Time-resolved fluorescence measurements for diffuse optical tomography using ultrafast time-correlated single photon counting

2006 ◽  
Author(s):  
Yves Bérubé-Lauzière ◽  
Vincent Robichaud
Keyword(s):  
Single Photon ◽  
Optical Tomography ◽  
Photon Counting ◽  
Diffuse Optical Tomography ◽  
Time Resolved Fluorescence ◽  
Time Resolved ◽  
Single Photon Counting ◽  
Fluorescence Measurements

Time-resolved fluorescence from biological systems: tryptophan and simple peptides

1980 ◽  
Vol 298 (1439) ◽  
pp. 321-334 ◽  
Keyword(s):  
Time Resolution ◽  
Single Photon ◽  
Photon Counting ◽  
Time Resolved Fluorescence ◽  
Time Resolved ◽  
Single Photon Counting ◽  
Fluorescence Measurements ◽  
Mode Locked Lasers ◽  
Electron Transfers ◽  
Sensitive Method

Four methods of applying mode-locked lasers to time-resolved fluorescence measurements in the subnanosecond region are compared. When time resolution below 100 ps is not required, the most precise and sensitive method is single-photon counting, and the application of this method to studies of time-resolved fluorescence of tryptophan in simple peptides is described. The dependence of lifetimes on pH and temperature are interpreted in terms of quenching by intramolecular proton and electron transfers.

Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography

2005 ◽  
Author(s):  
Wolfgang Becker ◽  
Axel Bergmann ◽  
Adam Gibson ◽  
Nick Everdell ◽  
David Jennions ◽  
...  
Keyword(s):  
Single Photon ◽  
Optical Tomography ◽  
Photon Counting ◽  
Diffuse Optical Tomography ◽  
Single Photon Counting

scholarly journals Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging

2016 ◽  
Vol 2016 ◽  
pp. 1-23 ◽  
Author(s):  
Yves Bérubé-Lauzière ◽  
Matteo Crotti ◽  
Simon Boucher ◽  
Seyedrohollah Ettehadi ◽  
Julien Pichette ◽  
...  
Keyword(s):  
Temporal Resolution ◽  
Time Domain ◽  
Single Photon ◽  
Optical Tomography ◽  
Photon Counting ◽  
Diffuse Optical Tomography ◽  
Small Animal ◽  
Acquisition Time ◽  
High Temporal Resolution ◽  
Single Photon Counting

This paper discusses instrumentation based on multiview parallel high temporal resolution (<50 ps) time-domain (TD) measurements for diffuse optical tomography (DOT) and a prospective view on the steps to undertake as regards such instrumentation to make TD-DOT a viable technology for small animal molecular imaging. TD measurements provide information-richest data, and we briefly review the interaction of light with biological tissues to provide an understanding of this. This data richness is yet to be exploited to its full potential to increase the spatial resolution of DOT imaging and to allow probing, via the fluorescence lifetime, tissue biochemical parameters, and processes that are otherwise not accessible in fluorescence DOT. TD data acquisition time is, however, the main factor that currently compromises the viability of TD-DOT. Current high temporal resolution TD-DOT scanners simply do not integrate sufficient detection channels. Based on our past experience in developing TD-DOT instrumentation, we review and discuss promising technologies to overcome this difficulty. These are single photon avalanche diode (SPAD) detectors and fully parallel highly integrated electronics for time-correlated single photon counting (TCSPC). We present experimental results obtained with such technologies demonstrating the feasibility of next-generation multiview TD-DOT therewith.

A Low-Cost Time-Correlated Single Photon Counting System for Multiview Time-Domain Diffuse Optical Tomography

2017 ◽  
Vol 66 (10) ◽  
pp. 2505-2515 ◽  
Author(s):  
Jonathan Bouchard ◽  
Arnaud Samson ◽  
William Lemaire ◽  
Caroline Paulin ◽  
Jean-Francois Pratte ◽  
...  
Keyword(s):  
Time Domain ◽  
Single Photon ◽  
Low Cost ◽  
Optical Tomography ◽  
Photon Counting ◽  
Diffuse Optical Tomography ◽  
Counting System ◽  
Single Photon Counting
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