Comparative analysis of the self-association of ethidium mono- and bis-intercalators in aqueous solution using 1H NMR spectroscopy

2004 ◽  
Author(s):  
Maxim P. Evstigneev ◽  
Adrian A. Hernandez Santiago ◽  
Olga V. Rogova ◽  
Alexei N. Veselkov
2002 ◽  
Vol 337 (15) ◽  
pp. 1387-1395 ◽  
Author(s):  
Dimitris Zouvelekis ◽  
Konstantina Yannakopoulou ◽  
Irene M Mavridis ◽  
Ekaterini Antoniadou-Vyza

1979 ◽  
Vol 57 (15) ◽  
pp. 1986-1994 ◽  
Author(s):  
Klaus J. Neurohr ◽  
Henry H. Mantsch

The parameters characterizing the base-stacking self-association of adenosine, inosine, and guanosine 5′-monophosphate have been obtained from 1H nmr dilution studies. The thermodynamic parameters for the formation of adenosine 5′-monophosphate stacks are ΔH0 = −14.5 kJ mol−1 and ΔS0 = −42.3 J K−1 mol−1, with an apparent equilibrium constant of Kc = 1.92 M−1 at 30 °C. The corresponding equilibrium constants for the self-association of inosine and guanosine 5′-monophosphate are 1.36 M−1 and 1.29 M−1, respectively. The negative enthalpy and entropy changes cannot be explained by the concept of classical hydrophobic interactions; however, they strongly support the conclusion that dipole induced dipole forces play a major role for base-stacking in aqueous solution. The sequence of the equilibrium constants for the purine nucleoside 5′-monophosphates can be well explained by the concept of mutual polarization. The stacking geometries for adenosine and inosine 5′-monophosphate are presented as obtained from fitting the experimental shift data to refined isoshielding contours. It is concluded that the stacking pattern is not restricted to a unique geometry.


2004 ◽  
Vol 20 (6) ◽  
pp. 479-492
Author(s):  
A. N. Veselkov ◽  
R. J. Eaton ◽  
V. I. Pahomov ◽  
O. V. Rogova ◽  
V. S. Volynkin ◽  
...  

Biopolymers ◽  
1991 ◽  
Vol 31 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Pierre Audet ◽  
Christine Simard ◽  
Rodrigue Savoie

2018 ◽  
Vol 56 (12) ◽  
pp. 914-923
Author(s):  
Pengfei Zheng ◽  
Xin Su ◽  
Chenhong Fei ◽  
Xiaohuo Shi ◽  
Hongyao Yin ◽  
...  

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