Multimodal imaging of lung tissue using optical coherence tomography and two photon microscopy

2012 ◽  
Author(s):  
Maria Gaertner ◽  
Peter Cimalla ◽  
Stefan Geissler ◽  
Sven Meissner ◽  
Christian Schnabel ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Lung Tissue ◽  
Multimodal Imaging ◽  
Optical Coherence ◽  
Two Photon Microscopy ◽  
Two Photon

scholarly journals In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy

2015 ◽  
Vol 6 (7) ◽  
pp. 2512 ◽  
Author(s):  
Bumju Kim ◽  
Seung Hun Lee ◽  
Calvin J. Yoon ◽  
Yong Song Gho ◽  
G-One Ahn ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Skin Inflammation ◽  
Optical Coherence ◽  
Two Photon Microscopy ◽  
Two Photon

scholarly journals Combined two-photon microscopy and optical coherence tomography using individually optimized sources

2011 ◽  
Vol 19 (14) ◽  
pp. 13089 ◽  
Author(s):  
Bosu Jeong ◽  
Byunghak Lee ◽  
Min Seong Jang ◽  
Hyoseok Nam ◽  
Sang June Yoon ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Two Photon Microscopy ◽  
Two Photon

scholarly journals Gradient index lens based combined two-photon microscopy and optical coherence tomography

2014 ◽  
Vol 22 (11) ◽  
pp. 12962 ◽  
Author(s):  
Taejun Wang ◽  
Qingyun Li ◽  
Peng Xiao ◽  
Jinhyo Ahn ◽  
Young Eun Kim ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Gradient Index ◽  
Optical Coherence ◽  
Two Photon Microscopy ◽  
Two Photon ◽  
Gradient Index Lens

scholarly journals Intravital imaging of adriamycin-induced renal pathology using two-photon microscopy and optical coherence tomography

2018 ◽  
Vol 11 (05) ◽  
pp. 1850030 ◽  
Author(s):  
Hengchang Guo ◽  
Hsing-Wen Wang ◽  
Qinggong Tang ◽  
Erik Anderson ◽  
Reuben Falola ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Real Time ◽  
Flow Dynamics ◽  
Renal Pathology ◽  
Glomerular Sclerosis ◽  
Deep Penetration ◽  
Optical Coherence ◽  
Two Photon Microscopy ◽  
Two Photon ◽  
Tubular Flow

Adriamycin (doxorubicin), a common cancer chemotherapeutic drug, can be used to induce a model of chronic progressive glomerular disease in rodents. In our studies, we evaluated renal changes in a rat model after Adriamycin injection using two-photon microscopy (TPM), optical coherence tomography (OCT) and Doppler OCT (DOCT). Taking advantage of deep penetration and fast scanning speed for three-dimensional (3D) label-free imaging, OCT/DOCT system was able to reveal glomerular and tubular pathology noninvasively and in real time. By imaging renal pathology following the infusion of fluorophore-labeled dextrans of different molecular weights, TPM can provide direct views of glomerular and tubular flow dynamics with the onset and progression of renal disease. Specifically, glomerular permeability and filtration, proximal and distal tubular flow dynamics can be revealed. 6–8 weeks after injection of Adriamycin, TPM and OCT/DOCT imaging revealed glomerular sclerosis, compromised flow across the glomerular wall, tubular atrophy, tubular dilation, and variable intra-tubular flow dynamics. Our results indicate that TPM and OCT/DOCT provide real-time imaging of renal pathology in vivo that has not been previously available using conventional microscopic procedures.

Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography

2021 ◽  
Vol 320 (4) ◽  
pp. H1370-H1392
Author(s):  
Ádám Nyúl-Tóth ◽  
Stefano Tarantini ◽  
Jordan DelFavero ◽  
Feng Yan ◽  
Priya Balasubramanian ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Optical Coherence ◽  
Two Photon Microscopy ◽  
Two Photon ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Age Related ◽  
Brain Barrier Disruption

Methods are presented for longitudinal detection of age-related increase in blood-brain barrier permeability and microvascular rarefaction in the mouse cerebral cortex by intravital two-photon microscopy and optical coherence tomography.

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