High-sensitivity photon-counting imaging detector

2005 ◽  
Author(s):  
Lichen Fu ◽  
Ye Li ◽  
Qingduo Duanmu ◽  
Guozheng Wang ◽  
Kui Wu ◽  
...  
2021 ◽  
Vol 4 (9) ◽  
pp. 681-688
Author(s):  
Sarah Deumel ◽  
Albert van Breemen ◽  
Gerwin Gelinck ◽  
Bart Peeters ◽  
Joris Maas ◽  
...  

AbstractTo realize the potential of artificial intelligence in medical imaging, improvements in imaging capabilities are required, as well as advances in computing power and algorithms. Hybrid inorganic–organic metal halide perovskites, such as methylammonium lead triiodide (MAPbI3), offer strong X-ray absorption, high carrier mobilities (µ) and long carrier lifetimes (τ), and they are promising materials for use in X-ray imaging. However, their incorporation into pixelated sensing arrays remains challenging. Here we show that X-ray flat-panel detector arrays based on microcrystalline MAPbI3 can be created using a two-step manufacturing process. Our approach is based on the mechanical soft sintering of a freestanding absorber layer and the subsequent integration of this layer on a pixelated backplane. Freestanding microcrystalline MAPbI3 wafers exhibit a sensitivity of 9,300 µC Gyair–1 cm–2 with a μτ product of 4 × 10–4 cm2 V–1, and the resulting X-ray imaging detector, which has 508 pixels per inch, combines a high spatial resolution of 6 line pairs per millimetre with a low detection limit of 0.22 nGyair per frame.


1989 ◽  
Vol 131 ◽  
pp. 182-182
Author(s):  
Luciana Bianchi ◽  
Michael Greving ◽  
J. Barnstedt ◽  
Chr. Diesch

We present newly determined expansion velocities for a number of Planetary Nebulae (PNe) which have been observed with the ESO 1.4m CAT and the Coude' Echelle Spectrograph (CES), operated at a r.p. of 105, corresponding to a resolution of about 3km/s at Hα. Two detector systems have been used: the standard ESO Reticon and a two-dimensional photon-counting imaging detector developed at the A.I.T. (AIT-MCP-Camera).


2013 ◽  
Vol 336-338 ◽  
pp. 373-378
Author(s):  
Cui Lan Zhao ◽  
Yong Ping Li ◽  
Li Hong Chen ◽  
Chao Yuan ◽  
Yu Jin Qi

Cerium activated lanthanum bromide (LaBr3:Ce3+) scintillator crystal has shown very promising characteristics for high-resolution and high-sensitivity gamma ray imaging and spectrometric applications [1,2,. In this paper, we present some preliminary results of a compact gamma camera based on LaBr3:Ce3+ crystal. The detector module consists of a continuous LaBr3:Ce3+ crystal with a sensitive area of 50x50 mm2 and 5mm thickness coupling to a Hamamatsu H8500 position-sensitive photomultiplier tube (PSPMT). A compact multiplexed readout based on symmetric charge division circuit (SCD) was developed to reduce the 64 anode signal to 16 readout channels, and a resistive division network to reduce the readout channels from 16 to 4. The performance of the imaging detector module was tested using a 57Co source. The preliminary results showed that this detector module can achieve an effective field-of-view (FOV) of ~39x39 mm2 with a good intrinsic spatial resolution around 1.5mm and energy resolution of 9.2% at 122 keV.


Author(s):  
Donald E. Casperson ◽  
William C. Priedhorsky ◽  
Miles H. Baron ◽  
Cheng Ho

1993 ◽  
Vol 41 (11) ◽  
pp. 1591-1597 ◽  
Author(s):  
P Lorimier ◽  
L Lamarcq ◽  
F Labat-Moleur ◽  
C Guillermet ◽  
R Bethier ◽  
...  

The breakthrough of chemiluminescence in the field of solution immunoassays and transfer membranes prompted us to explore whether a light-based detection system could provide a gain in sensitivity over chromogenic and FITC markers for nucleic acid and protein detection on histological preparations. A Hamamatsu device and an enhanced chemiluminescence (ECL) luminol substrate of the peroxidase were used to detect epithelial and endothelial components by immunohistochemistry (IHC) and for in situ hybridization (ISH) of papilloma virus DNA. The accuracy of the signal was compared to that obtained with DAB-peroxidase, silver-enhanced DAB-peroxidase, NBT-BCIP-alkaline phosphatase, and FITC. Our results demonstrated the feasibility and high sensitivity of luminescence detection for histological preparations. In part due to the ultrasensitive videocamera and photon-counting imaging, interpretable and reproducible results were obtained within counting times shorter than 5 min, and with dilutions of the primary antibodies 100- to 10,000-fold greater than those used for chromogenic and FITC reactions. As for ISH, with identical concentrations of the HPV 18 DNA probe on HeLa cells, labeling was apparent by luminescence but undetectable with the chromogen. The morphological resolution allowed a discriminatory analysis of the signal. Therefore, at the light microscopic level, enhanced chemiluminescence offers an appealing alternative to FITC and chromogenic markers for detection and quantification of low-concentration molecules.


2021 ◽  
Vol 28 (2) ◽  
pp. 439-447
Author(s):  
Yasukazu Nakaye ◽  
Takuto Sakumura ◽  
Yasutaka Sakuma ◽  
Satoshi Mikusu ◽  
Arkadiusz Dawiec ◽  
...  

Hybrid photon counting (HPC) detectors are widely used at both synchrotron facilities and in-house laboratories. The features of HPC detectors, such as no readout noise, high dynamic range, high frame rate, excellent point spread function, no blurring etc. along with fast data acquisition, provide a high-performance detector with a low detection limit and high sensitivity. Several HPC detector systems have been developed around the world. A number of them are commercially available and used in academia and industry. One of the important features of an HPC detector is a fast readout speed. Most HPC detectors can easily achieve over 1000 frames s−1, one or two orders of magnitude faster than conventional CCD detectors. Nevertheless, advanced scientific challenges require ever faster detectors in order to study dynamical phenomena in matter. The XSPA-500k detector can achieve 56 kframes s−1 continuously, without dead-time between frames. Using `burst mode', a special mode of the UFXC32k ASIC, the frame rate reaches 1 000 000 frames s−1. XSPA-500k was fully evaluated at the Metrology beamline at Synchrotron SOLEIL (France) and its readout speed was confirmed by tracking the synchrotron bunch time structure. The uniformity of response, modulation transfer function, linearity, energy resolution and other performance metrics were also verified either with fluorescence X-rays illuminating the full area of the detector or with the direct beam.


2019 ◽  
Vol 12 (6) ◽  
pp. 1303-1310
Author(s):  
何玲平 HE Ling-ping ◽  
岳巾英 YUE Jin-ying ◽  
张宏吉 ZHANG Hong-ji ◽  
陈 波 CHEN Bo

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