Nanopatterned structures for biomolecular analysis toward genomic and proteomic applications

2005 ◽  
Author(s):  
Chia-Fu Chou ◽  
Jian Gu ◽  
Qihuo Wei ◽  
Yingjie Liu ◽  
Ravi Gupta ◽  
...  
Keyword(s):  
Biomolecular Analysis

A Microfluidic Device for Studying Mass Transfer Effects in Biomolecular Analysis

2002 ◽  
Author(s):  
Min Yue ◽  
Katherine Dunphy ◽  
Jerry Jenkins ◽  
Christopher Dames ◽  
Guanghua Wu ◽  
...  
Keyword(s):  
Mass Transfer ◽  
Microfluidic Device ◽  
Transfer Effects ◽  
Biomolecular Analysis

A lazy feature selection method for multi-label classification

2021 ◽  
Vol 25 (1) ◽  
pp. 21-34
Author(s):  
Rafael B. Pereira ◽  
Alexandre Plastino ◽  
Bianca Zadrozny ◽  
Luiz H.C. Merschmann
Keyword(s):  
Feature Selection ◽  
Text Categorization ◽  
Feature Selection Method ◽  
Selection Method ◽  
Video Classification ◽  
Classification Problems ◽  
Class Label ◽  
New Feature ◽  
Feature Selection Techniques ◽  
Biomolecular Analysis

In many important application domains, such as text categorization, biomolecular analysis, scene or video classification and medical diagnosis, instances are naturally associated with more than one class label, giving rise to multi-label classification problems. This has led, in recent years, to a substantial amount of research in multi-label classification. More specifically, feature selection methods have been developed to allow the identification of relevant and informative features for multi-label classification. This work presents a new feature selection method based on the lazy feature selection paradigm and specific for the multi-label context. Experimental results show that the proposed technique is competitive when compared to multi-label feature selection techniques currently used in the literature, and is clearly more scalable, in a scenario where there is an increasing amount of data.

scholarly journals Nerve Growth Factor (NGF) modulates in vitro induced myofibroblasts by highlighting a differential protein signature

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Graziana Esposito ◽  
Bijorn Omar Balzamino ◽  
Egidio Stigliano ◽  
Filippo Biamonte ◽  
Andrea Urbani ◽  
...  
Keyword(s):  
Nuclear Translocation ◽  
Cell Signalling ◽  
Specific Protein ◽  
Conditioned Media ◽  
Cell Extracts ◽  
Dose Dependent Decrease ◽  
Significant Expression ◽  
Biomolecular Analysis ◽  
Protein Signature

AbstractWe previously described the profibrogenic effect of NGF on conjunctival Fibroblasts (FBs) and its ability to trigger apoptosis in TGFβ1-induced myofibroblasts (myoFBs). Herein, cell apoptosis/signalling, cytokines’ signature in conditioned media and inflammatory as well as angiogenic pathway were investigated. Experimental myoFBs were exposed to NGF (0.1–100 ng/mL), at defined time-point for confocal and biomolecular analysis. Cells were analysed for apoptotic and cell signalling activation in cell extracts and for some inflammatory and proinflammatory/angiogenic factors’ activations. NGF triggered cJun overexpression and phospho-p65-NFkB nuclear translocation. A decreased Bcl2:Bax ratio and a significant expression of smad7 were confirmed in early AnnexinV-positive myoFBs. A specific protein signature characterised the conditioned media: a dose dependent decrease occurred for IL8, IL6 while a selective increase was observed for VEGF and cyr61 (protein/mRNA). TIMP1 levels were unaffected. Herein, NGF modulation of smad7, the specific IL8 and IL6 as well as VEGF and cyr61 modulation deserve more attention as opening to alternative approaches to counteract fibrosis.

Nano-structured optical fiber bundles for remote SPR detection: a first step toward in vivo biomolecular analysis

2017 ◽  
Author(s):  
Karim Vindas ◽  
Elodie Engel ◽  
Patrick Garrigue ◽  
Thierry Livache ◽  
Stéphane Arbault ◽  
...  
Keyword(s):  
Optical Fiber ◽  
Fiber Bundles ◽  
Biomolecular Analysis

scholarly journals Label-free, multiplexed biomolecular analysis using arrays of silicon photonic microring resonators

2011 ◽  
Vol 25 ◽  
pp. 63-66 ◽  
Author(s):  
Adam L. Washburn ◽  
Matthew S. Luchansky ◽  
Melinda S. McClellan ◽  
Ryan C. Bailey
Keyword(s):  
Microring Resonators ◽  
Label Free ◽  
Silicon Photonic ◽  
Silicon Photonic Microring Resonators ◽  
Biomolecular Analysis

A novel miniature confocal microscope/Raman spectrometer system for biomolecular analysis on future Mars missions after Antarctic trials

2000 ◽  
Vol 31 (7) ◽  
pp. 633-635 ◽  
Author(s):  
David L. Dickensheets ◽  
David D. Wynn-Williams ◽  
Howell G. M. Edwards ◽  
Christian Schoen ◽  
Chelle Crowder ◽  
...  
Keyword(s):  
Confocal Microscope ◽  
Raman Spectrometer ◽  
Spectrometer System ◽  
Biomolecular Analysis ◽  
Mars Missions

High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry with Increased Throughput for Biomolecular Analysis

2014 ◽  
Vol 86 (18) ◽  
pp. 9020-9028 ◽  
Author(s):  
Konstantin O. Nagornov ◽  
Mikhail V. Gorshkov ◽  
Anton N. Kozhinov ◽  
Yury O. Tsybin
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
High Resolution ◽  
Cyclotron Resonance ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron ◽  
Biomolecular Analysis

scholarly journals Profile of patients with gastrointestinal stromal tumors (GIST)

2015 ◽  
Vol 28 (2) ◽  
pp. 124-127 ◽  
Author(s):  
Eduardo Marcucci PRACUCHO ◽  
Luiz Roberto LOPES ◽  
Renato Morato ZANATTO ◽  
Karla Thaisa TOMAL ◽  
Celso Roberto PASSERI ◽  
...  
Keyword(s):  
Tyrosine Kinases ◽  
Public Hospital ◽  
Patient Survival ◽  
Residual Disease ◽  
Imaging Finding ◽  
R0 Resection ◽  
Free Survival ◽  
Stromal Tumors ◽  
R1 Resection ◽  
Biomolecular Analysis

BACKGROUND: There is an improvement on the GIST treatment in last decade due to biomolecular research and adjuvant therapy with tyrosine kinases inibitors. However, both modalities of treatment rarely are available in Brazilian public hospital. AIM: Evaluate GIST patients profile in public oncologic hospital. METHODS: A retrospective study was made on patients with GIST diagnosed and treated between 2001 and 2013. RESULTS: Sixty-nine patients were included, mean age 59 years with slight predominance in females (51%). The main symptom was abdominal pain associated with incidental imaging finding. The occurrence of other associated neoplasm was in 28.8% of cases. The positivity of CD117 was 97.1%. The most frequent location was the stomach in 55.1% of cases. The R0 resection was possible in 63.8% and the recurrence rate was 20.3 %, with liver and peritoneum the main affected sites. Overall survival in the whole sample was 71%. Free survival rate of disease was 64%. The use of imatinib was limited to patients with residual disease (unresectable disease, R2 and R1 resection), metastatic disease or recurrence. CONCLUSION: In order to improve GIST treatment is necessary to add the biomolecular analysis to risk stratification. However, for this to occur, incentive in biomolecular research is required, to increase the possibility of patient survival.

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