Electro-magnetic free energy transduction by molecular motors

2009 ◽  
Author(s):  
V. V. Yakovlev
Keyword(s):  
Free Energy ◽  
Molecular Motors ◽  
Energy Transduction ◽  
Magnetic Free Energy ◽  
Electro Magnetic

From ATP to Electron Transfer:  Electrostatics and Free-Energy Transduction in Nitrogenase

2001 ◽  
Vol 105 (23) ◽  
pp. 5359-5367 ◽  
Author(s):  
I. V. Kurnikov ◽  
A. K. Charnley ◽  
D. N. Beratan
Keyword(s):  
Electron Transfer ◽  
Free Energy ◽  
Energy Transduction

Energy Transduction by the Two Molecular Motors of the F1Fo ATP Synthase

2011 ◽  
pp. 561-590 ◽  
Author(s):  
David Spetzler ◽  
Robert Ishmukhametov ◽  
Tassilo Hornung ◽  
James Martin ◽  
Justin York ◽  
...  
Keyword(s):  
Atp Synthase ◽  
Molecular Motors ◽  
Energy Transduction ◽  
F1fo Atp Synthase

scholarly journals Theory of Nonequilibrium Free Energy Transduction by Molecular Machines

2019 ◽  
Vol 120 (1) ◽  
pp. 434-459 ◽  
Author(s):  
Aidan I. Brown ◽  
David A. Sivak
Keyword(s):  
Free Energy ◽  
Molecular Machines ◽  
Energy Transduction

Computational analysis of hereditary spastic paraplegia mutations in the kinesin motor domains of KIF1A and KIF5A

2020 ◽  
Vol 19 (06) ◽  
pp. 2041003
Author(s):  
Vidhyanand Mahase ◽  
Adebiyi Sobitan ◽  
Christina Johnson ◽  
Farion Cooper ◽  
Yixin Xie ◽  
...  
Keyword(s):  
Free Energy ◽  
Protein Stability ◽  
Molecular Motors ◽  
Intracellular Transport ◽  
Computational Analysis ◽  
Binding Free Energy ◽  
Membrane Vesicles ◽  
Energy Calculation ◽  
Missense Mutations ◽  
Kinesin Motor

Hereditary spastic paraplegias (HSPs) are a genetically heterogeneous collection of neurodegenerative disorders categorized by progressive lower-limb spasticity and frailty. The complex HSP forms are characterized by various neurological features including progressive spastic weakness, urinary sphincter dysfunction, extra pyramidal signs and intellectual disability (ID). The kinesin superfamily proteins (KIFs) are microtubule-dependent molecular motors involved in intracellular transport. Kinesins directionally transport membrane vesicles, protein complexes, and mRNAs along neurites, thus playing important roles in neuronal development and function. Recent genetic studies have identified kinesin mutations in patients with HSPs. In this study, we used the computational approaches to investigate the 40 missense mutations associated with HSP and ID in KIF1A and KIF5A. We performed homology modeling to construct the structures of kinesin–microtubule binding domain and kinesin–tubulin complex. We applied structure-based energy calculation methods to determine the effects of missense mutations on protein stability and protein–protein interaction. The results revealed that the most of disease-causing mutations could change the folding free energy of kinesin motor domain and the binding free energy of kinesin–tubulin complex. We found that E253K associated with ID in KIF1A decrease the protein stability of kinesin motor domains. We showed that the HSP mutations located in kinesin–tubulin complex interface, such as K253N and R280C in KIF5A, can destabilize the kinesin–tubulin complex. The computational analysis provides useful information for understanding the roles of kinesin mutations in the development of ID and HSPs.

scholarly journals Reconstructing the free-energy landscape associated to molecular motors processivity

2012 ◽  
Vol 167 ◽  
pp. 16-25 ◽  
Author(s):  
Nazul Jared López Alamilla ◽  
Ivan Santamaría Holek
Keyword(s):  
Free Energy ◽  
Molecular Motors ◽  
Energy Landscape ◽  
Free Energy Landscape

scholarly journals Interacting Magnetospheres in RS CVn Binaries – Coronal Heating and Flares

1983 ◽  
Vol 71 ◽  
pp. 629-632
Author(s):  
Y. Uchida ◽  
T. Sakurai
Keyword(s):  
Free Energy ◽  
Magnetic Fields ◽  
Binary Systems ◽  
Coronal Heating ◽  
Close Binary ◽  
Magnetic Free Energy ◽  
Close Binary Systems

AbstractCoronae and flares of RS CVn systems are interpreted as due to gradual and sudden releases of magnetic free energy which is built up throught the interaction of magnetic fields of stars in these close binary systems.

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