scholarly journals Characterization of tissue optical properties for prostate PDT using interstitial diffuse optical tomography

2012 ◽  
Author(s):  
Xing Liang ◽  
Ken Kang-hsin Wang ◽  
Timothy C. Zhu
Keyword(s):  
Optical Properties ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Tissue Optical Properties

Characterization of Metabolic Pathways in Breast Cancer using Diffuse Optical Tomography

2014 ◽  
Author(s):  
So Hyun Chung ◽  
Michael D. Feldman ◽  
Regine Choe ◽  
Daniel Martinez ◽  
Helen Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metabolic Pathways ◽  
Optical Tomography ◽  
Diffuse Optical Tomography

scholarly journals Region-based diffuse optical tomography with registered atlas: in vivo acquisition of mouse optical properties

2016 ◽  
Vol 7 (12) ◽  
pp. 5066 ◽  
Author(s):  
Wenbo Wan ◽  
Yihan Wang ◽  
Jin Qi ◽  
Lingling Liu ◽  
Wenjuan Ma ◽  
...  
Keyword(s):  
Optical Properties ◽  
Optical Tomography ◽  
Diffuse Optical Tomography

scholarly journals A Hybrid Inversion Scheme Combining Markov Chain Monte Carlo and Iterative Methods for Determining Optical Properties of Random Media

2019 ◽  
Vol 9 (17) ◽  
pp. 3500
Author(s):  
Yu Jiang ◽  
Yoko Hoshi ◽  
Manabu Machida ◽  
Gen Nakamura
Keyword(s):  
Monte Carlo ◽  
Optical Properties ◽  
Markov Chain ◽  
Markov Chain Monte Carlo ◽  
Hybrid Method ◽  
Random Media ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Marquardt Algorithm ◽  
Levenberg Marquardt

Near-infrared spectroscopy (NIRS) including diffuse optical tomography is an imaging modality which makes use of diffuse light propagation in random media. When optical properties of a random medium are investigated from boundary measurements of reflected or transmitted light, iterative inversion schemes such as the Levenberg–Marquardt algorithm are known to fail when initial guesses are not close enough to the true value of the coefficient to be reconstructed. In this paper, we investigate how this weakness of iterative schemes is overcome using Markov chain Monte Carlo. Using time-resolved measurements performed against a polyurethane-based phantom, we present a case that the Levenberg–Marquardt algorithm fails to work but the proposed hybrid method works well. Then, with a toy model of diffuse optical tomography we illustrate that the Levenberg–Marquardt method fails when it is trapped by a local minimum but the hybrid method can escape from local minima by using the Metropolis–Hastings Markov chain Monte Carlo algorithm until it reaches the valley of the global minimum. The proposed hybrid scheme can be applied to different inverse problems in NIRS which are solved iteratively. We find that for both numerical and phantom experiments, optical properties such as the absorption and reduced scattering coefficients can be retrieved without being trapped by a local minimum when Monte Carlo simulation is run only about 100 steps before switching to an iterative method. The hybrid method is compared with simulated annealing. Although the Metropolis–Hastings MCMC arrives at the steady state at about 10,000 Monte Carlo steps, in the hybrid method the Monte Carlo simulation can be stopped way before the burn-in time.

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