scholarly journals Comparison of iron oxide nanoparticle and microwave hyperthermia alone or combined with cisplatinum in murine breast tumors

2011 ◽  
Author(s):  
Alicia A. Petryk ◽  
Robert V. Stigliano ◽  
Andrew J. Giustini ◽  
Rachel E. Gottesman ◽  
B. S. Trembly ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Breast Tumors ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Microwave Hyperthermia

scholarly journals Imaging breast cancer using a dual-ligand nanochain particle

2018 ◽  
Author(s):  
Gil Covarrubias ◽  
Anthony Cha ◽  
Abdelrahman Rahmy ◽  
Morgan Lorkowski ◽  
Vindya Perera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Iron Oxide ◽  
Linear Chain ◽  
Breast Tumors ◽  
Iron Oxide Nanoparticle ◽  
Vascular Targeting ◽  
Temporal Expression ◽  
Tumor Endothelium ◽  
Oxide Nanoparticle

ABSTRACTNanoparticles often only exploit the upregulation of a receptor on cancer cells to enhance intratumoral deposition of therapeutic and imaging agents. However, a single targeting moiety assumes that a tumor is homogenous and static. Tumoral microenvironments are both heterogenous and dynamic, often displaying variable spatial and temporal expression of targetable receptors throughout disease progression. Here, we evaluated the in vivo performance of an iron oxide nanoparticle in terms of targeting and imaging of orthotropic mouse models of aggressive breast tumors. The nanoparticle, a multi-component nanochain, was comprised of 3-5 iron oxide nanoparticles chemically linked in a linear chain. The nanoparticle’s surface was decorated with two types of ligands each targeting two different upregulated biomarkers on the tumor endothelium, P-selectin and fibronectin. The nanochain exhibited improved tumor deposition not only through vascular targeting but also through its elongated structure. A single-ligand nanochain exhibited a ∼2.5-fold higher intratumoral deposition than a spherical nanoparticle variant. Furthermore, the dual-ligand nanochain exhibited higher consistency in generating detectable MR signals compared to a single-ligand nanochain. Using a 7T MRI, the dual-ligand nanochains exhibited highly detectable MR signal within 3h after injection in two different animal models of breast cancer.

scholarly journals Reversible magnetism switching of iron oxide nanoparticle dispersions by controlled agglomeration

2021 ◽  
Author(s):  
Stephan Müssig ◽  
Björn Kuttich ◽  
Florian Fidler ◽  
Daniel Haddad ◽  
Susanne Wintzheimer ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Light Scattering ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
X Ray ◽  
X Ray Scattering ◽  
Nanoparticle Dispersions ◽  
Oxide Nanoparticle

The controlled agglomeration of superparamagnetic iron oxide nanoparticles (SPIONs) was used to rapidly switch their magnetic properties. Small-angle X-ray scattering (SAXS) and dynamic light scattering showed that tailored iron oxide...

Iron Oxide Nanoparticle Coatings Dictate Cell Outcomes Despite the Influence of Protein Coronas

2021 ◽  
Vol 13 (7) ◽  
pp. 7924-7944
Author(s):  
Yadileiny Portilla ◽  
Sara Mellid ◽  
Alberto Paradela ◽  
Antonio Ramos-Fernández ◽  
Neus Daviu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Nanoparticle Coatings

Succinylated heparin monolayer coating vastly increases superparamagnetic iron oxide nanoparticle T2 proton relaxivity

Nanoscale ◽  
2019 ◽  
Vol 11 (27) ◽  
pp. 12905-12914 ◽  
Author(s):  
Manman Xie ◽  
Shijia Liu ◽  
Christopher J. Butch ◽  
Shaowei Liu ◽  
Ziyang Wang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Clinical Use ◽  
History Of ◽  
Oxide Nanoparticle ◽  
Superparamagnetic Iron Oxide Nanoparticle

Superparamagnetic iron oxide nanoparticles (SPIONs) have a history of clinical use as contrast agents in T2 weighted MRI, though relatively low T2 relaxivity has caused them to fall out of favor as new faster MRI techniques have gained prominence.

scholarly journals Dextran-coated iron oxide nanoparticle-induced nanotoxicity in neuron cultures

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ryan P. Badman ◽  
Shanna L. Moore ◽  
Jessica L. Killian ◽  
Tuancheng Feng ◽  
Thomas A. Cleland ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle

scholarly journals Polymer/Iron Oxide Nanoparticle Composites—A Straight Forward and Scalable Synthesis Approach

2015 ◽  
Vol 16 (8) ◽  
pp. 19752-19768 ◽  
Author(s):  
Jens Sommertune ◽  
Abhilash Sugunan ◽  
Anwar Ahniyaz ◽  
Rebecca Bejhed ◽  
Anna Sarwe ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Scalable Synthesis ◽  
Nanoparticle Composites ◽  
Synthesis Approach

Activatable molecular MRI nanoprobe for tumor cell imaging based on gadolinium oxide and iron oxide nanoparticle

2016 ◽  
Vol 86 ◽  
pp. 1047-1053 ◽  
Author(s):  
Jingjing Li ◽  
Shan Wang ◽  
Chen Wu ◽  
Yue Dai ◽  
Pingfu Hou ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Tumor Cell ◽  
Cell Imaging ◽  
Gadolinium Oxide ◽  
Iron Oxide Nanoparticle ◽  
Molecular Mri ◽  
Oxide Nanoparticle

Predictable Heating and Positive MRI Contrast from a Mesoporous Silica-Coated Iron Oxide Nanoparticle

2016 ◽  
Vol 13 (7) ◽  
pp. 2172-2183 ◽  
Author(s):  
Katie R. Hurley ◽  
Hattie L. Ring ◽  
Michael Etheridge ◽  
Jinjin Zhang ◽  
Zhe Gao ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Iron Oxide Nanoparticle ◽  
Mri Contrast ◽  
Oxide Nanoparticle

scholarly journals Comparative iron oxide nanoparticle cellular dosimetry and response in mice by the inhalation and liquid cell culture exposure routes

2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Justin G Teeguarden ◽  
Vladimir B Mikheev ◽  
Kevin R Minard ◽  
William C Forsythe ◽  
Wei Wang ◽  
...  
Keyword(s):  
Cell Culture ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Liquid Cell ◽  
Oxide Nanoparticle ◽  
Cellular Dosimetry ◽  
Exposure Routes
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