Micro-polarimetry for pre-clinical diagnostics of pathological changes in human tissues

2008 ◽  
Author(s):  
Andrzej Golnik ◽  
Natalia Golnik ◽  
Tadeusz Pałko ◽  
Tomasz Sołtysiński
Keyword(s):  
Clinical Diagnostics ◽  
Human Tissues ◽  
Pathological Changes

scholarly journals The Interconnection between the Coordinate Distribution of Mueller-Matrixes Images Characteristic Values of Biological Liquid Crystals Net and the Pathological Changes of Human Tissues

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Oleg V. Angelsky ◽  
Yuriy A. Ushenko ◽  
Alexander V. Dubolazov ◽  
Olha Yu. Telenha
Keyword(s):  
Liquid Crystals ◽  
Human Tissue ◽  
Mueller Matrix ◽  
Human Tissues ◽  
Matrix Elements ◽  
Pathological Changes ◽  
Crystal Network ◽  
Characteristic Points ◽  
Biological Liquid ◽  
Characteristic Values

We have theoretically grounded conceptions of characteristic points observed in coordinate distributions of Mueller matrix elements for a network of human tissue biological crystals. The interrelation between polarization singularities of laser images inherent to these biological crystals and characteristic values of above matrix elements is found. We have determined the criteria for statistical diagnostics of pathological changes in the birefringent structure of biological crystal network by using myometrium tissue as an example.

scholarly journals On the Feasibilities of Using the Wavelet Analysis of Mueller Matrix Images of Biological Crystals

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
O. V. Dubolazov ◽  
A. G. Ushenko ◽  
V. T. Bachynsky ◽  
A. P. Peresunko ◽  
O. Ya. Vanchulyak
Keyword(s):  
Wavelet Analysis ◽  
Power Spectra ◽  
Mueller Matrix ◽  
Phase Changes ◽  
Statistical Moments ◽  
Human Tissues ◽  
Wavelet Coefficients ◽  
Pathological Changes ◽  
Crystal Network ◽  
Fractal Analyses

The efficiency of using the statistical and fractal analyses for distributions of wavelet coefficients for Mueller matrix images of biological crystal networks inherent to human tissues is theoretically grounded in this work. The authors found interrelations between statistical moments and power spectra for distributions of wavelet coefficients as well as orientation-phase changes in networks of biological crystals. Also determined are the criteria for statistical and fractal diagnostics of changes in the birefringent structure of biological crystal network, which corresponds to pathological changes in tissues.

scholarly journals Anything You Can Do, I Can Do Better: Can Aptamers Replace Antibodies in Clinical Diagnostic Applications?

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4377 ◽  
Author(s):  
Michelle Bauer ◽  
Mia Strom ◽  
David S Hammond ◽  
Sarah Shigdar
Keyword(s):  
Clinical Diagnostics ◽  
Molecular Probe ◽  
Pathological Changes ◽  
Clinical Environment ◽  
Clinical Diagnostic ◽  
Diagnostic Applications

The mainstay of clinical diagnostics is the use of specialised ligands that can recognise specific biomarkers relating to pathological changes. While protein antibodies have been utilised in these assays for the last 40 years, they have proven to be unreliable due to a number of reasons. The search for the ‘perfect’ targeting ligand or molecular probe has been slow, though the description of chemical antibodies, also known as aptamers, nearly 30 years ago suggested a replacement reagent. However, uptake has been slow to progress into the clinical environment. In this review, we discuss the issues associated with antibodies and describe some of the applications of aptamers that have relevancy to the clinical diagnostic environment.

scholarly journals Humano vs. maniquíes: los límites éticos de la simulación de la vía aérea en los pacientes

2019 ◽  
Vol 11 (10) ◽  
pp. 3
Author(s):  
Miriam Sánchez Merchante ◽  
Eugenio Martínez Hurtado ◽  
Marisa Mariscal Flores
Keyword(s):  
Cervical Spine ◽  
Human Tissues ◽  
Pathological Changes ◽  
Spine Mobility ◽  
Real Patients

La investigación en anestesia está, sin duda, dominada por estudios basados ​​en maniquíes, a pesar de las dudas existentes acerca de la validez de extrapolar sus hallazgos a pacientes reales. Los maniquíes no pueden aún reproducir con total precisión la anatomía de la vía aérea del paciente, careciendo, en particular, de la capacidad de replicar la sensación y la textura de los tejidos humanos, la movilidad de la columna cervical, la variabilidad de las proporciones anatómicas y los cambios patológicos. Todo lo cual resulta en una falta crítica de fidelidad. ABSTRACT Human vs. Mannequins: ethical boundaries of airway simulation in patients. Research in anaesthesia is dominated without any doubt, by studies based on mannequins, despite the existing doubts about the validity of extrapolate its revelations to real patients. Mannequins are not able to fully reproduce the airway patient´s anatomy, lacking the ability of replicate specially human tissues´ structure and sensation, cervical spine mobility, anatomic proportions variability and pathological changes, which results in a critical allegiance failure.

Microstructural comparison of synthetic bioceramics with natural bioceramics

1991 ◽  
Vol 49 ◽  
pp. 38-39
Author(s):  
Shulin Wen ◽  
Jingwei Feng ◽  
A. Krajewski ◽  
A. Ravaglioli
Keyword(s):  
Recent Work ◽  
Human Body ◽  
Human Tissues ◽  
Main Constituent ◽  
Laboratory Furnace ◽  
Chinese Adult ◽  
Human Enamel ◽  
Biological Compatibility ◽  
Synthetic Hydroxyapatite ◽  
Synthetic Work

Hydroxyapatite bioceramics has attracted many material scientists as it is the main constituent of the bone and the teeth in human body. The synthesis of the bioceramics has been performed for years. Nowadays, the synthetic work is not only focused on the hydroapatite but also on the fluorapatite and chlorapatite bioceramics since later materials have also biological compatibility with human tissues; and they may also be very promising for clinic purpose. However, in comparison of the synthetic bioceramics with natural one on microstructure, a great differences were observed according to our previous results. We have investigated these differences further in this work since they are very important to appraise the synthetic bioceramics for their clinic application.The synthetic hydroxyapatite and chlorapatite were prepared according to A. Krajewski and A. Ravaglioli and their recent work. The briquettes from different hydroxyapatite or chlorapatite powders were fired in a laboratory furnace at the temperature of 900-1300°C. The samples of human enamel selected for the comparison with synthetic bioceramics were from Chinese adult teeth.

Reversal of cardiomyopathy resulting from prenatal exposure to ethanol

1984 ◽  
Vol 42 ◽  
pp. 716-717
Author(s):  
C. Uphoff ◽  
C. Nyquist-Battie
Keyword(s):  
Prenatal Exposure ◽  
Heart Development ◽  
Membrane Integrity ◽  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
Pathological Changes ◽  
Prenatally Exposed ◽  
Inner Mitochondrial Membrane ◽  
Fetal Alcohol ◽  
Newborn Mice

Fetal Alcohol Syndrone (FAS) is a syndrome with characteristic abnormalities resulting from prenatal exposure to ethanol. In many children with FAS syndrome gross pathological changes in the heart are seen with septal defects the most prevalent abnormality recorded. Few studies in animal models have been performed on the effects of ethanol on heart development. In our laboratory, it has been observed that prenatal ethanol exposure of Swiss albino mice results in abnormal cardiac muscle ultrastructure when mice were examined at birth and compared to pairfed and normal controls. Fig. 1 is an example of the changes that are seen in the ethanol-exposed animals. These changes include enlarged mitochondria with loss of inner mitochondrial membrane integrity and loss of myofibrils. Morphometric analysis substantiated the presence of these alterations from normal cardiac ultrastructure. The present work was undertaken to determine if the pathological changes seen in the newborn mice prenatally exposed to ethanol could be reversed with age and abstinence.

Immunoelectron microscopic localization of elastic tissue in archival material using an improved method

1990 ◽  
Vol 48 (3) ◽  
pp. 794-795
Author(s):  
J. C. Fanning ◽  
J. F. White ◽  
R. Polewski ◽  
E. G. Cleary
Keyword(s):  
Normal Animal ◽  
Animal Tissue ◽  
Elastic Tissue ◽  
Human Tissues ◽  
Improved Method ◽  
Tissue Samples ◽  
Archival Material ◽  
Immuno Electron Microscopy ◽  
Arteries And Veins ◽  
Biochemical Examination

Elastic tissue is an important component of the walls of arteries and veins, of skin, of the lungs and in lesser amounts, of many other tissues. It is responsible for the rubber-like properties of the arteries and for the normal texture of young skin. It undergoes changes in a number of important diseases such as atherosclerosis and emphysema and on exposure of skin to sunlight.We have recently described methods for the localizationof elastic tissue components in normal animal and human tissues. In the study of developing and diseased tissues it is often not possible to obtain samples which have been optimally prepared for immuno-electron microscopy. Sometimes there is also a need to examine retrospectively samples collected some years previously. We have therefore developed modifications to our published methods to allow examination of human and animal tissue samples obtained at surgery or during post mortem which have subsequently been: 1. stored frozen at -35° or -70°C for biochemical examination; 2.

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