Confocal Raman microspectroscopy: measuring the effects of topical moisturizers on stratum corneum water gradient in vivo

2006 ◽  
Author(s):  
Anke Sieg ◽  
Jonathan Crowther ◽  
Peter Blenkiron ◽  
Curtis Marcott ◽  
Paul J. Matts
Keyword(s):  
Stratum Corneum ◽  
Raman Microspectroscopy ◽  
Water Gradient ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

scholarly journals Current views on non-invasive in vivo determination of physiological parameters of the stratum corneum using confocal Raman microspectroscopy

2022 ◽  
Author(s):  
Maxim E. Darvin ◽  
Johannes Schleusener ◽  
Jürgen Lademann ◽  
Chun-Sik Choe
Keyword(s):  
Stratum Corneum ◽  
Raman Microspectroscopy ◽  
Physiological Parameters ◽  
Skin Barrier Function ◽  
Non Invasive ◽  
Intercellular Lipids ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

Confocal Raman microspectroscopy is widely used in dermatology and cosmetology for analysis of the concentration of skin components (lipids, natural moisturizing factor molecules, water) and the penetration depth of cosmetic/medical formulations in the human stratum corneum (SC) in vivo. In recent years, it was shown that confocal Raman microspectroscopy can also be used for non-invasive in vivo depth-dependent determination of the physiological parameters of the SC, such as lamellar and lateral organization of intercellular lipids, folding properties of keratin, water mobility and hydrogen bonding states. The results showed that the strongest skin barrier function, which is primarily manifested by the orthorhombic organization of intercellular lipids, is provided at ≈20–40% SC depth, which is related to the maximal bonding state of water with surrounding components in the SC. The secondary and tertiary structures of keratin determine water binding in the SC, which is depth-dependent. This paper shows the technical possibility and advantage of confocal Raman microspectroscopy in non-invasive investigation of the skin and summarizes recent results on in vivo investigation of the human SC.

Assessment of the “Skin Reservoir” of Urea by Confocal Raman Microspectroscopy and Reverse Iontophoresis in vivo

2007 ◽  
Vol 24 (10) ◽  
pp. 1897-1901 ◽  
Author(s):  
Valentine Wascotte ◽  
Peter Caspers ◽  
Johanna de Sterke ◽  
Michel Jadoul ◽  
Richard H. Guy ◽  
...  
Keyword(s):  
Raman Microspectroscopy ◽  
Reverse Iontophoresis ◽  
Skin Reservoir ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

Confocal Raman Microspectroscopy for Evaluating the Stratum Corneum Removal by 3 Standard Methods

2011 ◽  
Vol 24 (2) ◽  
pp. 103-112 ◽  
Author(s):  
M. Förster ◽  
M.A. Bolzinger ◽  
M.R. Rovere ◽  
O. Damour ◽  
G. Montagnac ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Raman Microspectroscopy ◽  
Standard Methods ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman

scholarly journals In Vivo Confocal Raman Microspectroscopy of the Skin: Noninvasive Determination of Molecular Concentration Profiles

2001 ◽  
Vol 116 (3) ◽  
pp. 434-442 ◽  
Author(s):  
Peter J. Caspers ◽  
Hajo A. Bruining ◽  
Gerwin J. Puppels ◽  
Gerald W. Lucassen ◽  
Elizabeth A. Carter
Keyword(s):  
Raman Microspectroscopy ◽  
Concentration Profiles ◽  
Molecular Concentration ◽  
Confocal Raman Microspectroscopy ◽  
Confocal Raman
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