Wavelet-based analysis of gastric microcirculation in rats with ulcer bleedings

2012 ◽  
Author(s):  
A. N. Pavlov ◽  
M. A. Rodionov ◽  
O. N. Pavlova ◽  
O. V. Semyachkina-Glushkovskaya ◽  
V. A. Berdnikova ◽  
...  
Keyword(s):  
Gastric Microcirculation

scholarly journals Photodynamic diagnostics of early gastric cancer: Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach

2019 ◽  
Vol 12 (02) ◽  
pp. 1950007 ◽  
Author(s):  
Alexey Pavlov ◽  
Ekaterina Borisova ◽  
Olga Pavlova ◽  
Ilana Agranovich ◽  
Alexander Khorovodov ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
False Positive ◽  
Aminolevulinic Acid ◽  
Gastric Tumor ◽  
Fluctuation Analysis ◽  
Processed Meat ◽  
Metastatic Adenocarcinoma ◽  
Complexity Measures ◽  
Gastric Microcirculation

The detection of early gastric cancer that often develops asymptomatically is crucial for improving patient survival. The photodynamic diagnosis (PDD) of gastric cancer using 5-aminolevulinic acid/protoporphyrin IX (5-ALA/PpIX) has been reported in several studies. However, the selectivity of PDD of gastric tumor is poor with often false-positive results that require the development of new methods to improve PDD for early gastric cancer. Therefore, a measure of the complexity of gastric microcirculation (multi-scale entropy, MSE) and the detrended fluctuation analysis (DFA) were applied as additional tools to detect early gastric cancer in rats.In this experimental study, we used our original model of metastatic adenocarcinoma in the stomach of a rat. To induce a gastric tumor, we used a long-term combination (for 9 months, which is 1/2 of the life of rats) of two natural factors, such as chronic stress (overpopulation being typical for modern cities) and the daily presence of nitrites in food and drinks, which are common ingredients added to processed meat and fish to help preserve food. Our results clearly show that both methods, namely, PDD using 5-ALA/PpIX and complexity/correlation analysis, can detect early gastric cancer, which was confirmed by histological analysis. Pre-cancerous areas in the stomach were detected as an intermediate fluorescent signal or MSE level between normal and malignant lesions of the stomach. However, in some cases, PDD with 5-ALA/PpIX produced a false-positive fluorescence of exogenous fluorophores due to its accumulation in benign and inflammatory areas of the mucosa. This fact indicates that the PDD itself is not sufficient for the correct diagnosis of gastric cancer, and the use of additional characteristics, e.g., complexity measures or scaling exponents, can significantly improve the diagnostic accuracy of PDD of gastric cancer that should be confirmed in further clinical studies and applications.

Morphology of Gastric Microcirculation in Cirrhosis

Hepatology ◽  
2007 ◽  
Vol 3 (6) ◽  
pp. 1008-1012 ◽  
Author(s):  
Makoto Hashizume ◽  
Kenzo Tanaka ◽  
Kiyoshi Inokuchi
Keyword(s):  
Gastric Microcirculation

scholarly journals Histamine receptors in the gastric microcirculation.

Gut ◽  
1978 ◽  
Vol 19 (11) ◽  
pp. 1059-1063 ◽  
Author(s):  
P H Guth ◽  
E Smith
Keyword(s):  
Histamine Receptors ◽  
Gastric Microcirculation

Escape from vasoconstriction in the gastric microcirculation

1975 ◽  
Vol 228 (6) ◽  
pp. 1893-1895 ◽  
Author(s):  
Paul H. Guth ◽  
Esther Smith
Keyword(s):  
Nerve Stimulation ◽  
Splanchnic Nerve ◽  
System Response ◽  
In Vivo Microscopy ◽  
Adrenergic Stimulation ◽  
Resistance Vessels ◽  
Autoregulatory Escape ◽  
Splanchnic Nerve Stimulation ◽  
Gastric Microcirculation

Escape of splanchnic resistance vessels from vasoconstriction due to adrenergic stimulation has been attributed to increasing submucosal blood flow due to dilation of submucosal arteriovenous anastomoses (shunts). This postulate, as applied to the rat gastric microcirculation, was studied by in vivo microscopy. Using an image-splitting TV microscope recording system, response of gastric submucosal arterioles (13–33 µm) to 3 min of left splanchnic nerve stimulation, norepinephrine superfusion, and vasopressin superfusion was measured. All stimuli produced initial vasoconstriction. Escape occurred in all rats with nerve stimulation and norepinephrine, but in only one of five with vasopressin. No shunts were seen. The study demonstrates that the gastric submucosal arterioles exhibit an escape phenomenon, suggesting that "autoregulatory escape" in other splanchnic beds also may be due to relaxation of constricted vessels and not to opening of shunts.

Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis

1995 ◽  
Vol 108 (4) ◽  
pp. 1183-1191 ◽  
Author(s):  
JoséGeraldo P. Ferraz ◽  
Webb McKnight ◽  
Keith A. Sharkey ◽  
John L. Wallace
Keyword(s):  
Biliary Cirrhosis ◽  
Anesthetized Rats ◽  
Secondary Biliary Cirrhosis ◽  
Gastric Microcirculation

The Effects of Acetazolamide and of Ethoxzolamide on Gastric Microcirculation in Rats (Histochemical Study)

1984 ◽  
Vol 429 (1 Biology and C) ◽  
pp. 601-603 ◽  
Author(s):  
FEDORA BARBARINO ◽  
ELVIRA TOGANEL ◽  
CORNELIA BRILINSCHI
Keyword(s):  
Histochemical Study ◽  
Gastric Microcirculation

Vasoactive agents and the gastric microcirculation

1974 ◽  
Vol 8 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Paul H. Guth ◽  
Esther Smith
Keyword(s):  
Vasoactive Agents ◽  
Gastric Microcirculation
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