Characterization of the hydration state of pharmaceuticals by variable-temperature diffuse-reflectance infrared spectroscopy

1992 ◽  
Author(s):  
Frank M. Wasacz ◽  
Scott W. Strand ◽  
David E. Bugay ◽  
Kenneth R. Morris
Keyword(s):  
Infrared Spectroscopy ◽  
Diffuse Reflectance ◽  
Variable Temperature ◽  
Diffuse Reflectance Infrared Spectroscopy ◽  
Hydration State ◽  
Diffuse Reflectance Infrared

Requirements for Thermal Analysis by Variable-Temperature Diffuse Reflectance Infrared Spectroscopy

1992 ◽  
Vol 46 (10) ◽  
pp. 1508-1513 ◽  
Author(s):  
Robert L. White
Keyword(s):  
Infrared Spectroscopy ◽  
Calcium Oxalate ◽  
Diffuse Reflectance ◽  
Variable Temperature ◽  
Calcium Oxalate Monohydrate ◽  
Quantitative Information ◽  
Center Frequency ◽  
Effect Of Temperature ◽  
Diffuse Reflectance Infrared Spectroscopy ◽  
Diffuse Reflectance Infrared

The effect of temperature on diffuse reflectance infrared spectroscopy measurements is discussed. Instrumental parameters that determine the accuracy of variable-temperature diffuse reflectance Fourier transform infrared spectroscopy (VT-DRIFTS) measurements are identified, and methods for removing baseline artifacts resulting from fluctuations in these parameters are given. Procedures for extracting structure-specific quantitative information from DRIFTS spectra acquired at different temperatures are outlined. The use of VT-DRIFTS to generate vibration-specific absorbance band intensity and center frequency temperature profiles for calcium oxalate monohydrate is described, and correlations between these profiles and the known thermal behavior of calcium oxalate monohydrate are given.

Figures of Merit for a Diffuse Reflectance Accessory Using an On-Axis Ellipsoidal Collecting Mirror

1988 ◽  
Vol 42 (3) ◽  
pp. 428-433 ◽  
Author(s):  
E. H. Korte
Keyword(s):  
Infrared Spectroscopy ◽  
Noise Level ◽  
Diffuse Reflectance ◽  
Field Of View ◽  
Figures Of Merit ◽  
Size Dependent ◽  
Diffuse Reflectance Infrared Spectroscopy ◽  
Diffuse Reflectance Infrared

The attainable efficiency of an accessory for diffuse reflectance infrared spectroscopy where both the irradiation and detection optics are located on the same side of the sample is analyzed, the size-dependent noise level of the detector being taken into account. The resulting figures of merit are found to reach up to more than 0.3, when standard detectors of 60° field-of-view are considered.

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