A high sensitivity multi-spectral three-dimensional fluorescence optical tomography system for small animal imaging

2009 ◽  
Author(s):  
Changqing Li ◽  
Gregory S. Mitchell ◽  
Joyita Dutta ◽  
Sangtae Ahn ◽  
Richard M. Leahy ◽  
...  
Keyword(s):  
Optical Tomography ◽  
Small Animal Imaging ◽  
Three Dimensional ◽  
Small Animal ◽  
High Sensitivity ◽  
Tomography System ◽  
Animal Imaging

scholarly journals Volumetric Diffuse Optical Tomography for Small Animals Using a CCD-Camera-Based Imaging System

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Zi-Jing Lin ◽  
Haijing Niu ◽  
Lin Li ◽  
Hanli Liu
Keyword(s):  
Imaging System ◽  
Optical Tomography ◽  
Small Animal Imaging ◽  
Three Dimensional ◽  
Diffuse Optical Tomography ◽  
Small Animal ◽  
Ccd Camera ◽  
Animal Imaging ◽  
Volumetric Images ◽  
Phantom Studies

We report the feasibility of three-dimensional (3D) volumetric diffuse optical tomography for small animal imaging by using a CCD-camera-based imaging system with a newly developed depth compensation algorithm (DCA). Our computer simulations and laboratory phantom studies have demonstrated that the combination of a CCD camera and DCA can significantly improve the accuracy in depth localization and lead to reconstruction of 3D volumetric images. This approach may present great interests for noninvasive 3D localization of an anomaly hidden in tissue, such as a tumor or a stroke lesion, for preclinical small animal models.

scholarly journals Multi-modal molecular diffuse optical tomography system for small animal imaging

2013 ◽  
Vol 24 (10) ◽  
pp. 105405 ◽  
Author(s):  
James A Guggenheim ◽  
Hector R A Basevi ◽  
Jon Frampton ◽  
Iain B Styles ◽  
Hamid Dehghani
Keyword(s):  
Optical Tomography ◽  
Small Animal Imaging ◽  
Diffuse Optical Tomography ◽  
Small Animal ◽  
Tomography System ◽  
Animal Imaging

scholarly journals Numerical simulation of x-ray luminescence optical tomography for small-animal imaging

2014 ◽  
Vol 19 (4) ◽  
pp. 046002 ◽  
Author(s):  
Changqing Li ◽  
Arnulfo Martínez-Dávalos ◽  
Simon R. Cherry
Keyword(s):  
Numerical Simulation ◽  
Optical Tomography ◽  
Small Animal Imaging ◽  
Small Animal ◽  
X Ray ◽  
Animal Imaging

scholarly journals Small animal imaging using a curved array photoacoustic tomography system

2008 ◽  
Author(s):  
John Gamelin ◽  
Andres Aguirre ◽  
Anastasios Maurudis ◽  
Fei Huang ◽  
Diego Castillo ◽  
...  
Keyword(s):  
Small Animal Imaging ◽  
Small Animal ◽  
Photoacoustic Tomography ◽  
Tomography System ◽  
Animal Imaging

A Three-Dimensional Registration Method for MicroUS/MicroPET Multimodality Small-Animal Imaging

2007 ◽  
Vol 29 (3) ◽  
pp. 155-166 ◽  
Author(s):  
Ai-Ho Liao ◽  
Li-Yen Chen ◽  
Wen-Fang Cheng ◽  
Pai-Chi Li
Keyword(s):  
Image Registration ◽  
Structural Information ◽  
Multimodality Imaging ◽  
Imaging Techniques ◽  
Small Animal Imaging ◽  
Three Dimensional ◽  
Small Animal ◽  
Imaging Method ◽  
Registration Method ◽  
Animal Imaging

Small-animal models are used extensively in disease research, genomics research, drug development and developmental biology. The development of noninvasive small-animal imaging techniques with adequate spatial resolution and sensitivity is therefore of prime importance. In particular, multimodality small-animal imaging can provide complementary information. This paper presents a method for registering high-frequency ultrasonic (microUS) images with small-animal positron-emission tomography (microPET) images. Registration is performed using six external multimodality markers, each being a glass bead with a diameter of 0.43–0.60 mm, with 0.1 μl of [18F]FDG placed in each marker holder. A small-animal holder is used to transfer mice between the microPET and microUS systems. Multimodality imaging was performed on C57BL/6J black mice bearing WF-3 ovary cancer cells in the second week after tumor implantation and rigid-body image registration of the six markers was also performed. The average registration error was 0.31 mm when all six markers were used and increased as the number of markers decreased. After image registration, image segmentation and fusion are performed on the tumor. Our multimodality small-animal imaging method allows structural information from microUS to be combined with functional information from microPET, with the preliminary results showing it to be an effective tool for cancer research.

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