Nanoparticle detection by microfluidic resistive pulse sensor with optical evidence

2010 ◽  
Author(s):  
Hongpeng Zhang ◽  
Yongxin Song ◽  
Xinxiang Pan ◽  
Yuqing Sun ◽  
Dongqing Li ◽  
...  
Keyword(s):  
Nanoparticle Detection ◽  
Resistive Pulse ◽  
Pulse Sensor ◽  
Optical Evidence

Size-based cell sorting with a resistive pulse sensor and an electromagnetic pump in a microfluidic chip

2014 ◽  
Vol 36 (3) ◽  
pp. 398-404 ◽  
Author(s):  
Yongxin Song ◽  
Mengqi Li ◽  
Xinxiang Pan ◽  
Qi Wang ◽  
Dongqing Li
Keyword(s):  
Microfluidic Chip ◽  
Cell Sorting ◽  
Electromagnetic Pump ◽  
Resistive Pulse ◽  
Pulse Sensor

Detection of Individual Molecules and Ions by Carbon Nanotube-Based Differential Resistive Pulse Sensor

Small ◽  
2018 ◽  
Vol 14 (15) ◽  
pp. 1800013 ◽  
Author(s):  
Ran Peng ◽  
Xiaowu Shirley Tang ◽  
Dongqing Li
Keyword(s):  
Carbon Nanotube ◽  
Resistive Pulse ◽  
Pulse Sensor

scholarly journals A Simple Displacement Aptamer Assay on Resistive Pulse Sensor for Small Molecule Detection

2020 ◽  
Author(s):  
Rhushabh Maugi ◽  
bernadette gamble ◽  
david bunka ◽  
Mark Platt
Keyword(s):  
Small Molecules ◽  
Small Molecule ◽  
Label Free ◽  
Resistive Pulse ◽  
Pulse Sensor ◽  
Label Free Detection ◽  
Ssdna Aptamer ◽  
Aptamer Assay ◽  
Small Molecule Detection ◽  
Surface Changes

A universal aptamer-based sensing strategy is proposed using DNA modified nanocarriers and Resistive Pulse Sensing for the rapid and label free detection of small molecules. The surface of a magnetic nanocarrier was first modified with a ssDNA aka linker which is designed to be partially complimentary in sequence to a ssDNA aptamer. The aptamer and linker form a stable dsDNA complex on the nanocarriers surface. Upon the addition of the target molecule, a conformational change takes place where the aptamer preferentially binds to the target over the linker; causing the aptamer to be released into solution. The RPS measures the change in velocity of the nanocarrier as its surface changes from dsDNA to ssDNA, and its velocity is used as a proxy for the concentration of the target. We illustrate the versatility of the assay by demonstrating the detection of the antibiotic Moxifloxacin, and chemotherapeutics Imatinib and Irinotecan.

scholarly journals A Tunable 3D Printed Microfluidic Resistive Pulse Sensor for the Characterisation of Algae and Microplastics

2020 ◽  
Author(s):  
Mark Platt ◽  
Eugenie Hunsicker ◽  
Marcus Pollard
Keyword(s):  
Additive Manufacturing ◽  
High Throughput ◽  
Low Cost ◽  
Physical Property ◽  
Health Food ◽  
Suspended Particulates ◽  
Resistive Pulse ◽  
Pulse Sensor ◽  
3D Printed ◽  
Rod Structures

Technologies that can detect and characterise particulates in liquids have applications in health, food and environmental monitoring. Here we present a low-cost and high-throughput multiuse counter that classifies a particle’s size, concentration, porosity and shape. Using an additive manufacturing process, we have assembled a reusable flow resistive pulse sensor. The device remains stable for several days with repeat measurements. We demonstrate its use for characterising algae with spherical and rod structures as well as microplastics shed from teabags. We present a methodology that results in a specific signal for microplastics, namely a conductive pulse, in contrast to particles with smooth surfaces such as calibration particles or algae, allowing the presence of microplastics to be easily confirmed and quantified. In addition, the shape of the signal and particle are correlated, giving an extra physical property to characterise suspended particulates. The technology can rapidly screen volumes of liquid, 1 mL/ min, for the presence of microplastics and algae.<br>

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