Direct visualization of regions with lowered bone mineral density in dual-energy CT images of vertebrae

2011 ◽  
Author(s):  
Stefan Wesarg ◽  
Marius Erdt ◽  
Konstantinos Kafchitsas ◽  
M. Fawad Khan
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Ct Images ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Direct Visualization ◽  
Mineral Density

Dual-Energy CT–based Phantomless in Vivo Three-dimensional Bone Mineral Density Assessment of the Lumbar Spine

Radiology ◽  
2014 ◽  
Vol 271 (3) ◽  
pp. 778-784 ◽  
Author(s):  
Julian L. Wichmann ◽  
Christian Booz ◽  
Stefan Wesarg ◽  
Konstantinos Kafchitsas ◽  
Ralf W. Bauer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Three Dimensional ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Mineral Density ◽  
Bone Mineral Density Assessment ◽  
Density Assessment

scholarly journals Diagnostic accuracy of quantitative dual-energy CT-based volumetric bone mineral density assessment for the prediction of osteoporosis-associated fractures

2021 ◽  
Author(s):  
Leon D. Gruenewald ◽  
Vitali Koch ◽  
Simon S. Martin ◽  
Ibrahim Yel ◽  
Katrin Eichler ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
At Risk ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Volumetric Bone Mineral Density ◽  
Material Decomposition ◽  
Mineral Density ◽  
Risk Patients

Abstract Objectives To evaluate the predictive value of volumetric bone mineral density (BMD) assessment of the lumbar spine derived from phantomless dual-energy CT (DECT)-based volumetric material decomposition as an indicator for the 2-year occurrence risk of osteoporosis-associated fractures. Methods L1 of 92 patients (46 men, 46 women; mean age, 64 years, range, 19–103 years) who had undergone third-generation dual-source DECT between 01/2016 and 12/2018 was retrospectively analyzed. For phantomless BMD assessment, dedicated DECT postprocessing software using material decomposition was applied. Digital files of all patients were sighted for 2 years following DECT to obtain the incidence of osteoporotic fractures. Receiver operating characteristic (ROC) analysis was used to calculate cut-off values and logistic regression models were used to determine associations of BMD, sex, and age with the occurrence of osteoporotic fractures. Results A DECT-derived BMD cut-off of 93.70 mg/cm3 yielded 85.45% sensitivity and 89.19% specificity for the prediction to sustain one or more osteoporosis-associated fractures within 2 years after BMD measurement. DECT-derived BMD was significantly associated with the occurrence of new fractures (odds ratio of 0.8710, 95% CI, 0.091–0.9375, p < .001), indicating a protective effect of increased DECT-derived BMD values. Overall AUC was 0.9373 (CI, 0.867–0.977, p < .001) for the differentiation of patients who sustained osteoporosis-associated fractures within 2 years of BMD assessment. Conclusions Retrospective DECT-based volumetric BMD assessment can accurately predict the 2-year risk to sustain an osteoporosis-associated fracture in at-risk patients without requiring a calibration phantom. Lower DECT-based BMD values are strongly associated with an increased risk to sustain fragility fractures. Key Points •Dual-energy CT–derived assessment of bone mineral density can identify patients at risk to sustain osteoporosis-associated fractures with a sensitivity of 85.45% and a specificity of 89.19%. •The DECT-derived BMD threshold for identification of at-risk patients lies above the American College of Radiology (ACR) QCT guidelines for the identification of osteoporosis (93.70 mg/cm3 vs 80 mg/cm3).

Quantitative dual-energy CT for phantomless evaluation of cancellous bone mineral density of the vertebral pedicle: correlation with pedicle screw pull-out strength

2014 ◽  
Vol 25 (6) ◽  
pp. 1714-1720 ◽  
Author(s):  
Julian L. Wichmann ◽  
Christian Booz ◽  
Stefan Wesarg ◽  
Ralf W. Bauer ◽  
J. Matthias Kerl ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Pedicle Screw ◽  
Bone Mineral ◽  
Cancellous Bone ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Mineral Density ◽  
Pull Out ◽  
Pull Out Strength

Performance Evaluation of Material Decomposition With Rapid-Kilovoltage-Switching Dual-Energy CT and Implications for Assessing Bone Mineral Density

2015 ◽  
Vol 204 (6) ◽  
pp. 1234-1241 ◽  
Author(s):  
John M. S. Wait ◽  
Dianna Cody ◽  
Aaron K. Jones ◽  
John Rong ◽  
Veerabhadran Baladandayuthapani ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Performance Evaluation ◽  
Bone Mineral ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Material Decomposition ◽  
Mineral Density

scholarly journals POS0045 LEAST SIGNIFICANT CHANGE IN BONE DENSITOMETRY IN PATIENTS WITH OBESITY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 227.2-228
Author(s):  
D. Claire ◽  
M. Geoffroy ◽  
L. Kanagaratnam ◽  
C. Isabelle ◽  
A. Hittinger ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
General Population ◽  
Bone Mineral ◽  
Bone Densitometry ◽  
Dual Energy ◽  
Mineral Density ◽  
Least Significant Change ◽  
X Ray ◽  
Significant Change

Background:Dual energy X-ray absoprtiometry is the reference method to mesure bone mineral density (1). Loss of bone mineral density is significant if it exceeds the least significant change. The threshold value used in general population is 0,03 g/cm2 (2). Patients with obesity are known for having a higher bone mineral density due to metabolism and physiopathology characteristics (3,4).Objectives:The aim of our study was to determine the least significant change in bone densitometry in patients with obesity.Methods:We conducted an interventionnal study in 120 patients with obesity who performed a bone densitometry. We measured twice the bone mineral density at the lumbar spine, the femoral neck and the total hip in the same time (5,6). We determined the least significant change in bone densitometry from each pair of measurements, using the Bland and Altman method. We also determined the least significant change in bone densitometry according to each stage of obesity.Results:The least significant change in bone densitometry in patients with obesity is 0,046g/cm2 at the lumbar spine, 0.069 g/cm2 at the femoral neck and 0.06 g/cm2 at the total hip.Conclusion:The least significant change in bone densitometry in patients with obesity is higher than in general population. These results may improve DXA interpretation in this specific population, and may personnalize their medical care.References:[1]Lees B, Stevenson JC. An evaluation of dual-energy X-ray absorptiometry and comparison with dual-photon absorptiometry. Osteoporos Int. mai 1992;2(3):146-52.[2]Briot K, Roux C, Thomas T, Blain H, Buchon D, Chapurlat R, et al. Actualisation 2018 des recommandations françaises du traitement de l’ostéoporose post-ménopausique. Rev Rhum. oct 2018;85(5):428-40.[3]Shapses SA, Pop LC, Wang Y. Obesity is a concern for bone health with aging. Nutr Res N Y N. mars 2017;39:1-13.[4]Savvidis C, Tournis S, Dede AD. Obesity and bone metabolism. Hormones. juin 2018;17(2):205-17.[5]Roux C, Garnero P, Thomas T, Sabatier J-P, Orcel P, Audran M, et al. Recommendations for monitoring antiresorptive therapies in postmenopausal osteoporosis. Jt Bone Spine Rev Rhum. janv 2005;72(1):26-31.[6]Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C. Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res. août 1999;14(8):1449-56.Disclosure of Interests:None declared.

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