Longitudinal assessment of subsurface artificial root caries lesions by optical coherence tomography in comparison with transverse microradiography

2012 ◽  
Author(s):  
Alireza Sadr ◽  
Syozi Nakashima ◽  
Yasushi Shimada ◽  
Junji Tagami ◽  
Yasunori Sumi
Keyword(s):  
Optical Coherence Tomography ◽  
Root Caries ◽  
Optical Coherence ◽  
Longitudinal Assessment ◽  
Caries Lesions

scholarly journals Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anita S. Y. Chan ◽  
Tin Aung Tun ◽  
John C. Allen ◽  
Myoe Naing Lynn ◽  
Sai Bo Bo Tun ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Ocular Hypertension ◽  
Optic Nerve Head ◽  
Structural Damage ◽  
Structural Changes ◽  
Lamina Cribrosa ◽  
Optical Coherence ◽  
Longitudinal Assessment ◽  
The Mean

Abstract In humans, the longitudinal characterisation of early optic nerve head (ONH) damage in ocular hypertension (OHT) is difficult as patients with glaucoma usually have structural ONH damage at the time of diagnosis. Previous studies assessed glaucomatous ONH cupping by measuring the anterior lamina cribrosa depth (LCD) and minimal rim width (MRW) using optical coherence tomography (OCT). In this study, we induced OHT by repeated intracameral microbead injections in 16 cynomolgus primates (10 unilateral; 6 bilateral) and assessed the structural changes of the ONH longitudinally to observe early changes. Elevated intraocular pressure (IOP) in OHT eyes was maintained for 7 months and serial OCT measurements were performed during this period. The mean IOP was significantly elevated in OHT eyes when compared to baseline and compared to the control eyes. Thinner MRW and deeper LCD values from baseline were observed in OHT eyes with the greatest changes seen between month 1 and month 2 of OHT. Both the mean and maximum IOP values were significant predictors of MRW and LCD changes, although the maximum IOP was a slightly better predictor. We believe that this model could be useful to study IOP-induced early ONH structural damage which is important for understanding glaucoma pathogenesis.

scholarly journals En-Face Optical Coherence Tomography Angiography for Longitudinal Monitoring of Retinal Injury

2019 ◽  
Vol 9 (13) ◽  
pp. 2617
Author(s):  
Jonathan Luisi ◽  
Wei Liu ◽  
Wenbo Zhang ◽  
Massoud Motamedi
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Chronic Phase ◽  
Growth Dynamics ◽  
Tissue Remodeling ◽  
Early Response ◽  
Acute Injury ◽  
Optical Coherence ◽  
Longitudinal Assessment ◽  
En Face

A customized Optical Coherence Tomography Angiography (OCTA) algorithm and Orthogonal OCT (en-face and B-Scans) were used for longitudinal assessment of retina murine vascular and tissue remodeling comparing photoreceptor ablation and laser-induced Choroidal Neovascularization (CNV). In the mouse model, we utilized a combined OCTA/OCT technique to image and quantify morphological and vascular features of laser lesions over time. This approach enabled us to monitor and correlate the dynamics of retina vascular and tissue remodeling as evidenced by swelling, edema, and scarring. From the OCT B-Scans, three stages of inflammatory progression were identified: the early response occurring within hours to day 3, the transition phase from 3–7 days, and the late stage of 7–21 days entering either the resolving phase or chronic phase, respectively. For the case of CNV, en-face OCTA revealed a transient non-perfusion of inner retina capillaries, specifically Deep Vascular Plexus (DVP), which corresponded to growth in lesions of a height of 200 µm or greater. Non-perfusion first occurred at 24 hours, persisted during edema and CNV formation days 7–14. In contrast, the acute inflammation induced photoreceptor damage, but no detectable alterations to the microvasculature were observed. We demonstrated that the en-face OCTA system is capable of visualizing capillary networks (∼5 µm) and the corresponding tissue remodeling and growth dynamics allowing for separating acute injury from CNV. For the first time, by using OCTA we observed the presence of the 5–10 μm capillary non-perfusion present in DVP as part of CNV formation and the associated wound healing in the retina.

scholarly journals Estimation of lesion progress in artificial root caries by swept source optical coherence tomography in comparison to transverse microradiography

2011 ◽  
Vol 16 (7) ◽  
pp. 071408 ◽  
Author(s):  
Yuko Natsume ◽  
Syozi Nakashima ◽  
Alireza Sadr ◽  
Yasushi Shimada ◽  
Junji Tagami ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Root Caries ◽  
Optical Coherence ◽  
Swept Source

scholarly journals Remineralization of root caries monitored using cross polarization optical coherence tomography

2012 ◽  
Author(s):  
Cynthia L. Darling ◽  
Michal Staninec ◽  
Kenneth H. Chan ◽  
Hobin Kang ◽  
Daniel Fried
Keyword(s):  
Optical Coherence Tomography ◽  
Root Caries ◽  
Optical Coherence ◽  
Cross Polarization

scholarly journals Longitudinal Assessment of Alkali Injury on Mouse Cornea Using Anterior Segment Optical Coherence Tomography

2021 ◽  
Vol 10 (3) ◽  
pp. 6
Author(s):  
Jonathan Luisi ◽  
Edward R. Kraft ◽  
Steven A. Giannos ◽  
Krishna Patel ◽  
Mary E. Schmitz-Brown ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Longitudinal Assessment ◽  
Alkali Injury
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