The optical properties of biological tissues in the terahertz wavelength range

Author(s):  
Gerald J. Wilmink ◽  
Benjamin D. Rivest ◽  
Bennett L. Ibey ◽  
Luisiana X. Cundin ◽  
Eric C. Haywood ◽  
...  
2021 ◽  
Vol 27 (1) ◽  
pp. 99-107
Author(s):  
Ali Shahin ◽  
Wesam Bachir ◽  
Moustafa Sayem El-Daher

Abstract Introduction: Due to enormous interests for laser in medicine and biology, optical properties characterization of different tissue have be affecting in development processes. In addition, the optical properties of biological tissues could be influenced by storage methods. Thus, optical properties of bovine white and grey tissues preserved by formalin have been characterized over a wide wavelength spectrum varied between 440 nm and 1000 nm. Materials and Methods: To that end, a single integrating sphere system was assembled for spectroscopic characterization and an inverse adding-doubling algorithm was used to retrieve optical coefficients, i.e. reduced scattering and absorption coefficients. Results: White matter has shown a strong scattering property in comparison to grey matter. On the other hand, the grey matter has absorbed light extensively. In comparison, the reduced scattering profile for both tissue types turned out to be consistent with prior works that characterized optical coefficients in vivo. On the contrary, absorption coefficient behavior has a different feature. Conclusion: Formalin could change the tissue’s optical properties because of the alteration of tissue’s structure and components. The absence of hemoglobin that seeps out due to the use of a formalin could reduce the absorption coefficient over the visible range. Both the water replacement by formalin could reduce the refractive index of a stored tissue and the absence of hemoglobin that scatters light over the presented wavelength range should diminish the reduced scattering coefficients over that wavelength range.


1983 ◽  
Vol 12 (4) ◽  
pp. 137-139
Author(s):  
A. A. El-Shazly ◽  
M. K. Kenawi ◽  
H. T. El-Shair ◽  
M. M. El-Nahass ◽  
H. S. Soliman

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Brett H. Hokr ◽  
Joel N. Bixler

AbstractDynamic, in vivo measurement of the optical properties of biological tissues is still an elusive and critically important problem. Here we develop a technique for inverting a Monte Carlo simulation to extract tissue optical properties from the statistical moments of the spatio-temporal response of the tissue by training a 5-layer fully connected neural network. We demonstrate the accuracy of the method across a very wide parameter space on a single homogeneous layer tissue model and demonstrate that the method is insensitive to parameter selection of the neural network model itself. Finally, we propose an experimental setup capable of measuring the required information in real time in an in vivo environment and demonstrate proof-of-concept level experimental results.


2017 ◽  
Vol 11 (2) ◽  
pp. e201700076 ◽  
Author(s):  
Helene Isler ◽  
Catherine Germanier ◽  
Linda Ahnen ◽  
Jingjing Jiang ◽  
Scott Lindner ◽  
...  

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Marisela Rodriguez-Salvador

Optical tissue phantoms enable to mimic the optical properties of biological tissues for biomedical device calibration, new equipment validation, and clinical training for the detection, and treatment of diseases. Unfortunately, current methods for their development present some problems, such as a lack of repeatability in their optical properties. Where the use of three-dimensional (3D) printing or 3D bioprinting could address these issues. This paper aims to evaluate the use of this technology in the development of optical tissue phantoms. A competitive technology intelligence methodology was applied by analyzing Scopus, Web of Science, and patents from January 1, 2000, to July 31, 2018. The main trends regarding methods, materials, and uses, as well as predominant countries, institutions, and journals, were determined. The results revealed that, while 3D printing is already employed (in total, 108 scientific papers and 18 patent families were identified), 3D bioprinting is not yet applied for optical tissue phantoms. Nevertheless, it is expected to have significant growth. This research gives biomedical scientists a new window of opportunity for exploring the use of 3D bioprinting in a new area that may support testing of new equipment and development of techniques for the diagnosis and treatment of diseases.


2000 ◽  
Author(s):  
P. L. Kopsombut ◽  
D. Willis ◽  
A. E. Schen ◽  
L. X. Xu ◽  
X. Xu

Abstract Along with rapid development of diagnostic and therapeutic applications of lasers in medicine, optical properties of various biological tissues have been extensively studied [1]. Most of the studies were performed in vitro owing to the complexity involved in in vivo measurement. To date, it is well understood that living tissue is an absorbing and scattering heterogeneous medium because of its complex structures including blood network. The transport theory cannot be readily used due to the heterogeneity and the absence of the optical properties of living tissues [2]. In this research, we have developed a procedure for measuring the total attenuation coefficient (μ1) of the exteriorized rat 2-D spinotrapezius muscle in the wavelength ranged from 480–560 nm using the collimated light from a Nitrogen-pumped dye laser and a high-sensitivity CCD camera.


1975 ◽  
Vol 15 (73) ◽  
pp. 363-372 ◽  
Author(s):  
J. W. Lane

AbstractThe dependence of the extinction coefficient on salinity was investigated for both NaCl-ice and salt-ice made from natural sea-water. Specimens were prepared under a variety of conditions and examined over the wavelength range 4 000 to 8 000 Â. The effects of scattering from air bubbles trapped in the ice were examined for ice made from distilled water. It was found that the method of preparing samples markedly affected their structure, but that, when prepared in the same manner, salt-ice made from natural sea-water and NaCl-ice did not show significantly different transmission properties. It was found that, for a wavelength of 6 328 Â, the data could be fit to the relationwithin an uncertainty of 26%, wherekeis the extinction coefficient,xis the salinity of the ice in g/kg. Within an uncertainty of 10%, there was no variation in transmission for ice at the same temperature and salinity over the wavelength range 4 000 to 8 000 Â. All measurements were made at a temperature of -20° C.


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