Evaluation of liver function using gadoxetate disodium (Gd-EOB-DTPA) enhanced MR imaging

2010 ◽  
Author(s):  
Akira Yamada ◽  
Takeshi Hara ◽  
Feng Li ◽  
Kunio Doi
Keyword(s):  
Liver Function ◽  
Mr Imaging ◽  
Gadoxetate Disodium

scholarly journals Quantitative Evaluation of Liver Function with Use of Gadoxetate Disodium–enhanced MR Imaging

Radiology ◽  
2011 ◽  
Vol 260 (3) ◽  
pp. 727-733 ◽  
Author(s):  
Akira Yamada ◽  
Takeshi Hara ◽  
Feng Li ◽  
Yasunari Fujinaga ◽  
Kazuhiko Ueda ◽  
...  
Keyword(s):  
Liver Function ◽  
Mr Imaging ◽  
Quantitative Evaluation ◽  
Gadoxetate Disodium

MR imaging of renal collecting system with gadoxetate disodium: Feasibility for MR urography

2013 ◽  
Vol 38 (4) ◽  
pp. 816-823 ◽  
Author(s):  
R. Joshua Dym ◽  
Victoria Chernyak ◽  
Alla M. Rozenblit
Keyword(s):  
Mr Imaging ◽  
Gadoxetate Disodium ◽  
Mr Urography ◽  
Collecting System

Hepatic hemangiomas: Difference in enhancement pattern on 3T MR imaging with gadobenate dimeglumine versus gadoxetate disodium

2012 ◽  
Vol 81 (10) ◽  
pp. 2457-2462 ◽  
Author(s):  
Rajan T. Gupta ◽  
Daniele Marin ◽  
Daniel T. Boll ◽  
Daniela B. Husarik ◽  
Drew E. Davis ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Gadobenate Dimeglumine ◽  
Gadoxetate Disodium ◽  
Enhancement Pattern ◽  
Hepatic Hemangiomas ◽  
3T Mr

scholarly journals Intracellular accumulation capacity of gadoxetate: initial results for a novel biomarker of liver function

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ute Lina Fahlenkamp ◽  
Katharina Ziegeler ◽  
Lisa Christine Adams ◽  
Sarah Maria Böker ◽  
Günther Engel ◽  
...  
Keyword(s):  
Liver Function ◽  
Extracellular Volume ◽  
Reduction Rate ◽  
Hepatobiliary Phase ◽  
Gadoxetate Disodium ◽  
Intracellular Accumulation ◽  
Accumulation Capacity ◽  
Contrast Agent Administration ◽  
Function Correlation ◽  
Scientific Value

Abstract Previous studies have shown gadoxetate disodium’s potential to represent liver function by its retention in the hepatobiliary phase. Additionally, in cardiac imaging, quantitative characterization of altered parenchyma is established by extracellular volume (ECV) calculation with extracellular contrast agents. Therefore, the purpose of our study was to evaluate whether intracellular accumulation capacity (IAC) of gadoxetate disodium derived from ECV calculation provides added scientific value in terms of liver function compared to the established parameter reduction rate (RR). After local review board approval, 105 patients undergoing standard MR examination with gadoxetate disodium were included. Modified Look-Locker sequences were obtained before and 20 min after contrast agent administration. RR and IAC were calculated and correlated with serum albumin, as a marker of synthetic liver function. Correlation was higher between IAC and albumin, than between RR and albumin. Additionally, capacity of both RR and IAC to distinguish between patients with or without liver cirrhosis was investigated, and differed significantly in their respective means between patients with cirrhosis and those without. We concluded, that the formula to calculate ECV can be transferred to calculate IAC of gadoxetate disodium in hepatocytes, and, thereby, IAC may possibly qualify as an imaging-based parameter to estimate synthetic liver function.

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