Optical biopsy and tissue phantom selection: a novel approach combining single-photon timing and spatial-mode selection

2009 ◽  
Author(s):  
Luca Nardo ◽  
Maria Bondani ◽  
Alessandra Andreoni
Keyword(s):  
Single Photon ◽  
Mode Selection ◽  
Optical Biopsy ◽  
Spatial Mode ◽  
Tissue Phantom ◽  
Novel Approach

scholarly journals Spatial-Mode Selection for the Joint Transmit and Receive MMSE Design

2004 ◽  
Vol 2004 (9) ◽  
Author(s):  
Nadia Khaled ◽  
Claude Desset ◽  
Steven Thoen ◽  
Hugo De Man
Keyword(s):  
Mode Selection ◽  
Spatial Mode ◽  
Selection For

Single spatial mode selection in a layered square microcavity laser

2003 ◽  
Vol 82 (18) ◽  
pp. 2963-2965 ◽  
Author(s):  
Hee-Jong Moon ◽  
Kyungwon An ◽  
Jai-Hyung Lee
Keyword(s):  
Mode Selection ◽  
Spatial Mode ◽  
Microcavity Laser

scholarly journals FLAME: Macroscopic imaging with microscopic resolution. Optical biopsy of human skin

2020 ◽  
Author(s):  
Alexander Fast ◽  
Akarsh Lal ◽  
Amanda F. Durkin ◽  
Christopher B. Zachary ◽  
Anand K. Ganesan ◽  
...  
Keyword(s):  
Human Skin ◽  
Single Photon ◽  
Ex Vivo ◽  
Photon Counting ◽  
Optical Biopsy ◽  
Large Area ◽  
Time Resolved ◽  
Distribution Maps ◽  
Imaging Tool

AbstractWe introduce a compact, fast large area multiphoton exoscope (FLAME) system with enhanced molecular contrast for macroscopic imaging of human skin with microscopic resolution. A versatile imaging platform with multiple modes of operation for comprehensive analysis of live or resected thick human skin tissue, it produces 3D images that encompass sub-mm2 to cm2 scale areas of tissue within minutes. The FLAME imaging platform, which expands on a design recently introduced by our group, features deep learning, additional scanning hardware elements and time-resolved single photon counting detection to uniquely allow fast discrimination and 3D virtual staining of melanin. We demonstrate its performance and utility by fast ex vivo and in vivo imaging of human skin. With the ability to provide rapid access to depth resolved images of skin over cm2 area and to generate 3D distribution maps of key sub-cellular skin components such as melanocytic dendrites and melanin, FLAME represents a promising imaging tool for enhancing diagnosis accuracy, guiding therapy and understanding skin biology.

scholarly journals Analysis and experimental demonstration of spatial mode selection in a coherently combined fiber laser

2020 ◽  
Vol 28 (2) ◽  
pp. 1854
Author(s):  
Erik Tilseth ◽  
W. Minster Kunkel ◽  
James R. Leger
Keyword(s):  
Fiber Laser ◽  
Mode Selection ◽  
Spatial Mode ◽  
Experimental Demonstration
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