A novel method for eliminating autofluorescence of small animals in fluorescence molecular imaging

2011 ◽  
Author(s):  
Zhenwen Xue ◽  
Jie Tian ◽  
Dong Han ◽  
Xibo Ma
Keyword(s):  
Molecular Imaging ◽  
Small Animals ◽  
Novel Method ◽  
Fluorescence Molecular Imaging

Fluorescence Molecular Imaging of Small Animal Tumor Models

2004 ◽  
Vol 4 (4) ◽  
pp. 419-430 ◽  
Author(s):  
E. Graves ◽  
R. Weissleder ◽  
V. Ntziachristos
Keyword(s):  
Molecular Imaging ◽  
Small Animal ◽  
Tumor Models ◽  
Animal Tumor ◽  
Fluorescence Molecular Imaging

P-161 EGFR-targeted fluorescence molecular imaging for postoperative lymph node assessment in patients with oral cancer

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 17
Author(s):  
J. Vonk ◽  
J.G. deWit ◽  
F.J. Voskuil ◽  
Y.H. Tang ◽  
W.T.R. Hooghiemstra ◽  
...  
Keyword(s):  
Lymph Node ◽  
Molecular Imaging ◽  
Oral Cancer ◽  
Lymph Node Assessment ◽  
Fluorescence Molecular Imaging

Visualization of pulmonary inflammation using noninvasive fluorescence molecular imaging

2008 ◽  
Vol 104 (3) ◽  
pp. 795-802 ◽  
Author(s):  
Jodi Haller ◽  
Damon Hyde ◽  
Nikolaos Deliolanis ◽  
Ruben de Kleine ◽  
Mark Niedre ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Quantitative Imaging ◽  
Pulmonary Inflammation ◽  
Small Animal ◽  
Mouse Lung ◽  
Chronic Obstructive ◽  
Therapy Assessment ◽  
Fluorescence Molecular Imaging

The ability to visualize molecular processes and cellular regulators of complex pulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), or adult respiratory distress syndrome (ARDS), would aid in the diagnosis, differentiation, therapy assessment and in small animal-based drug-discovery processes. Herein we report the application of normalized transillumination and fluorescence molecular tomography (FMT) for the noninvasive quantitative imaging of the mouse lung in vivo. We demonstrate the ability to visualize and quantitate pulmonary response in a murine model of LPS-induced airway inflammation. Twenty-four hours prior to imaging, BALB/c female mice were injected via tail vein with 2 nmol of a cathepsin-sensitive activatable fluorescent probe (excitation: 750 nm; emission: 780 nm) and 2 nmol of accompanying intravascular agent (excitation: 674 nm; emission: 694 nm). Six hours later, the mice were anesthetized with isoflurane and administered intranasal LPS in sterile 0.9% saline in 25 μl aliquots (one per nostril). Fluorescence molecular imaging revealed the in vivo profile of cysteine protease activation and vascular distribution within the lung typifying the inflammatory response to LPS insult. Results were correlated with standard in vitro laboratory tests (Western blot, bronchoalveolar lavage or BAL analysis, immunohistochemistry) and revealed good correlation with the underlying activity. We demonstrated the capacity of fluorescence tomography to noninvasively and longitudinally characterize physiological, cellular, and subcellular processes associated with inflammatory disease burden in the lung. The data presented herein serve to further evince fluorescence molecular imaging as a technology highly appropriate for the biomedical laboratory.

Dual-Modality Molecular Imaging for Small Animals Using Fluorescence and X-Ray Computed Tomography

2009 ◽  
Author(s):  
Yuting Lin ◽  
William C. Barber ◽  
Jan S. Iwanczk ◽  
Einar Nygard ◽  
Nail Malakov ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Molecular Imaging ◽  
Small Animals ◽  
X Ray ◽  
Dual Modality ◽  
X Ray Computed
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