Time-domain diffuse optical spectroscopy up to 1700 nm using an InGaAs/InP single-photon avalanche diode

2011 ◽  
Author(s):  
Ilaria Bargigia ◽  
Alberto Tosi ◽  
Andrea Farina ◽  
Andrea Bassi ◽  
Paola Taroni ◽  
...  
Keyword(s):  
Optical Spectroscopy ◽  
Time Domain ◽  
Single Photon ◽  
Diffuse Optical Spectroscopy ◽  
Avalanche Diode

scholarly journals Time-Resolved Diffuse Optical Spectroscopy up to 1700 nm by Means of a Time-Gated InGaAs/InP Single-Photon Avalanche Diode

2012 ◽  
Vol 66 (8) ◽  
pp. 944-950 ◽  
Author(s):  
Ilaria Bargigia ◽  
Alberto Tosi ◽  
Andrea Bahgat Shehata ◽  
Adriano Della Frera ◽  
Andrea Farina ◽  
...  
Keyword(s):  
Optical Spectroscopy ◽  
Single Photon ◽  
Time Resolved ◽  
Diffuse Optical Spectroscopy ◽  
Avalanche Diode

scholarly journals Special Issue on New Horizons in Time Domain Diffuse Optical Spectroscopy and Imaging

2020 ◽  
Vol 10 (8) ◽  
pp. 2752
Author(s):  
Yoko Hoshi
Keyword(s):  
Infrared Spectroscopy ◽  
Optical Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Time Domain ◽  
Near Infrared ◽  
Special Issue ◽  
Diffuse Optical Spectroscopy ◽  
New Horizons

In 1977, Jöbsis first described the in vivo application of near-infrared spectroscopy (NIRS) [...]

scholarly journals Non-invasive investigation of adipose tissue by time domain diffuse optical spectroscopy

2020 ◽  
Vol 11 (5) ◽  
pp. 2779
Author(s):  
Pranav Lanka ◽  
Agnese Segala ◽  
Andrea Farina ◽  
Sanathana Konugolu Venkata Sekar ◽  
Enzo Nisoli ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Optical Spectroscopy ◽  
Time Domain ◽  
Diffuse Optical Spectroscopy ◽  
Non Invasive

Time-domain diffuse optical spectroscopy beyond 1100 nm: initial feasibility study

2011 ◽  
Author(s):  
Antonio Pifferi ◽  
Ilaria Bargigia ◽  
Paola Taroni ◽  
Andrea Farina ◽  
Rinaldo Cubeddu
Keyword(s):  
Optical Spectroscopy ◽  
Feasibility Study ◽  
Time Domain ◽  
Diffuse Optical Spectroscopy

Time-domain diffuse optical spectroscopy beyond 1100 nm:initial feasibility study

2011 ◽  
Author(s):  
Antonio Pifferi ◽  
Ilaria Bargigia ◽  
Paola Taroni ◽  
Andrea Farina ◽  
Rinaldo Cubeddua
Keyword(s):  
Optical Spectroscopy ◽  
Feasibility Study ◽  
Time Domain ◽  
Diffuse Optical Spectroscopy

scholarly journals Characterization of a Time-Resolved Diffuse Optical Spectroscopy Prototype Using Low-Cost, Compact Single Photon Avalanche Detectors for Tissue Optics Applications

Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 3680 ◽  
Author(s):  
Mrwan Alayed ◽  
Darek Palubiak ◽  
M. Deen
Keyword(s):  
Optical Properties ◽  
Optical Spectroscopy ◽  
Single Photon ◽  
Low Cost ◽  
Oxide Semiconductor ◽  
Tissue Optics ◽  
Time Resolved ◽  
Instrument Response Function ◽  
Diffuse Optical Spectroscopy ◽  
Compact Size

Time-resolved diffuse optical spectroscopy (TR-DOS) is an increasingly used method to determine the optical properties of diffusive media, particularly for medical applications including functional brain, breast and muscle measurements. For medical imaging applications, important features of new generation TR-DOS systems are low-cost, small size and efficient inverse modeling. To address the issues of low-cost, compact size and high integration capabilities, we have developed free-running (FR) single-photon avalanche diodes (SPADs) using 130 nm silicon complementary metal-oxide-semiconductor (CMOS) technology and used it in a TR-DOS prototype. This prototype was validated using assessments from two known protocols for evaluating TR-DOS systems for tissue optics applications. Following the basic instrumental performance protocol, our prototype had sub-nanosecond total instrument response function and low differential non-linearity of a few percent. Also, using light with optical power lower than the maximum permissible exposure for human skin, this prototype can acquire raw data in reflectance geometry for phantoms with optical properties similar to human tissues. Following the MEDPHOT protocol, the absolute values of the optical properties for several homogeneous phantoms were retrieved with good accuracy and linearity using a best-fitting model based on the Levenberg-Marquardt method. Overall, the results of this study show that our silicon CMOS-based SPAD detectors can be used to build a multichannel TR-DOS prototype. Also, real-time functional monitoring of human tissue such as muscles, breasts and newborn heads will be possible by integrating this detector with a time-to-digital converter (TDC).

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