scholarly journals Optical Doppler tomography and spectral Doppler imaging of localized ischemic stroke in a mouse model

2010 ◽  
Author(s):  
Lingfeng Yu ◽  
Elaine Nguyen ◽  
Gangjun Liu ◽  
Bin Rao ◽  
Bernard Choi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Mouse Model ◽  
Doppler Imaging ◽  
Doppler Tomography ◽  
Spectral Doppler ◽  
Optical Doppler Tomography

scholarly journals Hemoglobin contrast in magnetomotive optical Doppler tomography

2006 ◽  
Vol 31 (6) ◽  
pp. 778 ◽  
Author(s):  
Jeehyun Kim ◽  
Junghwan Oh ◽  
Thomas E. Milner ◽  
J. Stuart Nelson
Keyword(s):  
Doppler Tomography ◽  
Optical Doppler Tomography

Lutein enhances survival and reduces neuronal damage in a mouse model of ischemic stroke

2012 ◽  
Vol 45 (1) ◽  
pp. 624-632 ◽  
Author(s):  
Suk-Yee Li ◽  
Di Yang ◽  
Zhong Jie Fu ◽  
Tiffany Woo ◽  
David Wong ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Mouse Model ◽  
Neuronal Damage

Notch3 Mutation Detection in Stroke Patients and Selective Nanoliposome in Stroke Alleviation in a Mouse Model

2021 ◽  
Vol 17 (9) ◽  
pp. 1735-1744
Author(s):  
Yanxia Wang ◽  
Xinmeng Li ◽  
Ying Liu ◽  
Wenjing Guo ◽  
Jiangpo Chen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Mouse Model ◽  
Control Group ◽  
Stroke Therapy ◽  
Stroke Patients ◽  
Brain Vessels ◽  
Stroke Treatment ◽  
Pathological Alteration ◽  
Notch3 Mutation ◽  
Long Term Prognosis

This study analyzed the correlation between the Notch3 mutation and stroke by testing an effective nanoparticle-loaded aspirin in stroke therapy. Fifty patients with ischemic stroke were followed for two years, and fifty healthy persons served as the control group. By RT-PCR, this study revealed that the Notch3 mutation existed in ischemic stroke patients who were more likely to have a family history, small vessel lesions, relatively frequent cerebral hemorrhage, and poor long-term prognosis. Liposome-aspirin-chitosan nanoparticle (LACN) was constructed as a nano-composite for stroke treatment. Notch3 Arg170Cys knock-in mice were prepared as a mutant Notch3 mouse model to test the LACN infiltration efficiency and observe the anti-stroke capacity. We found that LACN could better transport aspirin into brain vessels than the Polyethyleneimine (PEI) delivery system. However, in the Notch3 mutation mouse model, cerebral infarction and hemorrhage often occurred after being treated with aspirin. Still, LACN better prolongs the half-life of aspirin, rescues the pathological alteration of stroke in the brain, and reduces inflammatory reaction and oxidative stress response. In conclusion, the Notch3 mutation is closely related to stroke occurrence, and LACN may be a better choice for stroke therapy in the future.

Absolute Velocity Measurement by Spectral Domain Optical Doppler Tomography

2009 ◽  
Vol 36 (10) ◽  
pp. 2561-2565
Author(s):  
孟婕 Meng Jie ◽  
丁志华 Ding Zhihua ◽  
杨勇 Yang Yong ◽  
王凯 Wang Kai ◽  
李佳纹 Li Jiawen
Keyword(s):  
Velocity Measurement ◽  
Spectral Domain ◽  
Absolute Velocity ◽  
Doppler Tomography ◽  
Optical Doppler Tomography ◽  
Absolute Velocity Measurement
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