Blue laser system for photo-dynamic therapy

2007 ◽  
Author(s):  
R. Dabu ◽  
B. Carstocea ◽  
C. Blanaru ◽  
O. Pacala ◽  
A. Stratan ◽  
...  
2018 ◽  
Vol 08 (04) ◽  
pp. 024-027
Author(s):  
Shiny Inasu ◽  
Biju Thomas

AbstractA novel noninvasive photochemical approach for infection control, namely photodynamic therapy, has received much attention in the treatment of oral diseases which requires three nontoxic ingredients namely visible harmless light, a photosensitizer and oxygen are involved in this therapy. It is based on the principle that a photosensitizer binds to the target cells which when activated by light of a suitable wavelength results in the production of singlet oxygen and other very reactive agents that are extremely toxic to certain cells and bacteria. This article highlights the application of photo-dynamic therapy in management of periodontal disease and its current status.


2017 ◽  
Vol 7-8 ◽  
pp. 46-51
Author(s):  
Leila Karami-Gadallo ◽  
Mahmood Ghoranneviss ◽  
Leila Ataie-Fashtami ◽  
Majid Pouladian ◽  
Dariush Sardari

Author(s):  
Jean-Philippe M. Fève ◽  
Mathew Finuf ◽  
Robert Fritz ◽  
M. Greenlief ◽  
Donald Millick ◽  
...  

2013 ◽  
Vol 12 (1) ◽  
pp. e600
Author(s):  
S. Agrawal ◽  
E. Havrenak ◽  
D. Hrouda ◽  
A. Shamsuddin

Urology ◽  
1997 ◽  
Vol 50 (2) ◽  
pp. 199-206 ◽  
Author(s):  
McClellan M. Walther ◽  
Thomas F. Delaney ◽  
Paul D. Smith ◽  
Walter S. Friauf ◽  
Gunter F. Thomas ◽  
...  

1993 ◽  
Vol 11 (1) ◽  
pp. 89-96 ◽  
Author(s):  
H. Nishimura ◽  
H. Shiraga ◽  
T. Endo ◽  
H. Takabe ◽  
M. Katayama ◽  
...  

In the last few years, systematic studies on radiation hydrodynamics in the X-ray confining cavity and a fuel capsule have attained remarkable progress. This makes it possible to analyze quantitatively the energy transfer processes from laser to the fusion capsule and find uniform irradiation conditions of the fusion capsule driven by thermal X rays. As a result, reproducible and stable implosions were achieved. Throughout implosion experiments with the Gekko XII blue laser system (351 nm, kJ, 0.8 ns), good agreement of implosion has been obtained between the experiment and numerical simulations, assuming perfectly spherical symmetry, up to a radial convergence ratio of 15. Described are particularly the issues of (1) energy transfer processes from laser to a fuel capsule and conditions for uniform irradiation, (2) properties of the X-ray propagation through aluminum heated by X-ray radiation, and (3) dependence of the convergence ratio of Ri/Rf (where Ri and Rf are the initial and final radii) of the capsule on the initial fill pressure of D–T gas and its influence on the core parameters and fusion products to evaluate implosion sphericity.


2021 ◽  
Author(s):  
Stefano Perni ◽  
Emily Preedy ◽  
Polina Prokopovich

Abstract Light-activated antimicrobial agents (photosensitisers) are promising alternatives to antibiotics for the treatment of skin infections and wounds through antimicrobial Photo Dynamic Therapy (aPDT); utilisation of this technique is still restricted by general low efficacy requiring long exposure time (in the order of tens of minutes) that make the treatment very resource intensive. We report for the first time the possibility of harvesting the cell penetrating properties of poly-beta-amino esters (PBAEs) in combination with toluidine blue O (TBO) to shorten aPDT exposure time. Candidates capable of inactivation rates 30 times quicker than pure TBO were discovered and further improvements through PBAE backbone optimisation could be foreseen. Efficacy of the complexes was PBAE-dependent on a combination of TBO uptake and a newly discovered and unexpected role of PBAEs on reactive species production. Chemometric approach of partial least square regression was employed to assess the critical PBAE properties involved in this newly observed phenomenon in order to elicit a possible mechanism.The superior antimicrobial performance of this new approach benefits from the use of well established, low-cost and safe dye (TBO) coupled with inexpensive, widely tested and biodegradable polymers also known to be safe. Moreover, no adverse cytotoxic effects of the PBAEs adjuvated TBO delivery have been observed on a skin cells in vitro model demonstrating the safety profile of this new technology.


1986 ◽  
Vol 6 (3) ◽  
pp. 77-80
Author(s):  
Yusuke Kuroda ◽  
Hiroto Kuroda ◽  
Yuichi Tanaka ◽  
Yoshihiko Kanemitsu ◽  
Tadayoshi Takemoto ◽  
...  

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