Label-free in vivo optical micro-angiography imaging of cerebral capillary blood flow within meninges and cortex in mice with the skull left intact

2011 ◽  
Author(s):  
Yali Jia ◽  
Ruikang K. Wang
Keyword(s):  
Blood Flow ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Label Free ◽  
Cerebral Capillary

Acute pancreatitis in rats: effects of sodium taurocholate, CCK-8, and Sec on pancreatic microcirculation

1997 ◽  
Vol 272 (2) ◽  
pp. G310-G320 ◽  
Author(s):  
T. Plusczyk ◽  
S. Westermann ◽  
D. Rathgeb ◽  
G. Feifel
Keyword(s):  
Blood Flow ◽  
Pancreatic Duct ◽  
Capillary Permeability ◽  
Sodium Taurocholate ◽  
Capillary Density ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Biliary Pancreatitis ◽  
Acute Biliary Pancreatitis

With use of in vivo microscopy, pancreatic duct permeability, red blood cell (RBC) velocities, functional capillary density (FCD), and overall changes in capillary blood flow (perfusion index) were estimated after intraductal infusion of sodium taurocholate (0.8 ml, 4%) alone or in combination with systemic administration of cholecystokinin (CCK, 0.3 microg/100 g body wt) or secretin (Sec, 10 microg/100 g body wt). Sodium taurocholate mediated a significant increase in pancreatic duct and capillary permeability within 105 +/- 26 s followed by a transient decrease in RBC velocities and a sustained decrease in FCD, which were paralleled by dramatic flow heterogeneity. Therefore, a significant reduction in overall capillary blood flow was calculated. CCK stimulation aggravated the microcirculatory failure due to a decrease in RBC velocities, which was accompanied by an increase in acinar cellular necrosis. Sec stimulation attenuated microcirculatory failure due to a more moderate reduction of FCD. The enhanced pancreatic duct and capillary permeability, which enables free diffusion of pancreatic digestive enzymes into the parenchyma, is the initiating event in acute biliary pancreatitis, causing microcirculatory failure and tissue damage. The microcirculatory changes are secondary and a propagating factor for the development of acini necrosis. Stimulation with CCK worsened the course of acute biliary pancreatitis.

Microscopic Dynamics of Cerebral Capillary Blood Flow in Aged Anesthetized Rats

2014 ◽  
Author(s):  
Michèle Desjardins ◽  
Romain Berti ◽  
Joël Lefebvre ◽  
Simon Dubeau ◽  
Frédéric Lesage
Keyword(s):  
Blood Flow ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Anesthetized Rats ◽  
Cerebral Capillary ◽  
Microscopic Dynamics

In Vivo Fluorescence Microscopy of Microcirculation in the Renal Cortex of Mice

1993 ◽  
Vol 34 (2) ◽  
pp. 168-173 ◽  
Author(s):  
B. Högström ◽  
P. Rooth ◽  
O. Sunnegårdh ◽  
S.-O. Hietala
Keyword(s):  
Blood Flow ◽  
Fluorescence Microscopy ◽  
Experimental Model ◽  
Rating Scale ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
Cortical Blood Flow ◽  
In Vivo Fluorescence ◽  
Renal Cortical Blood Flow

An experimental model using in vivo fluorescence microscopy for studies of renal cortical blood flow was tested in 40 mice. The model was suitable for testing a wide variety of hypotheses concerning alterations in renal cortical blood flow, including the possibility of inhomogeneous capillary blood flow distribution in response to i.v. infusions. The experimental model was tested for the effects of i.v. infusion of mannitol (0.3 mol/l). Effects of anesthesia and mechanical kidney fixation on renal cortical blood flow were studied. Neuroleptic analgesia was less hazardous to the animals than pentobarbital. Due to artifacts from respiratory and peristaltic motion, it was not possible to use neuroleptic analgesia without mechanical kidney fixation. A rating scale was designed for evaluating the capillary blood flow. The correlation between repeated ratings by the same observer was 0.806 and between 2 different observers 0.59.

scholarly journals Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors

Cell Reports ◽  
2021 ◽  
Vol 36 (7) ◽  
pp. 109558
Author(s):  
Chia-Jung Tsai ◽  
Takeshi Nagata ◽  
Chih-Yao Liu ◽  
Takaya Suganuma ◽  
Takeshi Kanda ◽  
...  
Keyword(s):  
Blood Flow ◽  
Rem Sleep ◽  
Capillary Blood ◽  
Capillary Blood Flow ◽  
A2a Receptors ◽  
Cerebral Capillary
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