facilitating practical and scalable Raman identification platforms. In this work, we introduce a spectrometerless Raman identification approach that utilizes guided-mode resonance filters. Unlike arrayed narrowband-filters spectrometer, we tailor the transmission characteristics of each filter to match the Raman signature of a given target. Hence, instantaneous Raman identification could be directly achieved at the hardware level with no spectral data post-processing. The filters consist of a metasurface grating encapsulated between two identical distributed Bragg reflectors and are characterized by transmission peaks line-widths narrower than 0.01 nm and transmission efficiency exceeding 98%. We develop a rigorous design methodology to customize the filters’ characteristics such that the maximum optical transmission through a given filter is only attained when exposed to the Raman scattering from its matched target. To illustrate the potential of our approach, we theoretically investigate the identification of four different saccharides as well as the classification of two antibiotic-susceptible and resistant strains of Staphylococcus aureus. We show that our proposed approach can accurately identify these targets. Our work lays the foundation for a new-generation of scalable, compact, and cost-effective instant Raman identification platforms that can be adopted in countless applications from wearables and point-of-care diagnostics to in-line quality control in food and pharmaceutical industries.

scholarly journals Rapid and Highly Sensitive Detection of C-Reaction Protein Using Robust Self-Compensated Guided-Mode Resonance BioSensing System for Point-Of-Care Applications

Biosensors ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 523
Author(s):  
Chu-Tung Yeh ◽  
Devesh Barshilia ◽  
Chia-Jui Hsieh ◽  
Hsun-Yuan Li ◽  
Wen-Hsin Hsieh ◽  
...  
Keyword(s):  
Light Source ◽  
Transverse Electric ◽  
Point Of Care ◽  
Low Cost ◽  
Polarized Light ◽  
Transverse Magnetic ◽  
Sensitive Detection ◽  
Guided Mode ◽  
Guided Mode Resonance ◽  
Biosensing System

The rapid and sensitive detection of human C-reactive protein (CRP) in a point-of-care (POC) may be conducive to the early diagnosis of various diseases. Biosensors have emerged as a new technology for rapid and accurate detection of CRP for POC applications. Here, we propose a rapid and highly stable guided-mode resonance (GMR) optofluidic biosensing system based on intensity detection with self-compensation, which substantially reduces the instability caused by environmental factors for a long detection time. In addition, a low-cost LED serving as the light source and a photodetector are used for intensity detection and real-time biosensing, and the system compactness facilitates POC applications. Self-compensation relies on a polarizing beam splitter to separate the transverse-magnetic-polarized light and transverse-electric-polarized light from the light source. The transverse-electric-polarized light is used as a background signal for compensating noise, while the transverse-magnetic-polarized light is used as the light source for the GMR biosensor. After compensation, noise is drastically reduced, and both the stability and performance of the system are enhanced over a long period. Refractive index experiments revealed a resolution improvement by 181% when using the proposed system with compensation. In addition, the system was successfully applied to CRP detection, and an outstanding limit of detection of 1.95 × 10−8 g/mL was achieved, validating the proposed measurement system for biochemical reaction detection. The proposed GMR biosensing sensing system can provide a low-cost, compact, rapid, sensitive, and highly stable solution for a variety of point-of-care applications.

scholarly journals Gradient Waveguide Thickness Guided-Mode Resonance Biosensor

Sensors ◽  
2021 ◽  
Vol 21 (2) ◽  
pp. 376
Author(s):  
Jia-Ming Yang ◽  
Nien-Zu Yang ◽  
Cheng-Hao Chen ◽  
Cheng-Sheng Huang
Keyword(s):  
Optical Sensors ◽  
Spatial Information ◽  
Limit Of Detection ◽  
Point Of Care ◽  
Optical Path ◽  
Fluorescence Measurement ◽  
Buffer Solution ◽  
Guided Mode ◽  
Path Design ◽  
Guided Mode Resonance

Portable systems for detecting biomolecules have attracted considerable attention, owing to the demand for point-of-care testing applications. This has led to the development of lab-on-a-chip (LOC) devices. However, most LOCs are developed with a focus on automation and preprocessing of samples; fluorescence measurement, which requires additional off-chip detection instruments, remains the main detection method in conventional assays. By incorporating optical biosensors into LOCs, the biosensing system can be simplified and miniaturized. However, many optical sensors require an additional coupling device, such as a grating or prism, which complicates the optical path design of the system. In this study, we propose a new type of biosensor based on gradient waveguide thickness guided-mode resonance (GWT-GMR), which allows for the conversion of spectral information into spatial information such that the output signal can be recorded on a charge-coupled device for further analysis without any additional dispersive elements. A two-channel microfluidic chip with embedded GWT-GMRs was developed to detect two model assays in a buffer solution: albumin and creatinine. The results indicated that the limit of detection for albumin was 2.92 μg/mL for the concentration range of 0.8–500 μg/mL investigated in this study, and that for creatinine it was 12.05 μg/mL for the concentration range of 1–10,000 μg/mL. These results indicated that the proposed GWT-GMR sensor is suitable for use in clinical applications. Owing to its simple readout and optical path design, the GWT-GMR is considered ideal for integration with smartphones or as miniaturized displays in handheld devices, which could prove beneficial for future point-of-care applications.

Magnetic Digital Microfluidics for Point-of-Care Testing: Where Are We Now?

2020 ◽  
Vol 27 ◽  
Author(s):  
Yi Zhang
Keyword(s):  
System Integration ◽  
Diagnostic Tests ◽  
Point Of Care ◽  
Digital Microfluidics ◽  
Controlled Environment ◽  
Point Of Care Testing ◽  
Microfluidic Platforms ◽  
Interface System ◽  
Technical Issues ◽  
Sample System

: Point-of-care (POC) testing decentralizes the diagnostic tests to the sites near the patient. Many POC tests rely microfluidic platforms for sample-to-answer analysis. Compared to other microfluidic systems, magnetic digital microfluidics demonstrate compelling advantages for POC diagnostics. In this review, we have examined the capability of magnetic digital microfluidics-based POC diagnostic platforms. More importantly, we have categorized POC settings into three classes based on “where is the point”, “who to care” and “how to test”, and evaluated the suitability of magnetic digital microfluidics in various POC settings. Furthermore, we have addressed other technical issues associated with POC testing such as controlled environment, sample-system interface, system integration and information connectivity. We hope this review would provide a guideline for the future development of magnetic digital microfluidics-based platforms for POC testing.

Enhanced light trapping in Ge-on-Si-on-insulator photodetector by guided mode resonance effect

2018 ◽  
Vol 124 (5) ◽  
pp. 053101
Author(s):  
Zhi Liu ◽  
Jietao Liu ◽  
Buwen Cheng ◽  
Jun Zheng ◽  
Chuanbo Li ◽  
...  
Keyword(s):  
Light Trapping ◽  
Resonance Effect ◽  
Guided Mode ◽  
Guided Mode Resonance
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