Novel design for suspension array detection system

2005 ◽  
Author(s):  
Guoxiong Xu ◽  
Yan Shi ◽  
Xuxiang Ni ◽  
Zukang Lu
Keyword(s):  
Detection System ◽  
Suspension Array ◽  
Array Detection ◽  
Novel Design

Abstract 4336: Interrogating the Human Myocardial Interstitium during Myocardial Arrest and Reperfusion: Dynamic Changes in Cytokines and Protease Activity

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Robert E Stroud ◽  
Christine N Koval ◽  
Isabelle Gengler ◽  
Anne M Deschamps ◽  
John S Ikonomidis ◽  
...  
Keyword(s):  
Detection System ◽  
Ischemia Reperfusion ◽  
Dynamic Assessment ◽  
High Sensitivity ◽  
Fluorescent Detection ◽  
Suspension Array ◽  
Cytokine Analysis ◽  
And Function ◽  
Inflammatory Molecules ◽  
Pulmonary Bypass

Background. Cytokines, such as the interleukins (IL1β, IL2, IL6) and tumor necrosis factor (TNF) can modulate myocardial structure and function with ischemia/reperfusion (I/R) but dynamic assessment of these biological molecules within the human myocardial interstitium with I/R has not been performed, and the inter-relationship to matrix metalloproteinases activity (MMPact) remains unexplored. Accordingly, a fluorogenic microdialysis method was used to simultaneously measure myocardial interstitial cytokine levels and MMPact in patients during and following I/R. Methods . MMPact was measured in patients (n=13) undergoing cardio-pulmonary bypass (CPB) at baseline, during myocardial arrest and CPB (on-CPB), and immediately following reperfusion and separation from CPB (post-CPB) by a validated in-line microdialysis fluorescent detection system. Myocardial interstitial fluid was subjected to cytokine analysis by high sensitivity multiplex suspension array. Results . Interstitial MMPact increased by over 30% post-CPB and was accompanied by a specific change in cytokine profiles (Figure ). The classical pro-inflammatory molecules such as TNF and IL6 were either not detectable or unchanged, whereas IL1β and IL2 which can be proinflammatory, were increased. Conclusions. These unique results demonstrated that a dynamic cytokine signature occurs within the human myocardial interstitium following I/R and is temporally related to heightened MMP activity. Direct interrogation of the human myocardial interstitium may provide a unique insight into critical signaling pathways which may evoke adverse structural and functional events following I/R.

Research on a New Detection Technique of FBG Using OTDR

2011 ◽  
Vol 317-319 ◽  
pp. 2346-2350
Author(s):  
Xiu Mei Jin ◽  
Yu Mei Lv ◽  
Li Feng Du
Keyword(s):  
Time Domain ◽  
Detection System ◽  
Time Domain Reflectometry ◽  
Resonance Peak ◽  
Optical Time Domain Reflectometry ◽  
Array Detection ◽  
A New Technique ◽  
Optical Time ◽  
Reflected Power ◽  
Time Division

A new technique of using Optical Time Domain Reflectometry (OTDR) to detect the reflected power of FBG sensing array was researched systematically. The theoretical model between the reflected power detected by OTDR and the reflected wavelength of FBG was established by analyzing, and consequently the selection rule of FBG wavelength in OTDR detection system was proposed. Moreover, experiments about multi-combination of FBGs with high reflectivity were carried out. The cause of dummy peak and resonance peak in OTDR test curves were analyzed, and meanwhile the selection basis of FBG reflectivity was also given. Based on time division multiplexing theory, detecting low-reflectivity FBG by OTDR can increase the FBG multiplexing number greatly, which has wide prospect to be applied in FBG array detection.

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