Breast tissue composition and breast density measurements from ultrasound tomography

2012 ◽  
Author(s):  
Mark Sak ◽  
Neb Duric ◽  
Norman Boyd ◽  
Peter Littrup ◽  
Erik West ◽  
...  
Keyword(s):  
Breast Density ◽  
Breast Tissue ◽  
Tissue Composition ◽  
Ultrasound Tomography ◽  
Density Measurements

scholarly journals Breast density measurements using ultrasound tomography for patients undergoing tamoxifen treatment

2013 ◽  
Author(s):  
Mark Sak ◽  
Neb Duric ◽  
Peter Littrup ◽  
Cuiping Li ◽  
Lisa Bey-Knight ◽  
...  
Keyword(s):  
Breast Density ◽  
Tamoxifen Treatment ◽  
Ultrasound Tomography ◽  
Density Measurements

Comparison of breast density measurements made using ultrasound tomography and mammography

2015 ◽  
Author(s):  
Mark Sak ◽  
Neb Duric ◽  
Peter Littrup ◽  
Lisa Bey-Knight ◽  
Mark Krycia ◽  
...  
Keyword(s):  
Breast Density ◽  
Ultrasound Tomography ◽  
Density Measurements

scholarly journals Breast density measurements with ultrasound tomography: A comparison with film and digital mammography

2013 ◽  
Vol 40 (1) ◽  
pp. 013501 ◽  
Author(s):  
Neb Duric ◽  
Norman Boyd ◽  
Peter Littrup ◽  
Mark Sak ◽  
Lukasz Myc ◽  
...  
Keyword(s):  
Breast Density ◽  
Digital Mammography ◽  
Ultrasound Tomography ◽  
Density Measurements

scholarly journals Breast density measurements with ultrasound tomography: a comparison with non-contrast MRI

2015 ◽  
Vol 17 (S1) ◽  
Author(s):  
Elizabeth O'Flynn ◽  
Jeremie Fromageau ◽  
Minty Ledger ◽  
Alessandro Messa ◽  
Ashley D'Aquino ◽  
...  
Keyword(s):  
Breast Density ◽  
Ultrasound Tomography ◽  
Density Measurements

scholarly journals Correlation analysis of resected breast tissue and implant volume after mastectomy and its association with breast density

2021 ◽  
Author(s):  
Wolfram Malter ◽  
Bo Jan Bachmann ◽  
Barbara Krug ◽  
Martin Hellmich ◽  
Max Zinser ◽  
...  
Keyword(s):  
Correlation Coefficient ◽  
Breast Density ◽  
Breast Tissue ◽  
Mathematical Function ◽  
Breast Cancer Patients ◽  
Tissue Weight ◽  
Implant Selection ◽  
Volume Measurements ◽  
The Individual ◽  
The Ideal

Abstract Background The current methods for calculating the ideal implant volume for breast reconstruction are based on pre- or intraoperative volume measurements of the existing breast volume and do not take into account the individual breast density of the woman. This study aims is to identify objective parameters that can help to improve the optimal implant selection. Materials and methods This retrospective analysis includes 198 breast cancer patients who underwent mastectomy. Breast densities (ACR) measured in mammography and MRI were compared with the removed breast tissue weight and volume of the implants used. In addition, the resected weight was compared directly with the implant volume to calculate a mathematical function. Results There was no significant correlation between the ACR values and the resected weights [correlation coefficient: mammography:− 0.117 (p = 0.176), MRI − 0.033 (p = 0.756)]. A negative correlation between the implant volumes and both imaging methods could be demonstrated [correlation coefficient: mammography − 0.268; p = 0.002; MRI was − 0.200 (p = 0.055)]. A highly significant correlation between the resected weights and the implant volumes (correlation coefficient 0.744; p < 0.001) was observed. This correlation corresponds to a power function (y = 34.71 x0.39), in which any resected weight can be used for the variable x to calculate the implant volume. Conclusion We were able to show that there is a significant correlation between the resected breast tissue and the implant volume. With our novel potency function, the appropriate implant volume can be calculated for any resected weight making it easier for the surgeon to choose a fitting implant in a simple and more objective manner.

scholarly journals Postmenopausal Dense Breasts Maintain Premenopausal Levels of GH and Insulin-like Growth Factor Binding Proteins in Vivo

2020 ◽  
Vol 105 (5) ◽  
pp. 1617-1628 ◽  
Author(s):  
Nina Dabrosin ◽  
Charlotta Dabrosin
Keyword(s):  
Postmenopausal Women ◽  
Breast Density ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Dense Breast ◽  
Breast Cancers ◽  
Dense Breast Tissue ◽  
Dense Breasts

Abstract Context Dense breast tissue is associated with 4 to 6 times higher risk of breast cancer by poorly understood mechanisms. No preventive therapy for this high-risk group is available. After menopause, breast density decreases due to involution of the mammary gland. In dense breast tissue, this process is haltered by undetermined biological actions. Growth hormone (GH) and insulin-like binding proteins (IGFBPs) play major roles in normal mammary gland development, but their roles in maintaining breast density are unknown. Objective To reveal in vivo levels of GH, IGFBPs, and other pro-tumorigenic proteins in the extracellular microenvironment in breast cancer, in normal breast tissue with various breast density in postmenopausal women, and premenopausal breasts. We also sought to determine possible correlations between these determinants. Setting and Design Microdialysis was used to collect extracellular in vivo proteins intratumorally from breast cancers before surgery and from normal human breast tissue from premenopausal women and postmenopausal women with mammographic dense or nondense breasts. Results Estrogen receptor positive breast cancers exhibited increased extracellular GH (P &lt; .01). Dense breasts of postmenopausal women exhibited similar levels of GH as premenopausal breasts and significantly higher levels than in nondense breasts (P &lt; .001). Similar results were found for IGFBP-1, -2, -3, and -7 (P &lt; .01) and for IGFBP-6 (P &lt;.05). Strong positive correlations were revealed between GH and IGFBPs and pro-tumorigenic matrix metalloproteinases, urokinase-type plasminogen activator, Interleukin 6, Interleukin 8, and vascular endothelial growth factor in normal breast tissue. Conclusions GH pathways may be targetable for cancer prevention therapeutics in postmenopausal women with dense breast tissue.

scholarly journals Early-life and adult adiposity, adult height, and benign breast tissue composition

2020 ◽  
pp. cebp.1348.2020
Author(s):  
Hannah Oh ◽  
Lusine Yaghjyan ◽  
Rebecca J Austin-Datta ◽  
Yujing J Heng ◽  
Gabrielle M Baker ◽  
...  
Keyword(s):  
Early Life ◽  
Breast Tissue ◽  
Adult Height ◽  
Tissue Composition ◽  
Benign Breast Tissue

scholarly journals Reliability of Automated Breast Density Measurements

Radiology ◽  
2015 ◽  
Vol 275 (2) ◽  
pp. 366-376 ◽  
Author(s):  
Olivier Alonzo-Proulx ◽  
Gordon E. Mawdsley ◽  
James T. Patrie ◽  
Martin J. Yaffe ◽  
Jennifer A. Harvey
Keyword(s):  
Breast Density ◽  
Density Measurements
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