Comparative analysis of the self-association of ethidium mono- and bis-intercalators in aqueous solution using 1H NMR spectroscopy

2004 ◽  
Author(s):  
Maxim P. Evstigneev ◽  
Adrian A. Hernandez Santiago ◽  
Olga V. Rogova ◽  
Alexei N. Veselkov
Keyword(s):  
Aqueous Solution ◽  
Comparative Analysis ◽  
Nmr Spectroscopy ◽  
The Self ◽  
H Nmr ◽  
Self Association

The self-association of the drug acemetacin and its interactions and stabilization with β-cyclodextrin in aqueous solution as inferred from NMR spectroscopy and HPLC studies

2002 ◽  
Vol 337 (15) ◽  
pp. 1387-1395 ◽  
Author(s):  
Dimitris Zouvelekis ◽  
Konstantina Yannakopoulou ◽  
Irene M Mavridis ◽  
Ekaterini Antoniadou-Vyza
Keyword(s):  
Aqueous Solution ◽  
Nmr Spectroscopy ◽  
The Self ◽  
Self Association

The self-association of naturally occurring purine nucleoside 5′-monophosphates in aqueous solution

1979 ◽  
Vol 57 (15) ◽  
pp. 1986-1994 ◽  
Author(s):  
Klaus J. Neurohr ◽  
Henry H. Mantsch
Keyword(s):  
Aqueous Solution ◽  
Hydrophobic Interactions ◽  
Equilibrium Constants ◽  
The Self ◽  
Purine Nucleoside ◽  
Base Stacking ◽  
H Nmr ◽  
Induced Dipole ◽  
Stacking Pattern ◽  
Self Association

The parameters characterizing the base-stacking self-association of adenosine, inosine, and guanosine 5′-monophosphate have been obtained from 1H nmr dilution studies. The thermodynamic parameters for the formation of adenosine 5′-monophosphate stacks are ΔH0 = −14.5 kJ mol−1 and ΔS0 = −42.3 J K−1 mol−1, with an apparent equilibrium constant of Kc = 1.92 M−1 at 30 °C. The corresponding equilibrium constants for the self-association of inosine and guanosine 5′-monophosphate are 1.36 M−1 and 1.29 M−1, respectively. The negative enthalpy and entropy changes cannot be explained by the concept of classical hydrophobic interactions; however, they strongly support the conclusion that dipole induced dipole forces play a major role for base-stacking in aqueous solution. The sequence of the equilibrium constants for the purine nucleoside 5′-monophosphates can be well explained by the concept of mutual polarization. The stacking geometries for adenosine and inosine 5′-monophosphate are presented as obtained from fitting the experimental shift data to refined isoshielding contours. It is concluded that the stacking pattern is not restricted to a unique geometry.

scholarly journals Distinctive features of the self-association of deoxyhexanucleotide 5'-d(GpCpApTpGpC) and its complexation with anthracycline antibiotic daunomycin in aqueous solution

2004 ◽  
Vol 20 (6) ◽  
pp. 479-492
Author(s):  
A. N. Veselkov ◽  
R. J. Eaton ◽  
V. I. Pahomov ◽  
O. V. Rogova ◽  
V. S. Volynkin ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
The Self ◽  
Anthracycline Antibiotic ◽  
Distinctive Features ◽  
Self Association

A vibrational spectroscopic study of the self-association of 5?-GMP in aqueous solution

Biopolymers ◽  
1991 ◽  
Vol 31 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Pierre Audet ◽  
Christine Simard ◽  
Rodrigue Savoie
Keyword(s):  
Aqueous Solution ◽  
Spectroscopic Study ◽  
The Self ◽  
Self Association

Deep insights into the hydrolysis of N,N -dialkylaminoethyl methacrylates in aqueous solution with 1 H NMR spectroscopy

2018 ◽  
Vol 56 (12) ◽  
pp. 914-923
Author(s):  
Pengfei Zheng ◽  
Xin Su ◽  
Chenhong Fei ◽  
Xiaohuo Shi ◽  
Hongyao Yin ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Nmr Spectroscopy ◽  
H Nmr ◽  
Hydrolysis Of
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