Utility of point of care test devices for infectious disease testing of blood and oral fluid and application to rapid testing in the field

2008 ◽  
Author(s):  
Stephen R. Lee ◽  
Keith W. Kardos ◽  
Graham D. Yearwood ◽  
Geraldine B. Guillon ◽  
Lisa A. Kurtz ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Oral Fluid ◽  
Point Of Care ◽  
Rapid Testing ◽  
Point Of Care Test ◽  
Disease Testing

Performance of a Rapid, Point-of-Care Test for Chlamydia Trachomatis and Women’s Attitudes Towards Rapid Testing

2017 ◽  
Vol 60 (2) ◽  
pp. S117 ◽  
Author(s):  
Lea E. Widdice ◽  
DeAnna Owens ◽  
Barbara Silver ◽  
Mathilda Barnes ◽  
Perry Barnes ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Point Of Care ◽  
Rapid Testing ◽  
Point Of Care Test

scholarly journals Evaluation of a Rapid Oral Fluid Point-of-Care Test for MDMA

2007 ◽  
Vol 31 (2) ◽  
pp. 98-104 ◽  
Author(s):  
L. Wilson ◽  
A. Jehanli ◽  
C. Hand ◽  
G. Cooper ◽  
R. Smith
Keyword(s):  
Oral Fluid ◽  
Point Of Care ◽  
Point Of Care Test

scholarly journals aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 562 ◽  
Author(s):  
Hanna Lähteenmäki ◽  
Kehinde A. Umeizudike ◽  
Anna Maria Heikkinen ◽  
Ismo T. Räisänen ◽  
Nilminie Rathnayake ◽  
...  
Keyword(s):  
Medical Care ◽  
Oral Fluid ◽  
Care Setting ◽  
Point Of Care ◽  
Active Matrix ◽  
Non Invasive ◽  
Point Of Care Test ◽  
Essential Value ◽  
Periodontal Breakdown ◽  
Periodontal Diagnostics

This communication article addresses currently available rapid non-invasive methods to screen and detect periodontitis and dental peri-implantitis. In this regard, oral fluid biomarkers have been researched extensively but self-reported oral health (SROH)-questionnaires have also been developed. Both alternatives may offer a quick and easy way to screen and detect diseased patients. Active matrix metalloproteinase (aMMP-8) is one of the most validated biomarkers for screening and detecting periodontal breakdown related to periodontitis and peri-implantitis and monitoring their treatment effects revealing successful, less- and non-successful treatment results. Currently available aMMP-8 lateral-flow technologies allow this kind of analysis, as demonstrated here, to be conducted quantitatively online and real-time as point-of-care/chairside testing in dental and even medical care settings. In this study, an aMMP-8 peri-implant sulcular fluid point-of-care-test diagnosed peri-implantitis and healthy implants far more accurately than bleeding-on-probing or the other biomarkers, such as polymorphonuclear (PMN)/neutrophil elastase, myeloperoxidase and MMP-9. Although, SROH-questionnaires allow screening in similar settings but they lack the information about the current disease activity of periodontitis and peri-implantitis, which is of essential value in periodontal diagnostics and treatment monitoring. Thus, both methods can be considered as adjunct methods for periodontitis and peri-implant diagnostics, but the value of oral fluid biomarkers analysis does not seem to be substitutable.

Multiplex SARS-CoV-2 RT-qPCR protocol v1

2021 ◽  
Author(s):  
Peter H L Krijger ◽  
Tim A Hoek ◽  
Sanne Boersma ◽  
Lieke I P M Donders ◽  
Maaike M C Broeders ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Hepatitis C ◽  
Real Time ◽  
Internal Control ◽  
Point Of Care ◽  
Rt Pcr ◽  
Pcr Assay ◽  
Reverse Transcription Pcr ◽  
Point Of Care Test ◽  
Novel Coronavirus

An in-house multiplex RT-qPCR , targeting SARS-CoV-2and PDV as internal control [1][2], developed on QuantStudio 7 Pro Real-Time PCR Systems using Life Technologies Taqman FastVirus 1-step mastermix with E-gene primers and probe as described by Corman et al. and N1 primers and probes as described by the CDC[3, 4]. 1.Clancy, A. eta al., The development of a qualitative real-time RT-PCR assay for the detection of hepatitis C virus European Journal Microbial Infectious Diseases, 2008. 276(12): p.1177. 2.Wolters, F., et al., Multi-center evaluation of cepheid xpert® xpress SARS-CoV-2 point-of-care test during the SARS-CoV-2 pandemic. Journal of Clinical Virology, 2020. 128: p. 104426 3.Corman, V.M., et al., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill, 2020. 25(3). 4.Lu, X., et al., US CDC Real-Time Reverse Transcription PCR Panel for Detection of Severe Acute Respiratory Syndrome Coronavirus 2.Emerging Infectious Disease journal, 2020. 26(8): p. 1654.

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