Transferrin protein nanospheres: a nanoplatform for receptor-mediated cancer cell labeling and gene delivery

2010 ◽  
Author(s):  
Michael A. McDonald ◽  
Tighe A. Spurlin ◽  
Alessandro Tona ◽  
John T. Elliott ◽  
Michael Halter ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cancer Cell ◽  
Cell Labeling

scholarly journals Supramolecular Host–Guest Chemistry-Based Folate/Riboflavin Functionalization and Cancer Cell Labeling of Nanoparticles

ACS Omega ◽  
2017 ◽  
Vol 2 (12) ◽  
pp. 8948-8958 ◽  
Author(s):  
Suman Pal ◽  
Chumki Dalal ◽  
Nikhil R. Jana
Keyword(s):  
Cancer Cell ◽  
Cell Labeling ◽  
Guest Chemistry

Inorganic Nanoparticles and Nanomaterials Based on Titanium (Ti): Applications in Medicine

2013 ◽  
Vol 754 ◽  
pp. 21-87 ◽  
Author(s):  
Zeid A. Al Othman ◽  
Mohammad Mezbaul Alam ◽  
Mu. Naushad ◽  
Inamuddin ◽  
Mohd Farhan Khan
Keyword(s):  
Drug Delivery ◽  
Gene Delivery ◽  
Cell Tracking ◽  
Conventional Medicine ◽  
Inorganic Nanoparticles ◽  
Cell Labeling ◽  
Body Parts ◽  
Drug And Gene Delivery

Nanomedicine is a relatively new field of science and technology. By interacting with biomolecules, therefore at nanoscale, nanotechnology opens up a vast field of research and application. Current and potential applications of nanotechnology in medicine range from research involving diagnostic devices, drug delivery vehicles to enhanced gene therapy and tissue engineering procedures. Its advantage over conventional medicine lies on its size. Operating at nanoscale allows to exploit physical properties different from those observed at microscale such as the volume/surface ratio. This allows drugs of nanosize be used in lower concentration and has an earlier onset of therapeutic action. It also provides materials for controlled drug delivery by directing carriers to a specific location. Inorganic nanomedicine is likely to remain one of the most prolific fields of nanomedicine, which refers to the use of inorganic or hybrid (inorganic-inorganic or inorganic-organic) nanomaterials (INMs) and nanoparticles (INPs) to achieve innovative medical advances for body parts implantation, drug and gene discovery and delivery, discovery of biomarkers, and molecular diagnostics. Among the most promising INMs being developed are metal, silica, dendrimers, organic-inorganic hybrids, ceramics (e.g. ZrO2, TiO2, Al2O3, etc.) and bioinorganic hybrids. Metal NP contrast agents enhance magnetic resonance imaging and ultrasound results in biomedical applications of in vivo imaging. Hollow and porous INMs have been exploited for drug and gene delivery, diagnostic imaging, and photothermal therapy. Biomolecular inorganic nanohybrids and nanostructured biomaterials have been exploited for targeted imaging and therapy, drug and gene delivery, and regenerative medicine. Potential uses for fluorescent quantum dots (QDs) include cell labeling, biosensing, in vivo imaging, bimodal magnetic-luminescent imaging, and diagnostics. Biocompatible QD conjugates have been used successfully for sentinel lymph node mapping, tumor targeting, tumor angiogenesis imaging, and metastasis cell tracking. This article outlines present developments and future prospects for the use of Ti-based NPs and NMs in experimental in vivo and in vitro studies and in engineering nanodevices and biosensors for clinical and investigative use in diagnosis and therapy in diverse fields of medical sciences, such as oncology, infection control, orthopedics, dentistry, dermatology, genetics, cardiology, ophthalmology, etc. Toxicological considerations of these INPs and INMs are also discussed.

Zwitterion-functionalized dendrimer-entrapped gold nanoparticles for serum-enhanced gene delivery to inhibit cancer cell metastasis

2019 ◽  
Vol 99 ◽  
pp. 320-329 ◽  
Author(s):  
Zhijuan Xiong ◽  
Carla S. Alves ◽  
Jianhua Wang ◽  
Aijun Li ◽  
Jinyuan Liu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Gene Delivery ◽  
Cancer Cell ◽  
Cell Metastasis

Self-Assembled BolA-like Amphiphilic Peptides as Viral-Mimetic Gene Vectors for Cancer Cell Targeted Gene Delivery

2012 ◽  
Vol 13 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Jing-Xiao Chen ◽  
Xiao-Ding Xu ◽  
Shuo Yang ◽  
Juan Yang ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cancer Cell ◽  
Targeted Gene Delivery ◽  
Amphiphilic Peptides ◽  
Gene Vectors ◽  
Self Assembled

Harmonizing the Intracellular Kinetics toward Effective Gene Delivery Using Cancer Cell-Targeted and Light-Degradable Polyplexes

2017 ◽  
Vol 18 (3) ◽  
pp. 877-885 ◽  
Author(s):  
Benchun Jiang ◽  
Hua He ◽  
Li Yao ◽  
Tong Zhang ◽  
Jianping Huo ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Cancer Cell
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