Dual-wavelength endoscopic laser speckle contrast imaging system for indicating tissue blood flow and oxygenation

2012 ◽  
Author(s):  
Lipei Song ◽  
Daniel S. Elson
Keyword(s):  
Blood Flow ◽  
Imaging System ◽  
Laser Speckle ◽  
Dual Wavelength ◽  
Tissue Blood Flow ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Endoscopic Laser

scholarly journals Monitoring blood-flow in the mouse cochlea using an endoscopic laser speckle contrast imaging system

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0191978 ◽  
Author(s):  
Tae Hoon Kong ◽  
Sunkon Yu ◽  
Byungjo Jung ◽  
Jin Sil Choi ◽  
Young Joon Seo
Keyword(s):  
Blood Flow ◽  
Imaging System ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Endoscopic Laser

scholarly journals Transmissive-detected laser speckle contrast imaging for blood flow monitoring in thick tissue: from Monte Carlo simulation to experimental demonstration

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Dong-Yu Li ◽  
Qing Xia ◽  
Ting-Ting Yu ◽  
Jing-Tan Zhu ◽  
Dan Zhu
Keyword(s):  
Monte Carlo Simulation ◽  
Blood Flow ◽  
Monte Carlo ◽  
Laser Speckle ◽  
Tissue Blood Flow ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Imaging Quality ◽  
Speckle Contrast ◽  
Flow Monitoring

AbstractLaser speckle contrast imaging (LSCI) is a powerful tool to monitor blood flow distribution and has been widely used in studies of microcirculation, both for animal and clinical applications. Conventionally, LSCI usually works on reflective-detected mode. However, it could provide promising temporal and spatial resolution for in vivo applications only with the assistance of various tissue windows, otherwise, the overlarge superficial static speckle would extremely limit its contrast and resolution. Here, we systematically investigated the capability of transmissive-detected LSCI (TR-LSCI) for blood flow monitoring in thick tissue. Using Monte Carlo simulation, we theoretically compared the performance of transmissive and reflective detection. It was found that the reflective-detected mode was better when the target layer was at the very surface, but the imaging quality would rapidly decrease with imaging depth, while the transmissive-detected mode could obtain a much stronger signal-to-background ratio (SBR) for thick tissue. We further proved by tissue phantom, animal, and human experiments that in a certain thickness of tissue, TR-LSCI showed remarkably better performance for thick-tissue imaging, and the imaging quality would be further improved if the use of longer wavelengths of near-infrared light. Therefore, both theoretical and experimental results demonstrate that TR-LSCI is capable of obtaining thick-tissue blood flow information and holds great potential in the field of microcirculation research.

scholarly journals Alteration of Blood Flow in a Venular Network by Infusion of Dextran 500: Evaluation with a Laser Speckle Contrast Imaging System

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0140038 ◽  
Author(s):  
Bumseok Namgung ◽  
Yan Cheng Ng ◽  
Jeonghun Nam ◽  
Hwa Liang Leo ◽  
Sangho Kim
Keyword(s):  
Blood Flow ◽  
Imaging System ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast

scholarly journals Dual-Wavelength Laser Speckle Contrast Imaging (dwLSCI) Improves Chronic Measurement of Superficial Blood Flow in Hands

Sensors ◽  
2017 ◽  
Vol 17 (12) ◽  
pp. 2811 ◽  
Author(s):  
Lingke Zhang ◽  
Li Ding ◽  
Miao Li ◽  
Xiaoli Zhang ◽  
Diansan Su ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Speckle ◽  
Dual Wavelength ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Dual Wavelength Laser ◽  
Speckle Contrast

scholarly journals Nephron blood flow dynamics measured by laser speckle contrast imaging

2011 ◽  
Vol 300 (2) ◽  
pp. F319-F329 ◽  
Author(s):  
Niels-Henrik Holstein-Rathlou ◽  
Olga V. Sosnovtseva ◽  
Alexey N. Pavlov ◽  
William A. Cupples ◽  
Charlotte Mehlin Sorensen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Signal Transmission ◽  
Experimental Studies ◽  
Flow Dynamics ◽  
Laser Speckle ◽  
Tubuloglomerular Feedback ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Blood Flow Dynamics

Tubuloglomerular feedback (TGF) has an important role in autoregulation of renal blood flow and glomerular filtration rate (GFR). Because of the characteristics of signal transmission in the feedback loop, the TGF undergoes self-sustained oscillations in single-nephron blood flow, GFR, and tubular pressure and flow. Nephrons interact by exchanging electrical signals conducted electrotonically through cells of the vascular wall, leading to synchronization of the TGF-mediated oscillations. Experimental studies of these interactions have been limited to observations on two or at most three nephrons simultaneously. The interacting nephron fields are likely to be more extensive. We have turned to laser speckle contrast imaging to measure the blood flow dynamics of 50–100 nephrons simultaneously on the renal surface of anesthetized rats. We report the application of this method and describe analytic techniques for extracting the desired data and for examining them for evidence of nephron synchronization. Synchronized TGF oscillations were detected in pairs or triplets of nephrons. The amplitude and the frequency of the oscillations changed with time, as did the patterns of synchronization. Synchronization may take place among nephrons not immediately adjacent on the surface of the kidney.

Enhancing vascular visualization in laser speckle contrast imaging of blood flow using multi-focus image fusion

2018 ◽  
Vol 12 (1) ◽  
pp. e201800100 ◽  
Author(s):  
Wenzhi Lv ◽  
Yang Wang ◽  
Xiao Chen ◽  
Xiaoxi Fu ◽  
Jinling Lu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Image Fusion ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Contrast Imaging ◽  
Speckle Contrast ◽  
Focus Image
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