In vivo investigation of the evolution of skin barrier repair after mechanical injury

2011 ◽  
Author(s):  
Steven Walston ◽  
Melissa Chu ◽  
Inseok Seo ◽  
Paulo R. Bargo ◽  
Nikiforos Kollias
Keyword(s):  
Skin Barrier ◽  
Mechanical Injury ◽  
Barrier Repair ◽  
Skin Barrier Repair

scholarly journals Compromising human skin in vivo and ex vivo to study skin barrier repair

2019 ◽  
Vol 1864 (8) ◽  
pp. 1103-1108 ◽  
Author(s):  
T. Berkers ◽  
W.A. Boiten ◽  
S. Absalah ◽  
J. van Smeden ◽  
A.P.M. Lavrijsen ◽  
...  
Keyword(s):  
Human Skin ◽  
Ex Vivo ◽  
Skin Barrier ◽  
Barrier Repair ◽  
Skin Barrier Repair

scholarly journals Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis

2020 ◽  
Vol 21 (20) ◽  
pp. 7607
Author(s):  
Hai Le Thanh Nguyen ◽  
Juan Valentin Trujillo-Paez ◽  
Yoshie Umehara ◽  
Hainan Yue ◽  
Ge Peng ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Antimicrobial Peptides ◽  
Tight Junction ◽  
Tight Junctions ◽  
Skin Barrier ◽  
Physical Barrier ◽  
Cutaneous Infections ◽  
Barrier Disruption ◽  
Barrier Repair ◽  
Skin Barrier Repair

Atopic dermatitis (AD) is a common chronic inflammatory skin disease that exhibits a complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are susceptible to cutaneous infections that may progress to complications, including staphylococcal septicemia. Although most studies have focused on filaggrin mutations, the physical barrier and antimicrobial barrier also play critical roles in the pathogenesis of AD. Within the physical barrier, the stratum corneum and tight junctions play the most important roles. The tight junction barrier is involved in the pathogenesis of AD, as structural and functional defects in tight junctions not only disrupt the physical barrier but also contribute to immunological impairments. Furthermore, antimicrobial peptides, such as LL-37, human β-defensins, and S100A7, improve tight junction barrier function. Recent studies elucidating the pathogenesis of AD have led to the development of barrier repair therapy for skin barrier defects in patients with this disease. This review analyzes the association between skin barrier disruption in patients with AD and antimicrobial peptides to determine the effect of these peptides on skin barrier repair and to consider employing antimicrobial peptides in barrier repair strategies as an additional approach for AD management.

Non-invasive assessment of tryptophan fluorescence and confocal microscopy provide information on skin barrier repair dynamics beyond TEWL

2012 ◽  
Vol 22 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Paulo R. Bargo ◽  
Steven T. Walston ◽  
Melissa Chu ◽  
Inseok Seo ◽  
Nikiforos Kollias
Keyword(s):  
Confocal Microscopy ◽  
Skin Barrier ◽  
Tryptophan Fluorescence ◽  
Non Invasive ◽  
Barrier Repair ◽  
Skin Barrier Repair

scholarly journals 267 Influence of mouse beta-defensin 14 on skin barrier repair and bacterial growth

2016 ◽  
Vol 136 (9) ◽  
pp. S206
Author(s):  
E. Proksch ◽  
C. Neumann ◽  
J. Harder ◽  
N. Graumann
Keyword(s):  
Bacterial Growth ◽  
Skin Barrier ◽  
Barrier Repair ◽  
Skin Barrier Repair
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