Fused silica long-term stability: case studies

2011 ◽  
Author(s):  
Maurizio Vannoni ◽  
Andrea Sordini ◽  
Giuseppe Molesini
Keyword(s):  
Case Studies ◽  
Fused Silica ◽  
Term Stability ◽  
Long Term Stability

Long-term stability in end length measures and standard thermal-expansion measures made of various grades of fused silica

1990 ◽  
Vol 33 (4) ◽  
pp. 356-358
Author(s):  
G. A. Pavlova ◽  
E. I. Latysheva ◽  
A. N. Amatuni ◽  
T. A. Kompan ◽  
E. B. Shevchenko
Keyword(s):  
Thermal Expansion ◽  
Fused Silica ◽  
Term Stability ◽  
Long Term Stability

Critical reagent characterization and re-evaluation to ensure long-term stability: two case studies

Bioanalysis ◽  
2021 ◽  
Author(s):  
Teresa M Caiazzo ◽  
Christopher M Shea ◽  
Alison P Joyce
Keyword(s):  
Ligand Binding ◽  
Case Studies ◽  
Binding Assay ◽  
Functional Characterization ◽  
Steady Increase ◽  
Ligand Binding Assay ◽  
Term Stability ◽  
Long Term Stability

Characterization of critical reagents can mitigate adverse impact to ligand-binding assay performance. We investigated the conjugation conditions of a bispecific protein to SULFO-TAG NHS-Ester™ ruthenium to resolve a steady increase in ligand-binding assay background signal. Functional and biophysical attributes in stability samples revealed low pH (4.0) conjugation and formulation buffers were key to decrease aggregate formation. We also identified pH-specific (3.0) purification conditions to reduce aggregate levels from 37% to <5% of a mouse IgG3 reagent antibody. These case studies support the utility of biophysical and functional characterization of critical reagents as a proactive approach to maintain long-term stability and provide the basis for our recommendations a risk-based approach to establish re-evaluation intervals for traditional and novel reagents.

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